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ACEIs 2
action--side effects on body systems
Term | Definition |
---|---|
ACEIs are absorbed __________ from the intestine. | fairly rapidly |
ACEIs are well distributed and progress rapidly and extensively to active metabolism after__________________. | extensive first-pass effects |
Where are ACEIs excreted? | hepatic clearance is the main route of any *unchanged* drug metabolites found in feces and urine |
Most ACE inhibitors are eliminated mainly by the _______ and to a lesser extent through the liver | kidneys |
first pass | phenomenon of drug metabolism whereby the concentration of a drug, specifically d orally, is greatly reduced before it reaches the systemic circulation |
ACEIs half-life | varies widely |
ACEIs CV side effects | postural hypotension, first dose hypotension likely with ACEIs |
ACEIs derm side effects | rash |
ACEIs GI S/E | N/V/D |
ACEIs GU S/E | impotence |
ACEIs heme S/E | leukopenia |
ACEIs metabolic S/E | HYPERLALEMIA!!! |
ACEIs neuro S/E | h/a, dizziness, fatigue, somnolence |
ACEIs pulmonary S/E | persistent dry cough |
ACEIs GI S/E | N/V/D |
Renal function can ___________ acutely when ACE inhibitor therapy is initiated | deteriorate-- renal dysfunction can occur due to a drop in renal perfusion pressure and subsequent decrease in glomerular filtration. |
ACEIs renal S/E | increased serum creatinine, renal failure, oligohydramnios |
ACE inhibitors effectively _________systemic vascular resistance in patients with hypertension, heart failure or chronic renal disease. | reduce--accounts for an important part of their long term renoprotective effects in patients with diabetic and non-diabetic renal disease |