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83 — ATI Ch. 8

Depressive Disorders

QuestionAnswer
What type of drug is Fluoxetine? SSRI
Therapeutic uses of Fluoxetine? depression, OCD, bulimia, PMS, panic disorders, PTSD, anxiety disorders, bipolar
AE of Fluoxetine CNS stimulation, weight loss, serotonin syndrome. withdrawal, hyponatremia, rash, sleepiness, faintness, lightheadedness, GI bleeding, bruxism
When does serotonin syndrome begin? 2-72 hr after treatment
CI for Fluoxetine? pregnancy, MAOI/TCA usage, liver/renal dysfunction, CV disease, seizures, diabetes, ulcers, GI bleed hx
Ixns with Fluoxetine? TCAs, MAOIs, St. John's wort, warfarin, trcyclics, NSAIDs, anticoagulants
What type of drug is Venlafaxine? SNERI
Example of SNERI? Venlafaxine
MOA of Venlafaxine? block reuptake of both NE & serotonin
Tx for Venlafaxine? depression, panic disorder, social anxiety, GAD, pain due to chronic illness
AE of Venlafaxine? nausea, anorexia, headache, insomnia, anxiety, HTN, TCA, dizziness, blurry vision, withdrawal, adolescent suicide, impotence, serotonin syndrome
CI for Venlafaxine? pregnancy, breastfeeding, SSRI/MAOI/TCA usage, elderly, bipolar, seizures, lung/heart disease
Ixns with Venlafaxine? MAOIs, NSAIDs, alcohol, CNS depressants, Kava, Valerian, St. John's wort
What type of drug is Bupropion? Atypical antidepressant
Example of an atypical antidepressant? Bupropion
MOA of Bupropion? blocks reuptake of NE & dopamine
Tx of Bupropion? depression, SSRI-related impotence, smoking cessation, seasonal depression, ADD
AE of Bupropion? headache, dry mouth, N/V, constipation, tachycardia, HTN, restlessness, insomnia, anorexia, seizures
CI for Bupropion? MAOI usage, seizures, eating disorders
Ixn for Bupropion? MAOI
What type of drug is Vilazodone? atypical antidepressant
MOA of Vilazodone? serotonin blockers & agonist
What food to avoid when taking Vilazodone? grapefruit juice
How to increase absorption of Vilazodone? take with food
MOA of Mirtazapine? increase release of serotonin & NE
MOA of Nefazodone? selective inhibition of serotonin & NE reuptake
MOA of Trazodone ER? selective serotonin blockade
What's special about Trazodone ER? usually used with another antidepressant
Important AE of Trazodone ER? priapism
What food to avoid when taking Trazodone ER? grapefruit juice
What type of drug is Amitriptyline? tricyclic antidepressant
MOA of Amitriptyline? block reuptake of NE & serotonin
AE of Amitriptyline? orthostatic HOTN, anticholinergic effects, sedation, toxicity, seizure, sweating
CI for Amitriptyline? pregnancy, breastfeeding, any chronic disease of any body system, prostatic hyperplasia, hyperthyroidism, suicide
What type of drug is Phenelzine? MAOI
MOA of Phenelzine? increase amounts of NE, dopamine, serotonin, tyramine
AE of Phenelzine? CNS stimulation, Orthostatic HOTN, HTN, local rash
CI for Phenelzine? heart problems
Created by: arbaskett
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