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Lecture 29
Oxidative Phosporylation
Question | Answer |
---|---|
Why are the words “oxidative” and “phosphorylation” used to describe this process? | Oxidative refers to NADH donating its electron and phosphorylation refers to ADP being phosphorylated |
What donates electrons to begin electron transport? | NADH |
Where does glycolysis take place in the cell | In the cytosol |
Where is pyruvate converted to acetyl CoA? | in the mitochondrial matrix |
What complex does cyanide affect? | Cyanide binds to Complex lV and inhibits electron flow. |
What was the substrate and product of the Kreb’s cycle generates FADH2? | Succinate |
What donates electrons to complex lll? | Q |
What does complex lll donate electrons to? | cytochrome c |
What donates electrons to complex lV? | cytochrome c |
How many protons are pumped through complex lV to reduce O2? | 4 protons |
What are the three major sources of FAD? | B-oxidation of fatty acids, glycerol-3-p, succinate dehydrogenase |
How many ATPs are produced from 1 NADH? | 2.5 |
What part of the ATP synthase binds protons? | Protons bind aspartate in which cause the c-subunit of Fo to rotate |
What happens to F1 when electrons flow through the Fo pore ? | The a and B subunits go through a conformational change |
What is the role of the gamma subunit in ATP synthesis? | When protons enter Fo the c-subunit and the gamma subunit rotate. The gamma subunit passes in between the a and B subunits of F1 and causes the conformational change. |
How many ATP are synthesized from one rotation of ATP synthase? | 3 ATP |
How many ATP and ADP are bound to ATP synthase at one time? | 1 ATP and 1 ADP (the lase set of a/B subunits is empty) |