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DRUG ICARDS

Salbutamol

QuestionAnswer
Mechanism of action Salbutamol is a bronchodilator. It is an agonist of the beta 2 receptors
Indications (4) -Bronchospasm secondary to asthma or COPD -Prominent bronchospasm secondary to airway burns, smoke inhalation or chest infection. -Release syndrome following crush injury. -suspected hyperkalaemia with ECG changes
Contraindications Known severe allergy
Cautions None
Dosage MDI: one puff in spacer per six breaths. repeat 6 times -Nebulised for bronchospasm: 5mg for adults and children, repeated as required -nebulised for release syndrome or suspected hyperkalaemia. 5mg and repeat as needed
Adverse effects -tremor -tachycardia
Usual onset of effects 1-2 hours
Usual preparation -metered dose inhaler delivering 100mcg doses per puff -ampoule containing 5mg in 2.5ml -ampoule containing 2.5mg in 2.5ml
Pharmacokinetics -only a small amount absorbed -is metabolised in the liver and excreted in the urine -no significant effects from liver or kidney impairment on acute administration
Common interactions less effective in the presence of a beta-blocker, with the reduction in effect being most pronounced with a non- selective beta blocker such as propranolol
additional information does not have a significant effect in the role of treatment of bronchospasm as a result of smoke, toxic gas inhalation.
Created by: nicolaprice01
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