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83 — ATI Ch. 7

ATI Pharm Exam

QuestionAnswer
What type of drug is Alprazolam? sedative hypnotic benzodiazepine
MOA of Benzodiazepines? enhance GABA effect in CNS
How soon do Benzodiazepines relieve anxiety? rapidly following admin
How long should Benzodiazepines be used and why? short-term use due to dependence potential
Therapeutic use of Benzodiazepines? generalized anxiety, panic disorder
Example of Benzodiazepines? Alprazolam
AE of Benzodiazepines? CNS depression (sedation, light-headedness, ataxia, decreased cognition), anterograde amnesia
Treatment for oral Benzodiazepines toxicity? gastric lavage
Treatment for general Benzodiazepines toxicity? flumazenil admin
How should a patient stop taking Benzodiazepines? taper the dose over several weeks
CI for Benzodiazepines? pregnancy, breastfeeding, sleep apnea, respiratory depression, glaucoma, liver disease, substance abuse
What diet education for Benzodiazepines should be provided? no grapefruit juice or high-fat foods
When should Benzodiazepines be administered and why? at night due to sedation effects
What type of drug is Buspirone? atypical/nonbarbiturate anxiolytic
Example of atypical/nonbarbiturate anxiolytic? Buspirone
MOA of Buspirone? binds to serotonin & dopamine receptors
Important differentiation of Buspirone? no risk of misuse, sedation, or CNS depressant potentiation
How soon does Buspirone relieve anxiety? 2-4 weeks for full effects
What is the dosing schedule for buspirone? scheduled basis, not PRN compatible
Therapeutic use of Buspirone? most all anxiety disorders
AE of Buspirone? dizziness, nausea, headache, lightheadedness, agitation, constipation
CI for Buspirone? pregnant breastfeeding, elderly, liver/renal disorder, MAOI antidepressant usage
Ixns of Buspirone? erythromycin, ketoconazole, St. John's wort, grapefruit juice increase its effects
What diet education for Buspirone should be provided? take it with food to prevent nausea
What type of drug is Paroxetine? SSRI
Example of SSRI? Paroxetine
MOA of SSRIs? selective inhibition of serotonin reuptake
How soon do SSRIs reduce anxiety? 4 weeks
Therapeutic uses of SSRIs? most all anxiety disorders, depressive disorders, dissociative disorders, adjustment disorders
Early AE of SSRIs? nausea, DIAPHORESIS, tremor, fatigue, drowsiness
Late AE of SSRIs? insomnia, headache, sexual dysfunction, weight gain, GI bleed, serotonin syndrome, bruxism
CI for SSRIs? MAOI/TCA usage, alcohol, liver/renal dysfunction, seizures, GI bleeds
Ixns of SSRIs? St. John's wort, MAOIs, TCAs, antiplatelets, anticoagulants
What diet education for SSRIs should be provided? take with food
What is the dosing schedule of SSRIs and why? same time every day (to maintain levels) in the morning (to prevent sleep disturbances)
Created by: arbaskett
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