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TT2 Vit B-12

TT2 NHCC Vitamin B-12

QuestionAnswer
What is an example of B-12? Cyanocobalamin
What is the action of B-12? 1. Required for many metabolic pathways – including fat and carbohydrate metabolism and protein synthesis 2. Required for growth, cell replication, hematopoiesis and nucleoprotein and myelin synthesis (integrity of normal nerve function)
What is B-12 used for? deficiency due to insufficient intake, malabsorption syndromes
What are the MAJOR SIDE EFFECTS / ADVERSE REACTIONS of B-12? 1. Nontoxic, large doses must be ingested to produce side effects: Itching, transitory diarrhea and fever, heart failure, peripheral, vascular thrombosis, pulmonary edema, rash, pain at injection site, Flushing, optic nerve atrophy, hypokalemic
What are the contraindications? Known drug product allergy - - e.g. cobalt
What is needed for the absorbtion of B-12? intestinal absorption requires presence of intrinsic factor in terminal ileum
Where is B-12 stored? principally stored in liver, kidneys and adrenals
How is it metabolized? Converted in tissues to active co-enzymes; enterohepatic cycled
How is it eliminated? in urine
What are the interactions? Use with anticonvulsants, aminoglycoside antibiotics or long-acting potassium preparation decreases the oral absorption. Chloramphenicol antagonizes the hematologic response
What lab tests should be done at the initiation of B-12 therapy and on a regular basis during therapy? reticulocyte and erythrocyte counts, Hgb, Hct, vitamin B12, serum folate levels should be determined
What are 2 nursing dx to use with B-12 therapy? 1.Imbalanced nutrition: less than body requirements, 2. Knowledge deficit r/t nutrition, diet
Created by: 2007Nurse
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