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OAT Biology
Circulatory, Respiratory, Digestive, and urinary systems
| Term | Definition |
|---|---|
| veins | carry deoxygenated blodd back to the heart |
| pulmonary circulation | right side of the heart that pumps deoxygenated blood towards the lungs |
| systemic circulation | left side pumps oxygenated blood throughout the body |
| atria | - two upper chambers of the heart - thin-walled |
| ventricles | - two lower chambers of the heart - more muscular (the left is more muscular than right) |
| blood flow (blood returning from the body ) | superior and inferior vena cava -> right atrium -> tripuspid valve -> right ventricle -> pulmonary semilunar valve -> pulmonary veins -> lungs |
| blood flow (blood returning to the lungs) | pulmonary veins -> left atrium -> bicupsid (mitral) valve -> left ventricle -> aortic semilunar valve -> systemic circulation through the aorta |
| atrioventricular (AV) valves | - located between the atria and ventricles on both sides of the heart - prevent backflow of blood into the atria during contraction |
| tricuspid valve | valve on right side of the heart has 3 cusps |
| bicuspid (mitral) valve | valve on left sige of the heart has 2 cusps |
| semilunar valves | - has 3 cusps - located between the left ventricle and aorta and between the right ventricle and pulmonary atery |
| systole | - period during which the ventricles contract - forcing blood out of the heart into pulmonary and systemic circulation |
| diastole | - period of cardiac muscle relaxation - blood drains into all four chambers |
| systolic blood pressure | measures the pressure in a patient's blood vessels when the ventricles are contracting |
| diasolic blood pressure | measures the pressure during cardiac relaxation |
| cardiac output | the total volume of blood the left ventricle pumps out per minute cardiac output = heart rate x stroke volume |
| sinoatrial (SA) node | - the pacemaker - small mass of specialized tissue located in the wall of the right atrium - spreads impules through both atria stimulating them to contract simutaneously filling the ventricles |
| atrioventricular (AV) node | - slowly conducts impluses to the rest of the heart - allowing enough time for atrial contraction and for the ventricles to fill with blood |
| bundle of His (AV bundle) | - the impulse branches into the right and left bundle branches |
| purkinje fibers | - in the walls of both ventricles - stimulating a strong contraction |
| autonomic nervous system | modifies the rate of heart contraction |
| vagus nerve | - parasympathetic nervous system - causes a decrease in heart rate |
| arteries | - thick-walled, muscular, elastic vessels - transport oxygenated blood away from the heart |
| pulmonary arteries | transport deoxygenated blood from the heart to the lungs |
| veins | - thin-walled, inelastic vessels - conduct deoxygenated blood towards the heart |
| pulmonary veins | carry oxygenated blood from the lungd to the heart |
| capillaries | - very thin walls - composed of a single layer of endothelial cells - have the smallest diameter |
| lymphatic system | - secondary circulatory system - vessels transport lymph to the cardiovascular system keeping fluid levels in the body constant |
| lacteals | - smallest lymphatic vessels - collect fats in the form of chylomicrons from villi in the small intestine - delivers to the bloodstream via the thoracic duct at the subclavian vein bypassing the liver |
| lymph nodes | swellings along lymph vessels containing phagocytic cells |
| lymphocytes | - phagocytic cells that filter the lymph - remove and destroy foreign particles and pathogens |
| oxyhemoglobin | hemoglobin bind up to oxygen |
| carbaminohemoglobin | hemoglobin capable of binding to carbon dioxide |
| antigens | - cell-surface proteins - foreign macromolecules to the host organism - trigger an immune response |
| type A | - antigen A - anti-B antibody - donate A and AB - receive A and O |
| type B | - antigen B - anti-A antibody - donates B and AB - recieves B and O |
| type AB | - antigen A and B - no antibody - donate AB only - universal receiver |
| type O | - no antigen - anti-A and anti-B - universal donor -receive O only |
| Rh fetus | the fetal red blood cells which have the Rh factor enter maternal circulation during |
| erythroblastosis fetalis | - severe anemia in the fetus - not caused by ABO blood type mismatches between mother and fetus |
| transport of nutrients and waste | - amino acids and simple sugars absorbed into the bloodstream at the intestinal capillaries - metabolic waste products (water, urea, and carbon dioxide) diffuse into the capillaries from surrounding cells |
| platelet plug | a chemical that causes neighboring platelets to adhere to one another |
| thromboplastin | clotting factor |
| prothrombin | inactive plasma protein |
| thrombin | aid of its cofactors calcium and vitamin K converts the inactive protein |
| fibrinogen | plasma protein into fibrin |
| fibrin | - threads fibrin coat the damaged area - trap blood cells to form a clot |
| serum | fluid left after blood clotting |
| alveoli | - air-filled sacs at the terminals of the airway branches - provide moist respiratory surface for gas exchange |
| inhalation | - the diaphragm contracts and flattens - the external intercostal muscles contract - the phrenic nerve innervates the diaphragm and causes it contract and flatten - increase in volume in the thoratic cavity -reduce pressure making the lungs expand |
| exhalation | - passive process - lungs and chest wall highly elastic - diaphragm and external intercostal muscles relax - lungs deflate |
| surfactant | - protein complex secreted by cells in the lungs - keeps the lungs from collapsing by decreasing surface tension |
| respiratory centers | - located in the medulla obolongata - regulated ventilation |
| pulmonary capillaries | a dense network of minute blood vessels that srrounds the alveoli |
| gas exchange | diffusion across capillary walls and those of the alveoli |
| total lung capacity | the maximum volume of air the lungs can hold |
| tidal volume | the volume of air moved during a normal resting breath |
| inspiratory reserve volume | - volume of air that could be additionally inhaled into the lungs at the end of a normal resting inhalation - deep breath |
| expiratory reserve volume | the volume of air left in the lungs at the end of a normal resting exhalation |
| vital capacity | the volume of air moved during a maximum inhalation followed by a maximum exhalation |
| residual volume | there is always some air left in the lungs to keep the aveoli patent |
| oral cavity | - mouth - where mechanical and chemical digestion of food |
| mechanical digestion | breakdown of large food particles into smaller particles through physical actions |
| mastication | biting and chewing action of teeth |
| chemical digestion | enzymatic breakdown of macromolecules into smaller molecules |
| saliva | secreted in response to the presence of food in the mouth and serves to lubricate and begin digestion |
| salivary amylase | enzyme which hydrolyzes starch to maltose |
| bolus | swallowed food |
| peristalsis | involuntary muscular contractions of the esophagus |
| lower esophageal sphincter | - esophagus is closed off from the stomach by contraction of a muscular structure - protects the esophagus from the acidic gastric contents |
| gastric mucosa | lines the walls of the stomach |
| mucous cells | - in gastric pits - secrete mucus to protect the stomach lining from the harshly acidic juices present in the stomach |
| chief cells | - in gastric glands - synthesize pepsinogen which is converted to pepsin upon contact with stomach acid and break down proteins |
| parietal cells | - gastric glands -synthesize and release hydrochloric acid which alters the pH of the stomach - kills bacteria and produce intrinsic factor which is necessary for the absorption |
| chyme | acidic semifluid mixture of partially digested food |
| duodenum | - first segment of the small intestine - primary site of digestion |
| jejunum | second segment of the small intestine |
| ileum | third segment of the small intestine |
| liver | accessory digestive organ - produces bile - deoxifies blood - storage of glycogen - conversion of ammonia to urea - protein synthesis - cholestrol metabolism |
| bile | - emulsify fats - breaks down large globiles into small droplets - in absence of bile, fats cannot digested |
| first pass effect | - majority of deoxification - protect the body from ingested toxins |
| pancreas | accessory digestive organ - releases amylase, lipase, and trysinogen - secretes a bicarbonate-rich juice the neutralizes the acidic chyme - pancreatic enzymes operate optimally at higher pH |
| trypsinogen | precursor of trypsin |
| trypsin | a powerful proteolytic enzyme - activated by enterokinase - only activated once it enters the small intestine - cleaves and activates other zymogens |
| large intestine | - approximately 1.5 m long - absorbs salts and any water not already absorded by the small intestine |
| gut flora | symbiotic bacteria that produce vitamins and digest nutrients that the host organism cannot |
| gastrin | - produced in the G cells of the duodenum - primarily functions to stimulate histamine and pepsinogen - stimulates the parietal cells to produce HCl which denatures proteins and activates digestive enzymes |
| intrinsic factor | secretion of parietal cells of the stomach that facilitates the absorption of vitamin B12 across the intestinal lining |
| cholecystokinin (CCK) | - produced and stored in the I cells of the duodenal and jejunal mucosa - involved in stimulation of pancreatic enzyme - gallbladder contraction - hunger suppressant |
| secretin | - synthesized and stored in the S cells of the upper intestine - stimulates the secretion of bicarbonate-containing substances from the pancreas - inhibits gastric emptying and gastric acid production |
| ghrelin | - synthesized both in the brain and the gut - serves as the hunger hormone - increased levels cause increased appetite and feeding behavior |
| leptin | - synthesized primarily in adipose tissue (fat cells) - serves as an antagonist to ghrelin - acts on the brain to reduce hunger and provide a satiated state |
| excretion | removal of metabolic wastes produced in the body |
| aerobic respiration | production of carbon dioxide and water |
| deamination of amino acids | - in the liver - leads to the production of nitrogenous wastes (urea and ammonia) |
| elimination | the removal of indigestible material such a dietary fiber |
| kidneys | - regulate the concentration of salt and water in the blood through the formation and excertion of urine - bean-shaped - located behind the stomach and liver |
| nephrons | million functional units |
| outer cortex | -superficial -contacts fibrous capsule -houses filtration structures (nephrons) |
| inner medulla | Divided into pyramids Each medullary pyramid ends in a papilla |
| renal pelvis | acts as a funnel to drain urine from the kidney to the ureter |
| bowman's capsule | cup-shaped strucutre of the nephron of a kidney which encloses the glomerulus and which filtration takes place. |
| glomerulus | A ball of capillaries surrounded by Bowman's capsule in the nephron and serving as the site of filtration in the vertebrate kidney. |
| proximal convoluted tubule | - first section of the renal tubule that the blood flows through; reabsorption of water, ions, and all organic nutrients - site of secretion for waste products (hydrogen ions, potassium ions, ammonia, and urea) |
| loop of henle | the part of a kidney tubule that forms a long loop in the medulla of the kidney, from which water and salts are resorbed into the blood. |
| distal convoluted tubule | - Between the loop of Henle and the collecting duct - Selective reabsorption and secretion occur here, most notably to regulate reabsorption of water and sodium - responds to aldosterone |
| collecting duct | - the location in the kidney where processed filtrate, called urine, is collected from the renal tubules - responsive to both aldosterone and antidiuretic hormone |
| filtration | - a passive process driven by the hydrostatic pressure of the blood - blood plasma entering the glomerulus through its capillary walls and into the surrounding Bowman's capsule |
| filtrate | - fluid and small solutes entering the nephron - isotonic with blood plasma -particles too large to filter through the glomerulus (blood cells and albumin) remain in circulation |
| secretion | - nephrons secretes waste substances such as acids, ions, and other metabolites from the interstital fluid into filtrate by both passive and active transport |
| reabsorption | - essential substances (glucose, salts, and amino acids) and water are reabsorbed from the filtrate and returned to the blood - occurs primarily in the proximal convoluted tubule passive movement of water results in the formation of concentrated urine |
| ureter | brings urine from the kidney to the urinary bladder |
| urinary bladder | urine collects until expelled via the urethra |
| descending limb of the loop of Henle | - filtrate from the PCT (salt concentration high) - dives deep into the medulla before turning around the opposite way - permeable to only water - water leaves the filtrate (osmosis) as it goes deeper into the medulla |
| osmolarity gradient | - created through the exiting and re-entry of solutes such as Na+ and Cl- at different segments of the nephron - max gradient in humans is 300mOs,/L at the cortex and 1200 mOsm/L in the deep cortex |
| ascending limb of the loop of Henle | - a change in permeability - only permeable to salts and impermeable to water - salt concentration low |
| thick ascending limb of the loop of Henle | - occurs due to the enlargement of the cells lining the tube - increased number of mitchondria, produces additional ATP need to power active transports that pump out Na+ and Cl- from the filtrate |
| countercurrent multiplier system | a system in which energy is used to create a concentration gradient |
| aldosterone | steroid hormone that upregulates active transport of sodium and potassium ions along the distal convoluted tubule and collecting duct |
| antidiuretic hormone | directly affects water reabsorption in the distal convoluted tubule and collecting ducts by opening additional aquaporins |