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ACEIs 2

action--side effects on body systems

TermDefinition
ACEIs are absorbed __________ from the intestine. fairly rapidly
ACEIs are well distributed and progress rapidly and extensively to active metabolism after__________________. extensive first-pass effects
Where are ACEIs excreted? hepatic clearance is the main route of any *unchanged* drug metabolites found in feces and urine
Most ACE inhibitors are eliminated mainly by the _______ and to a lesser extent through the liver kidneys
first pass phenomenon of drug metabolism whereby the concentration of a drug, specifically d orally, is greatly reduced before it reaches the systemic circulation
ACEIs half-life varies widely
ACEIs CV side effects postural hypotension, first dose hypotension likely with ACEIs
ACEIs derm side effects rash
ACEIs GI S/E N/V/D
ACEIs GU S/E impotence
ACEIs heme S/E leukopenia
ACEIs metabolic S/E HYPERLALEMIA!!!
ACEIs neuro S/E h/a, dizziness, fatigue, somnolence
ACEIs pulmonary S/E persistent dry cough
ACEIs GI S/E N/V/D
Renal function can ___________ acutely when ACE inhibitor therapy is initiated deteriorate-- renal dysfunction can occur due to a drop in renal perfusion pressure and subsequent decrease in glomerular filtration.
ACEIs renal S/E increased serum creatinine, renal failure, oligohydramnios
ACE inhibitors effectively _________systemic vascular resistance in patients with hypertension, heart failure or chronic renal disease. reduce--accounts for an important part of their long term renoprotective effects in patients with diabetic and non-diabetic renal disease
Created by: nikkimb99
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