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Pernicious Anemia

blood disorder

QuestionAnswer
What is pernicious anemia Elderly effected mostly,Vit. B def. which is needed for DNA synthesis in maturing RBC. Autoimmune gastric mucosal atrophy. B12 is not absorbed.
Drugs that interfere with absoption of b12 ascorbic acid (vit. C), colchocine, neomycin, oral contraceptives
Signs and Symptoms low B12 levels,Pallor, fatique, palpitations, Angina, CHF, inflammation of tongue and mouth, sore mouth, anorexia, nausea, gi upset, jaundice, neurological issues like numbness in hands and feet, gait off and BB dysfunction
Diagnostic and Labs CBC, Blood smear, rbc, wbc, hematacrit, platelet count, gastric analysis and Schilling Test
What is Schillings Test? Small amount of radioactive B12 orally given and then 24 hr urine collecton to measure uptake of B12 to see if b12 is being absorbed.
Treatment of Pernicious Anemia IM B12 injections, quiet environment and reorietate pt if needed, safe environment, physical or occupational therapy may be needed.
Pt teaching advise to have monthy B12 injection for life, see doctor approx. every 6 months for hematologic sudies and GI evaluation, stool exam for accult blood, gastric cytology, and thyroid function test.
Created by: lshauntee
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