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Pharm ch 12-13

QuestionAnswer
cholinergic drugs parasympathomimetic
parasympathomimetic indirect MOA binds directly to muscarinic receptors to act like ACH and cause r/d
parasympathomimetic direct MOA binds to ACHe which prevents enzyme from breaking down ACH
Non obstructive urinary retention cholinergic drug bethanechol (Urocholine)
Alzehimers cholinergic drug donepezil (Aricept)
Mg Dx cholinergic drug edrophonium (Tensilon)
Mg Tx cholinergic drugs (3) physostigmine (Antilirium) pyridostigmine (Mestinan) neostigmine (Prostigmine)
cholinergic antagonist Parasympatholytic
Parasympatholytic MOA bind directly to the muscarinic receptor to block ACH from binding to cause f/f
IBS cholinergic antagonist dicyclomine (Bentyl)
OAB cholinergic antagonists (3) oxybutynin (Ditropan) tolteridine (Detrol) solifenacin (Vesicare)
Asthma/COPD cholinergic antagonists (2) ipratropium (Atrovent) tiatropium (Spriva)
Parkinsons cholinergic antagonist benztropine (Cogentin)
Anesthesia adjuvant cholinergic antagonist scopolamine (Transderm-Scop)
cholinergic antagonist for overdose atropine (Atropen)
bethanechol (Urocholine) use non-obstructive urinary retention
bethanechol (Urocholine) MOA contracts bladder
bethanechol (Urocholine) Admin Alerts monitor bp/hr one hour before and after
bethanechol (Urocholine) Treatment overdose atropine
bethanechol (Urocholine) drugs that inc effect diuretics, beta blockers
bethanechol (Urocholine) drugs that dec effect atropine, norepinephrine
bethanechol (Urocholine) adverse effects bradycardia, hypotension
bethanechol (Urocholine) contraindications obstructive urinary retention, BPH, Asthma, COPD, Bradycardia, Hypotension, colon problems
atropine (Atropen) use cholinergic overdose, cholinergic crisis, anesthesia adjunct
atropine (Atropen) MOA blocks the ACH from binding to the receptor
atropine (Atropen) Admin alert monitor bp and hr one hour before/after
atropine (Atropen) treatment overdose Antilirum
atropine (Atropen) drugs that inc effect epinephrine, norepinephrine, TCAs
atropine (Atropen) drugs that dec effect cholinergic drugs, antilirum
atropine (Atropen) Adverse effect tachycardia, inc bp, constipation, dry mouth
atropine (Atropen) contraindications urinary obstructive, myasthenia gravis, glaucoma
Adrenergic Drugs Sympathomimetic
alpha one receptors everywhere but the heart
alpha one drugs for Nasal decongestion (3) oxymetazoline (Afrin) phenylephrine (Neo-Synephrine) pseudoephedrine (Sudafed)
alpha one drugs for hypotension (2) dopamine (Dopastat, Intropin) epinephrine (Adrenalin)
alpha two receptors presynaptic terminals to dec release of NE
alpha two drug for ADHD clonidine (Catapres)
alpha two drug for hypertension methyldopa (Aldomet)
beta one receptors heart, and kidney
beta one drugs for MI, shock,HF (2) dobutamine (Dobutrex) dopamine (Dopastat, Intropin)
beta two receptors everywhere
beta two drug for asthma albuterol(Proventil, Ventolin)
beta two drug for premature labor terbutaline (Brethine, Terbulin)
beta two drug for Respiratory, Asthma, COPD phormaterol (Phoradil)
beta three receptors Adipose tissue, Urinary (bladder), Heart
beta three drug for OAB mirabegron (Myrbetriq)
phenylephrine (Neo-Synephrine) use vasoconstriction, reverse hypotension
phenylephrine (Neo-Synephrine) MOA Vasoconstriction in small vessels to leave more space
phenylephrine (Neo-Synephrine) Admin Alert extravasation
phenylephrine (Neo-Synephrine) Adverse effect hypertension, nasal irritation, rebound constriction, iv ( inc bp, dec hr)
phenylephrine (Neo-Synephrine) drugs that inc effect epinephrine, NE, TCAs, MAOis
phenylephrine (Neo-Synephrine) drugs that dec effect beta blockers, alpha blockers, cholinergic blockers
phenylephrine (Neo-Synephrine) treatment overdose Regitine
phenylephrine (Neo-Synephrine) black box warning IV is lethal
phenylephrine (Neo-Synephrine) contraindications cardiovascular disease, type 2 diabetes, glaucoma
Alpha blockers MOA Inhibiting NE from binding at Alpha Receptors
Alpha blockers uses HTN, BPH
ALpha blocker for both HTN and BPH doxazosin (Cardura)
ALpha blocker for HTN prazosin (Minipress)
ALpha blocker for BPH tamsulosin (Flomax)
Selective Beta blockers MOA Inhibiting NE from binding at Beta 1 Receptors
Selective Beta blockers use HTN
Non-Selective Beta blockers MOA Inhibiting NE from binding at Beta 1 & 2 Receptors
Non-Selective Beta blockers use HTN
Selective Beta blockers(2) atenolol (Tenormin) metoprolol (Lopressor, Toprol)
Non-Selective Beta blockers (5) propanolol (Inderal) labetolol (Trandate) timolol (Timoptic, Istalol) nadolol (Corgard) carvedilol (Coreg)
Adverse effects of Alpha blockers Orthostatic hypotension, first dose phenomenon
Adverse effects of Beta blockers bradycardia, hypotension
prazosin (Minipress) use hypertension
prazosin (Minipress) MOA keeps the NE from binding at the peripheral
prazosin (Minipress) Admin Alert short half life, builds a tolerance
prazosin (Minipress) Adverse effect orthostatic hypotension, 1st dose phenomenon, rebound tachycardia, nasal congestion
prazosin (Minipress) contraindications elderly, head trauma pts, tachycardia pt
prazosin (Minipress) drugs that inc effect ace inhibitors, beta/ alpha blockers, diuretics
prazosin (Minipress) drugs that dec effect adrenergic agonist, cholinergic blocker
prazosin (Minipress) treatment over dose saline, dopamine
prazosin (Minipress) herbal interactions saw palmetto dilation of BV to lower BP
Created by: Jlmasy
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