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DRUG ICARDS

Tranexamic Acid

QuestionAnswer
Mechanism of action Tranexamic acid is an antifibrinolytic medicine. It blocks the conversion of plasminogen to plasmin, reducing fibrinolysis (breakdown of blood clots) and bleeding.
Indications (8) -Postpartum haemorrhage. -clinically significant bleeding or signs of hypovolaemia from trauma -Non-traumatic bleeding and shock is severe -cardiac arrest in secondary to trauma -Bleeding from tonsillectomy -Crush injury -Moderate to severe epistax
Contraindications -Known severe allergy. -Trauma when Tranexamic acid will be administered more than three hours after the time of injury. This appears to increase mortality rates, the cause of which is not clear.
Dosage- clinically significant bleeding from trauma -2 g IV adult -See the paediatric drug dose tables for a child.
Dosage-bleeding following tonsillectomy -500mg nebulised for an adult or child. Repeat once 30 min -1g IV for an adult
Dosage- non traumatic bleeding 1g IV for an adult -see paediatric drug tables for a child
Moderate to severe epistaxis ->12 years old 200mg (2ml) undiluted per bleeding nostril <5-11 years old 100mg per bleeding nostril -Seek clinical advice for age <5
Usual onset of effects 30-60 minutes
Duration of effects 8 hours
Usual preparation 1g in 10ml
Pharmacokinetics Tranexamic acid is predominantly excreted in the urine. Renal impairment does not alter the initial (loading) dose.
Created by: nicolaprice01
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