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Prelim 2 (LEC 12-13)

QuestionAnswer
Which of the following are extracellular fluids? (Blood plasma, interstitial fluid, intracellular fluid) Blood plasma, interstitial fluid
What is intracellular fluid? fluid in cells
What is interstitial fluid? fluid between cells
What is blood plasma? fluid in circulation (veins)
What makes up extracellular fluids? water, electrolytes, non-electrolytes (water and solutes)
Electrolytes ___ (dissociate/don't dissociate), while non-electrolytes _____ (dissociate/don't dissociate) dissociate, don't dissociate
Which ions generate action potentials? Na+ and K+
In an action potential ___ is OUTSIDE the cell, while ___ is INSIDE the cell. Na+, K+
What are extracellular fluids required for? maintaining cell structure, ensuring cell function, and acting as a vehicle for nutrients and chemicals
____ (hydrostatic/oncotic) pressure maintains tissues and organs in place. hydrostatic
Fluctuation of volume and solutes in ECF is ____ (dangerous/normal). dangerous
Ion loss/gain and water loss/gain are ____ (coupled, independent) independent
(Conformer or Regulator): cells are iso-osmotic with environment, no need for homeostasis conformer
(Conformer or Regulator): exist in unstable environments regulator
What are the 3 parameters regulated by regulators in ECF? volume of water, ionic concentration, osmotic pressure
Fish lose salt by ___ (diffusion/osmosis) and gain water by ____ (diffusion/osmosis). diffusion, osmosis
Fresh water fish ___ (uptake/secrete) Na+ and Cl-, in water, through their gills. uptake
What is the problem of living in fresh water? salt loss (diffusion) and water gain (osmosis)
Fresh water fish ins and outs: in: salt, water, ions out: water in dilute urine
What is the solution to living in fresh water? diluted urine, uptake of Na+ and Cl-
In fresh water fish, Cl- is coupled with ___ and Na+ is coupled with ____. carbonate, H+
What is the problem of living in sea water? water loss, salt gain
Sea water fish ___ (uptake/secrete) Na+ and Cl-, in water, through their gills. secrete
Fresh water fish ins and outs: in: water, ions out: salt in scanty urine
Low osmolarity environments (fresh water) present a ___ (dilution/concentration) risk? dilution
High osmolarity environments (salt water) present a ___ (dilution/concentration) risk? concentration
What is the solution to living in sea water? concentrated urine, secretion of Na+ and Cl-
What are the two kinds of dehydration? istonic, hypertonic
What is isotonic dehydration? loss of fluid, no change in concentration (volume drop)
Hypovolemia is an example of _____ (isotonic/hypertonic) dehydration. isotonic
What is hypertonic dehydration? high electrolyte levels
What is the other name for hypertonic dehydration? Hyponatremic (true) dehydration
___ is the method of water/salt intake. thirst
____ is the mechanism of water/salt output. extresion
Which part of the brain signals dehydration? hypothalamus
What are the steps of dehydration signaling? hypothalamic thirst center, thirst, water moistens mouth, throat, water absorbed from GI tract
What is another name for isotonic dehydration? hypovolemia
Intracellular thirst is ____ (hypertonic or isotonic) dehydration? hypertonic
Extracellular thirst is ____ (hypertonic or isotonic) dehydration? isotonic
What triggers intracellular thirst? electrolyte concentration too high in ECF
What triggers extracellular thirst? ECF volume too low
Hypovolemia uses ____ receptors to trigger feelings of thirst? (extracellular) baro
Hypertonic dehydration uses ____ receptors to trigger feelings of thirst? (intracellular) osmo
Osmoreceptors are HIGHLY sensitive (T or F) T
Osmoreceptors modify their ____ (electrical/chemical) activity, APs, in response to ECF osmolarity. electrical
Cell shrinkage is signal detected by ____ in contact with osmoreceptors neurons
Hypovolemia triggers blood vessel ____ (constriction/dilation). constriction
Hypovolemia triggers heart rate ____ (increase/decrease). incrfease
Hypovolemia is ___ (intra/extra) cellular thirst and induces cravings for ____. extra, water and salt
Hypertonic dehydration is ___ (intra/extra) cellular thirst and induces cravings for ____. intra, water
___ (carnivores/herbivores) have a deficit of sodium. Herbivores
What are the 3 forms of nitrogenous waste? ammonia, urea, uric acid
What does the urea cycle do? converts ammonia to less toxic urea
The urea cycle is energetically costly. (T or F) T
Ammonia is released through the ____ (whole body surface, kidney, as a paste). whole body surface
Urea is released through the ____ (whole body surface, kidney, as a paste), as ____. kidney, urine
Uric acid is released as a ____ (liquid, solid, paste), which is energetically ____ (costly, favorable). paste, costly
Ammonia is ___ (highly, medium, not very) toxic, requires ___ (high/mid/low) water volume and ___ (high/mid/low) energy. highly, high, low
Urea is ___ (highly, medium, not very) toxic, requires ___ (high/mid/low) water volume and ___ (high/mid/low) energy. medium, mid, mid
Uric Acid is ___ (highly, medium, not very) toxic, requires ___ (high/mid/low) water volume and ___ (high/mid/low) energy. not very, low, high
Urine is made up of 95% ___ and 5% ___ Water, nitrogenous waste and ions
Define excretion filtration and reabsorption along a tube
What are the 4 steps of excretion. 1. filter ECF, reclaim valuable solutes, reabsorb water, secrete toxin
What is the equation for excretion? Excretion = Filtration - Reabsorption + Secretion
What are the 4 steps of excretion. filtration, reabsorption, secretion, excretion
Which tubes connect to the kidney? renal artery and renal vein
What is the input of the kidney? Blood (renal artery)
What are the outputs of the kidney? Blood (renal vein) and Urine (ureter)
The kidney is an assembly of ____. nephrons
What is a nephron? a basic unit of the kidney
Label nephron in order of blood flow. bowman's capsule, proximal tubule, loop of henle, distal tubule, collecting duct
What are the 3 key steps in urine formation? blood filtration, selective reabsorption and secretion, reabsorption of salt and water
Where in the nephron does blood filtration take place? Bowman's Capsule
Where in the nephron does selective reabsorption and secretion take place? Proximal and Distal tubule
Where in the nephron does reabsorption take place? Loop of Henle and Collecting Duct
Where do podocytes exist? Bowman's Capsule
What is a podocyte? a specialized cell that interacts with endothelial cells
What do podocytes do in Bowman's capsule? form a thin, porous membrane in the inner kidney membrane
What is the OUTPUT of Bowman's capsule? primary urine
Colloid oncotic pressure and Capsule pressure ___ (contradict/support) filtration. contradict
____ (oncotic, hydrostatic) pressure supports filtration (pushes blood out of blood into nephron) hydrostatic
Name the inputs and outputs of the proximal tubule: in: H+, NH3 out:bicarbonate, water, salt, K+
In the proximal tubule, filtrate volume ___ (increases/decreases), but remains iso-osmotic to blood. decreases
What stays constant in the proximal tubule? concentration of filtrate
What is countercurrent multiplication? using energy to generate an osmotic gradient to produce a concentrated gradient
What is the countercurrent multiplication metaphor? urine making many U turns in a concentration gradient
In a nephron, osmolarity increases _____ (up to down, down to up). up to down
Where does reabsorption of MOST water and solutes occur? Loop of Henle
What are the 3 segments of the Loop of Henle? 1) descending limb 2) ascending limb 3) thick ascending limb
The descending limb of the Loop of Henle is _____ (permeable/impermeable) to water, ____ (permeable/impermeable) to ions. permeable, impermeable
The descending limb of the Loop of Henle is _____ (permeable/impermeable) to water, ____ (permeable/impermeable) to ions. impermeable, permeable
The thick ascending limb of the Loop of Henle actively _____. pumps out Na+
When the salt concentration increases down the descending loop, water is _____ (gained/lost) lost
In the ascending loop ____ (salt/water) is lost. salt
What is the single effect? horizontal gradient generated
The Loop of Henle goes from a horizontal gradient (___ effect) to a _____ gradient. single, vertical
What are the5 steps of going from single effect to vertical gradient? 1. isosmotic with blood 2. single effect n1 3. filtration, high salt concentration to bottom 4. single effect n2 5. repeat
What happens in step 2 of single effect to vertical gradient? (Single effect n1) salt gets pumped into the middle, decreases osm in ascending, increases in ascending
What enters the distal tubule? dilute urine
What stimulates Na+ reabsorption into the distal tubule? aldosterone
What is aldosterone? what stimulates Na+ reabsorption in the distal tubule.
What are the INPUTS and OUTPUTS of the distal tubule? in: K+, H+ out: NaCl, bicarbonate, H+, K+
In collecting duct, ____, ____-, and _____ are secreted. NaCl, Urea, H2O
In the collected duct, ___ and ____ leave through passive transport, while ____ leaves through active transport. Urea, H2O, NaCl
When urine enters the Loop of Henle, it is ____ (isoosmotic/hypoosmotic) isoostomic
Hypoosmotic to blood is like saying ____ dilute
When urine exits the Loop of Henle, it is ____ (isoosmotic/hypoosmotic) hypoosmotic
Dehydration triggers the release of ____. ADH
ADH promotes urine ____ (concentration/dilution), retaining water. concentration
How does ADH work? It triggers aquaporin accumulation at the membrane surface, facilitating water flux and allowing stronger water absorption
What kind of channel does ADH trigger? aquaporin
_____ (osmoregulators/osmoconformers) match osmolarity of body to outside environment Osmoconformers
_____ (osmoregulators/osmoconformers) can exist outside of marine environments Osmoregulators
Created by: shohumfin
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