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pathophar exam finaL

chapter 93 ANTIVIRALS 92 ANTIFUNGAL

QuestionAnswer
VIRUS RELICATED THROUGH HOSST CELL HARD TO SUPPRESS W/O HARMING HOST ANTIVIRAL VIRAL SUPPRESS THE BIOCHEMICAL PROCESS OF VIRAL REPLICATION
TEACHING-ACYCLOVIR(ZOVIRAX) ACTIVE ONLY A/G MEMBERS OF HERPES SIMPLEX VIRUS OR VARICELLA-ZOSTER VIRUS-SIMPLEX GENITALIS(COLD SORES) HAS RESISTANCE TO ACYCLOVIR VARICELLA ZOSTER REACTIVATE A/G NERVE =SHINGLES
TEACHING ORAL THERAPY *GI-NVD AND VERTIGO TOPICAL THERAPY STINGING ADR IV THERAPY PHLEBITIS, REVERSIBLE NEPHROTOXICITY, NEUROTOXICITY
TEACHING TOPICAL HERPES LABIALIS(COLD SORE) DOCUSANOL OCCULAR HERPES VIROPTIC-EYE DROP GANCICLOVIR-GEL
Hepatitis C Chronic, Leading cause for herpes virus Leading reason of liver transplant
Teaching Transmitted through blood exchanges I.e sexual Transmissible in incubation phase Slow progression = liver failure, cancer, death Drug-ribavarin +interferon Alfa
Hepatitis B 11,000 hospitalized for jaundice, deep fatigue and muscle pain
Teaching Chronic in 3-5% Lead to cirrhosis, hepatic failure , hepatocellular carcinoma, death Transmitted through blood and semen Take vaccine to prevent
Influenza (flu) Severe respiratory tract infection Major cause of mortality and mobility worldwide Influenza virus Mutated randomly, evolve constantly Type A more infectious than B
Teaching Live-used in nose spray-not given to immunocompromised patients Prevent with vaccination Vaccine-depends on yearly strains Inactivated-can’t cause flu(immune response-develop antibiotics and low fever) Live attenuated Begin protection1-2 weeks after and last 6months Small risk for guillan-barre syndrome
TEACHING CAUTION ACUTE FEBRILE ILLNESS-DEFER VACCINATION EGG ALLERGY VACCINATE EXTREME IN AGE-WEAK IMMUNE SYSTEM GIVEN IN THE FALL
TEACHING NEURAMINIDASE INHIBITORS OSELTAMIVIR (TAMIFLU) DOSE FOR PROPHYLASIS AND SICK OF FLU--MUST BE STARTED 48H OR EARLIER AFTER ONSET
RESPIRATORY SYNCYTIAL VIRJUS INFECTION RIBAVIRIN(INHALED) BROAD SPECTRUM ANTIVIRAL DRUG PALIVIZUMAB(SYNAGIS) MONOCLONAL ANTIBODY , PREVENT RSV IN NEWBORNS
A patient is prescribed acyclovir [Zovirax] by mouth. The nurse should assess the patient for which adverse effects associated with oral acyclovir therapy? Stomatitis and gastritis B.Nausea, vomiting, and diarrhea C.Hives, difficulty breathing, and angioedema D.Tinnitus and decreased hearing
A patient asks the nurse what he can do to prevent influenza. What should the nurse do? Instruct the patient to obtain an influenza vaccination.
Which statement about oseltamivir [Tamiflu] does the nurse identify as true? Oseltamivir can be used to treat and prevent influenza.
ANTIFUNGAL SYSTEMIC MCOSES DIFFICULT TO TREAT=RESISTANCE PROLONGED THERAPY TOXIC
SYSTEMIC MYCOSES OPPORTUNISTIC IMMUNOCOMPROMSED HOST-CANDIDIASIS NONOPPORTUNISTIC HAPPEN IN ANY HOST
TEACHING USES DRUG OF CHOICE FOR SYSTEMIC MYCOSES SYSTEMIC FUNGAL INFECTION WERE FATAL BEFORE THIS DRUG BROAD-SPECTRUM AGAINT FUNGAL OR PROTOZOA INFECTION HIGHLY TOXIC INFUSION OR RENAL DAMAGE-IV, NO PO
TEACHING ADR BONE MARROW SUPPRESSION NEPHROTOXICITY KYPOKALEMIA AVOID NEHROTOXIC DRUG(AMINOGLYCOSIDE, NSAID) MONITOR CBC-WBC SERUM CREATINE Q3-4D REDUCE DOSAGE IF >3.5MG/DL
AZOLES BROASD SPECTRUM ALTERNAIVE OF AMPHOTERICIN B
TEACHING PO LOWER TOXICITY INHIBIT P450 DRUG-METABOLIZNG ENZYME INCREASE DRUG LEEL OF OTHER DRUGS
FLUCONAZOLE(DIFLUCAN) PO FUNGISTATIC SAME AS ITRACONAZOLE-IV , WELL BY PO HEADACHE, N/V/D
SUPERFICIAL MYCOSIS CAUSED BY CANDIDIA THRUSH-DIAPER RASH-SKIN FOLD CHRONIC SCALP, SKIN, NAIL DERMATOPHYTIC INFECTIONS(RINGWORM) TINEA-PEDIS, CORPORIS, CRUSIS(GROIN) CAPITIS(SCALP)
TEACHING PO THRUSH VULVOVAGINAL CANDIDIASIS 75% WOMEN QYEARLY RISK FACTORS PREGNANCY, DIABETES, HIV, ORAL
TEACHING-CHANGE TOOTH BRUSH AND LIP GLOSS VULVOVAGINAL CANDIDIASIS 1-3 DAYS TOPICAL OTD-FLUCONAZOLE ORAL NYSTATIN-4-6H SWISH AND SALLOW DO NOT EAT AFTER THIS DRUG TABLET=KETOCAZOLE OR FLUCONAZOLE
ONYCHOMYCOSIS FUNGALINFECTION OF THE NAIL PO LAMISIL AND ITRACONAZOLE -MONITOR AST HEPATOXICITY TOPICAL CICLOPIROX
NYSTATIN POLYENE ANTIBIOTIC ONLY CANDIDIASIS DRUG OF CHOICE FOR INSTESTINAL CANDIASIS-SKIN,MOUTH,ESOPHAGUS, VAGINA PO, TOPICAL
A patient is receiving amphotericin B to treat a systemic fungal infection. To prevent renal damage, it is most important for the nurse to do what? Administer 1000 mL of 0.9% saline. Kidney damage can be minimized by infusing 1 L of saline on the days amphotericin is infused.
Which statement by a new nurse about intravenous administration of amphotericin B indicates the nurse needs more education? Diphenhydramine plus acetaminophen can minimize rigors associated with amphotericin B therapy. TRUE Heparin can be used in the infusion site to prevent phlebitis associated with amphotericin B therapy Meperidine or dantrolene is used to treat rigors associated with amphotericin B therapy.
Created by: Seka_nurse
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