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Epidermis
chapter 6- integumentary system
| Term | Definition |
|---|---|
| Epidermis | - outerlayer - stratified squamous epitheliums -cornified or keratizinized to prevent water loss -avascular |
| Functions of Epidermis | - protect against water loss, harmful chemicals, mechanical injury, and pathogens |
| keratinization | - process of hardening, dehydration, and keratin accumulation - occurs in epidermal cells as they migrate outward |
| Keratin | - though, fibrous, waterproof, protein made and stored in cells - made of keratinocytes - form outermost layer, stratum corneum |
| stratum corneum | - location: superio (outermost) layer - characteristics: many layers of keratinized, dead epithelial cell that are flattened and non nucleated |
| Stratum lucidum (only present in thick skin) | - location: between stratum corneum and stratum granulosum on soles and palms - characteristics: cells appear clear; nuclei organelles, and and cell membranes are no longer visible |
| Stratum granulosum | - location: beneath the stratum corneum - characteristics: three to five layers of flattened granular cells that contain shrunken fibers of keratin and shriveled nuclei |
| Stratum spinosum | - location: beneath the stratum granulosum - characteristics: many layers of cells with centrally located, large oval nuclei and developing fibers of keratin; cells becoming flattened |
| Stratum basale | - location: deepest layer - characteristics: a single row of cuboidal or columnar cells that divide and grow; this layer also includes melanocytes |
| dedritic cells | - found in stratum basale -phagocytes; protect skin and underlying tissues from infection |
| tactile cells | - found in stratum basale -act as sensory receptors for light tough |
| melanocytes | - found in stratum basale -produce the pigment melanin - absorbs UV light from sunlight and provides skin color |
| melanin | - distributed to keratinocytes, to protect from UV radiation - Dan damage, fibroblast damage, skin cancer |
| eumelanin | brownish-black pigment |
| pheomelanin | reddish-yellow pigment |
| Skin Color- hereditary factors | - all people have the same amount of melanocytes, the amount of melanin produced is genetic - varying distribution and size of ,melanin granules - albinos inherit mutation in melanin genes; lack melanin |
| skin color- environmental factors | - sunlight - UV light from sun lamps - X-rays |
| skin color- physiological factors | - Oxygenation in blood or dermal vessels - vasodilation' vasoconstriction of formal blood vessels - accumulation of carotene pigment from diet |
| Basal cell carcinoma | - most common skin cancer, nonlethal |
| Squamous cell carcinoma | - rarely deadly cancer |
| Melanoma | - arise from melanocytes - least common (4% of skin cancer) - cause 80% of skin cancer death |