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Cell-cell interactio
| Question | Answer |
|---|---|
| Tight junctions | seal cells together prevents passage of molecules between cells. found in epithelial cells(intestines, lungs) |
| Desmosomes | connect the cytoskeletons of cells in tissues that experience intense mechanical stress |
| Gap junctions | act as channels between cells allows direct communication between cells |
| Plasmodesmata | gaps in cell walls no proteins involved |
| cell-cell signaling | distant communication hormones are an example. |
| Four steps of cell-cell signaling | 1. signal reception, 2. signal processing(Transduction), 3. signal response 4. Signal deactivation |
| 1. signal reception | the proteins change shape and activity after binding to a signal molecule its different for lipid-soluble vs. lipid-insoluble molecules |
| lipid soluble molecules | can easily diffuse across cell membrane binds to receptors in the cytosol |
| lipid-insoluble molecules | can't diffuse across cell membrane receptor is located on plasma membrane instead of direct response, it must trigger signal transduction |
| 2. signal transduction | conversion of one signal to another aka second messenger |
| what are some examples of signal transduction? | second messengers phosphorylation cascade |
| Second messenger | small molecule that elicits an intracellular response cAMP- activates kinases(can add phosphate groups) Ca2+- muscle contraction |
| Phosphorylation cascade | each kinase phosphorylates a different kinase until a response is triggered |
| 3. signal response | 1. it can change gene expression( bind to DNA to either increase/decrease protein production) 2. change the activity of proteins in cells |
| 4. signal deactivation | final step of cell-cell signaling which deactivates the reaction |
| How do G proteins inactivate? | they inactivate themselves after GTP hydrolysis(adds water to break bonds) |
| How do phosphorylation cascades inactivate? | phosphatases remove phosphate groups from components |
| How do second messengers inactivate? | Ca2+- the membrane pumps return to storage cAPM, the enzymes break down |