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TT2 Anti-Thyroid
TT2 NHCC Anti-Thyroid Drugs
| Question | Answer |
|---|---|
| What are examples of Anti-Thyroid Drugs? | methimazole, propylthiouracil |
| What is the action? | Inhibits synthesis of thyroid hormones |
| What are side effects and adverse reations? | Hypothyroidism, Liver & bone marrow toxicity, urticaria, pruritus, skin pigmentation, headache, neuritis, paresthesias, N/V, epigastric distress, nephritis, agranulocytosis, arthralgia |
| What are the contraindications? | Known drug allergy, Avoid in pregnancy when possible especially third trimester, Caution in use for patients with liver disease, infections, or bone marrow disease |
| What are the PHARMACOKINETICS? | Rapidly absorbed, Distribution: crosses placenta, enters breast milk in high concentrations, Metabolized in the liver, Excreted via the kidneys |
| What are the interactions? | May reduce effects of Warfarin (anticoagulant), May increase serum levels of Digoxin, Use with bone marrow depressants can ↑ development of agranulocytosis,Use with oral anticoagulants may ↑ their activity |
| What are 3 possible nursing dx? | Activity intolerance, Risk for injury, Acute pain |
| What are 2 planning considerations? | P.O. – Administer with meals at equal intervals around clock, Avoid exposure to light in storage |
| What can use with bone marrow depressants do? | can increase development of agranuloccytosis |
| What GI side effects can be experienced? | N/V, epigastric distress |
| What can be done to decrease GI side effects? | Administer with meals |
| What would be a reason to teach a patient to notify the MD? | skin rash, swollen neck glands |
Created by:
2007Nurse
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