Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Hematology
Overall by section
| Question | Answer |
|---|---|
| Which cells are infected by EBV? | B cells |
| Which receptor is used by EBV to infect B cells? | CD21 |
| Which virus is known to infect B cells via the CD21 receptor? | EBV |
| What are the PBS findings in Spherocytosis? | Spherocytes |
| Spherocytes and elevated bilirubin reflecting hemolysis. Dx? | Spherocytosis |
| What is the result of the mutation in Hereditary Spherocytosis proteins? | Increased RBC flexibility and homolysis |
| Which skeleton usually has the most active haematopoietically red bone marrow? | Axial skeleton of young adults |
| What is a contraindication to use tPA in a patient with an ischemic stroke? | Blood pressure > 185/110 mm Hg |
| Which genetic process or phenomenon is evidenced by A and B blood types? | Codominance |
| How are the nuclei of PMNs described? | Multilobular and azurophilic nuclei |
| Which type of cells are the first to respond to a gonococcal infection? | PMNs |
| What is the definition of PMNs? | Immune cell that has granules (small particles) with enzymes that are released during infections, allergic reactions, and asthma |
| What are types of PMNs? | Neutrophils, Eosinophils, and basophils |
| On which cells is GpIIb/IIIa receptor found? | Platelets |
| What is the role of GpIIb/IIIa in platelet aggregation? | Binding of fibrinogen molecules after being activated by ADP, thrombin, or collagen |
| What is a severe cutaneous adverse effect of Warfarin? | Warfarin-induced skin necrosis |
| What is inhibited by Warfarin? | Synthesis of the vitamin K-dependent clotting factors II, VII, IX, and X, and proteins S and C |
| Which hematologic measure is increase using Warfarin? | Prothrombin time |
| Does Warfarin affect PT or aPTT? | Prothrombin time |
| What serum abnormalities triad characterizes DIC? | Thrombocytopenia, increase clotting time (PT and aPTT), and decreased clotting factors and increased D-dimers |
| What causes DIC? | Widespread of microthrombi in small vessels |
| Is Multiple Myeloma associated with hyper-or hypocalcemia? | Hypercalcemia |
| What is Multiple Myeloma (MM)? | Neoplastic proliferation of monoclonal plasma cells that produce enormous amounts of IgG, resulting in elevated levels of serum proteins |
| Which Ig is produced in vast amounts in MM? | IgG |
| Which neoplasm is associated with increased amounts of IgG produced by plasma cells? | Multiple Myeloma |
| What are the blood finings of CML? | Leukocytosis, anemia, and basophilia |
| Which translocation is associated with CML? | t (9;22) |
| What is a primary role of Basophils? | Mediate allergic response through IgE receptor activation |
| Which PMN is known to mediate allergic reactions through IgE receptor activation? | Basophils |
| What is the most common presentation of Pulmonary embolism? | Pleuritic chest pain, tachypnea, and often DVT |
| What is the MCC of inherited thrombocytopenia? | Factor V Leiden mutation |
| Which inherited condition is associated the increased risk of recurrent thrombotic events secondary to decreased cleavage of factor V and by protein C? | Factor V Leiden mutation |
| How is Vitamin K deficiency presented? | Easy bruising and a propensity for bleeding, along with increase in PT and PTT |
| Which broad spectrum antibiotics present the highest risk for eventually developing Vitamin K deficiency? | Cephalosporins |
| What is the role or function of Vitamin K? | Carboxylation of glutamine and residues |
| Which vitamin deficiency would lead to impaired carboxylation of glutamine and residues? | Vitamin K deficiency |
| What are the associated levels of Ferritin and TIBC in Iron deficiency anemia? | Decreased MCV and Ferritin, and increased TIBC |
| What is the most likely anemia of an infant that is exclusively breastfed and shows decreased activity? | Iron deficiency anemia |
| What are the histological findings of skin biopsy of Sezary syndrome? | Lymphocytes with "cerebriform" nuclei, and elevated CD4+ count |
| What are the clinical findings of Sezary syndrome? | Erythroderma, generalized lymphadenopathy, and pruritus |
| What are the most common clinical findings of T-cell acute lymphoblastic lymphoma? | Anemia, thrombocytopenia, leukocytosis, a mediastinal mass |
| How are the lymphoblast in T-cell acute lymphoma described in biopsy? | Cells with light-blue, scanty, a nongranular cytoplasm |
| What are the causes of hemochromatosis? | Increased effacing of dietary iron absorption and increased hepatic iron storage |
| What are the main clinical symptoms of Hereditary Hemochromatosis? | Hepatosplenomegaly, weakness, lethargy, and joint pain |
| How is Hemochromatosis confirmed? | Hemosiderin deposits on the liver biopsy |
| Is TIBV increased or decreased in the blood of a patient with Hemochromatosis? | Decreased TIBC |
| Which serum iron-related levels increased in hemochromatosis? | Serum iron and ferritin |
| What is the most common presentation of Follicular lymphoma? | Middle-aged adult with waxing and waning painless lymphadenopathy |
| What is the associated gene (protein) of Follicular lymphoma? | BCL-2 |
| What is the associated translocation of Follicular lymphoma? | t (14;18) |
| What kind of gene is BCL-2? | Antiapoptotic gene |
Created by:
rakomi
Popular USMLE sets