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DRUG ICARDS

Tranexamic Acid

QuestionAnswer
Mechanism of action Tranexamic acid is an antifibrinolytic medicine. It blocks the conversion of plasminogen to plasmin, reducing fibrinolysis (breakdown of blood clots) and bleeding.
Indications (6) -Postpartum haemorrhage. -clinically significant bleeding from trauma -Non-traumatic bleeding and shock is severe -crush injury -cardiac arrest in secondary to trauma -Bleeding from tonsillectomy
Contraindications -Known severe allergy. -Trauma when Tranexamic acid will be administered more than three hours after the time of injury. This appears to increase mortality rates, the cause of which is not clear.
Dosage- clinically significant bleeding from trauma -2 g IV adult -See the paediatric drug dose tables for a child.
Usual onset of effect 30-60 minutes.
Usual duration of effect 8 hours.
Usual preparation Administer IV over 1-2 minutes. -10 ml ampoule containing 1 g -5 ml ampoule containing 500 mg.
Pharmacokinetics Tranexamic acid is predominantly excreted in the urine. Renal impairment does not alter the initial (loading) dose. Common interactions
Dosage- non traumatic severe shock -1 g IV adult
Dosage- Bleeding following tonsillectomy -500mg nebuilsed -1 g IV adult
Created by: nicolaprice01
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