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Pharmacology_tp
Chapter 45
| Question | Answer |
|---|---|
| The transcription phase of viral replication involves the change of ___ to ____ | RNA, DNA |
| The reproduction of viruses in humans requires five steps in what order? | adsorption, penetration, uncoating, replication, transcription |
| Cytomegalovirus is a type of ______ | herpesvirus |
| Hepatitis symptoms include (5) ? | jaundice, fatigue, abdominal pain, nausea, anorexia |
| Herpes simplex is characterized by the formation of _________ | painful vesicles |
| _____ is an acute unilateral and segmental inflammation of the dorsal root ganglion caused by infection with the herpesvirus varicella zoster | herpes zoster |
| Influenza attacks both the ___ and ___ respiratory track | upper, lower |
| _____ is a major cause of respiratory illness in all age groups; highest rates in infants 2-6 months of age | respiratory syncytial virus |
| The largest group of antiviral drugs are the _______ | purine nucleoside analogue drugs |
| Purine nucleoside analogue drugs have relatively selective toxicity to viruses because viral DNA polymerases are more ____ than human polymerases to inhibition by these drugs | sensitive |
| Whats the prototype drug for the purine nucleoside analogue drugs? | acyclovir (Zovirax) |
| Acyclovir is for the treatment of _____ | herpesviruses |
| What 3 ways is acyclovir monitored? | topical, oral, IV |
| Acyclovir undergoes ______. In an infected cell, it is converted by the viral enzyme ____ ___. Once incorporated into the virus, it terminates it terminates DNA synthesis. | phosphorylation, thymidine kinase |
| When administering acyclovir, use caution in patients with ____ hypersensitivity | ganciclovir |
| What are 6 adverse effects of acyclovir? | lightheadedness, anorexia, nausea, vomiting, abdominal pain, headache |
| Acyclovir has 4 drug interactions with what? | valproic acid, hydantoins, theophyllines, probenecid |
| When administering acyclovir, monitor the function of ____ | kidneys |
| Acyclovir is pregnancy category ___ | C |
| Administer acyclovir tablets or capsules with a full glass of water, with or without ___ | food |
| When taking acyclovir, advise patient to drink at least ____ 8oz glasses of water a day | 8 |
| Administer IV acyclovir over ___ minutes | 60 |
| When giving acyclovir, document new ___ and assess for possible _______ infections | lesion, secondary bacterial |
Created by:
theresa9133
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