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DRUG ICARDS

Midazolam

QuestionAnswer
Midazolam Mechanism of action -midazolam is a benzodiazepine -Enhances the activity of gamma-aminobutyric acid (GABA) receptors within the central nervous system, resulting in anticonvulsant activity, sedation, amnesia, anxiolysis, and muscle relaxation.
Midazolam paramedic scope -IM and IV for seizures -IM acute behavioral disturbances
Indication (2) Paramedic -Generalised seizure that continue for more than five minutes, or seizures are recurrent. -Acute behavioural disturbance causing a mild to moderate risk to safety and droperidol is unavailable or ineffective.
Contraindications (2) -Known severe allergy -Age less than 12 years (analgesia only if out of scope)
Cautions (5) -Altered level of consciousness. -Respiratory depression. -Signs of shock. -Concurrent administration of opiates or ketamine. prolongs effects. -Age greater or equal to 75 years, particularly if frail.
Administration IV -Dilute 2ml from 15mg/3ml to a total of 10ml. contains 1mg/ml
Administration IM Undiluted
Common adverse effects -Sedation -Respiratory depression -Hypotension -Amnesia
Usual onset of effects - IV 2-3 mins -IM 3-5 mins
Usual preparation Ampoule containing 15mg in 3 ml
Pharmacokinetics -predominantly metabolised in the liver -no significant effects from liver impairment on acute administration.
Created by: nicolaprice01
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