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G-protein 2nd messen
GP second messengers
| Question | Answer |
|---|---|
| List of adrenergic receptors: | α1, α2, ß1, ß2, ß3 |
| List of cholinergic receptors: | M1, M2, M3 |
| List of Dopamine receptors | D1, D2 |
| List of Histamine receptors | H1, H2 |
| List of Vasopressin receptors: | V1, V2 |
| Which receptors have q-protein class? | H1, α1, V1, M1, M3 |
| Which receptors have i-protein class? | M2, α2, D2 |
| Which receptors have s-protein class? | ß1, ß2, ß3, D1, H2, V2 |
| What are the major functions of α-1 adrenergic receptors? | ↑ vascular smooth muscle contraction, ↑ pupillary dilator muscle contraction (mydriasis), ↑ intestinal and bladder sphincter muscle contraction |
| ↑ vascular smooth muscle contraction | α1 |
| What are the major functions of α-2 adrenergic receptors? | ↓ sympathetic (adrenergic) outflow, ↓ insulin release, ↓ lipolysis, ↓ aqueous humor production and ↑platelet aggregation. |
| Which adrenergic receptor causes a ↓ in sympathetic outflow? | α-2 |
| What are the major functions of ß-1 receptors? | ↑ HR, ↑ contractility, ↑ renin release and lipolysis |
| What are the major functions of ß-2 receptors? | VASODILATION and BRONCHODILATION, ↑: Lipolysis, insulin release, glycogenolysis, aqueous humor production, cellular K+ uptake ↓: in uterine tone (tocolysis) |
| What are the major functions of ß-3 receptors? | ↑↑↑ in lipolysis, thermogenesis in skeletal muscle, and bladder relaxation |
| Which ß-receptors is associated with a ↑ in bladder relaxation? | ß-3 |
| Mediates higher cognitive functions, stimulates enteric NS: | M1 |
| What are the major functions of M1 receptors? | Mediation of higher cognitive functions and stimulation of enteric nervous system |
| Which Gp-second messenger is associated with ↓ in heart rate and contractility of the atria? | M2 |
| What are the major functions of M2 receptors? | ↓ HR and contractility of the atria |
| What are some associated functions of M3 receptor agonism? | ↑ Exocrine gland secretions (lacrimal, sweat, salivary, and gastric acid), bladder contraction, bronchoconstriction, miosis, ciliary muscle contraction (accommodation), insulin release, endothelium-mediated vasodilation. |
| What are the major functions of D1 receptors? | Relaxes renal vascular smooth muscle, activates direct pathway of striatum |
| What are the major functions of D2 receptors? | Modulates transmitter release, especially in brain, inhibits indirect pathway of striatum. |
| _____ activates _______ pathway of striatum | D1; direct |
| _____ inhibits ________ pathway of striatum | D2; indirect |
| What are the major functions of H1 receptors? | ↑ nasal and bronchial mucus production, ↑ vascular permeability and vasodilation, bronchoconstriction, pruritus, and pain. |
| What are the major functions of H2 receptors? | ↑ gastric acid secretion |
| What are the main functions of V1 receptors? | ↑ vascular smooth muscle contraction |
| What are the main functions of V2 receptors? | ↑ water permeability and reabsorption via upregulating aquaporin-2 in collecting tubules of the kidney, and ↑ release of vWF. |
| Which two G-protein second messengers ↑ vascular smooth muscle contractility? | α1 and V1 |
Created by:
rakomi
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