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Adrenergic Receptor

Location of Adrenergic Receptors and Effetcs of Stimulation

Receptor- Alpha 1 Response to Stimulation: Constriction- Aterioles and Veins, Mydrias- Eye, Ejaculation- Penis
Receptor- Alpha 2 Presynaptic terminals inhibition*
Receptor- Beta 1 Increased HR- Heart, Increased Conductivity- Heart, Increased Automaticity- Heart, Increased Contractility- Heart, Renin Release- Heart
Receptor- Beta 2 Bronchodialation- Lungs, Dialation- Arterioles, Inhibition of Contractions- Uterus, Tremors- Skeletal Muscle
Receptor- Dopaminergic Vasodialation (increased blod flow)- Kidney
Synapse Between two nerves
Nueroeffector Junction Specialized synapse bewteen a nerve cell and the organ or tissue it innervates
Neurotransmitter Chemical messenger that conducts a nervous impulse across a synapse
Cholinergic Pertaining to the neortransmitter acetylcholine
Adrenergic Pertaining to the neurotransmitter nor-epinephrine
Parasympathomimetic Drug or other substance that causes effects like those of the parasympathetic nervous system (also called cholinergic)
Parasympatholytic Drug or other substance that blocks or inhibits the actions of the parasympathetic nervous system (also called anticholinergic)
Effects of Atropine overdose? Hot as hell, Blind as a bat, dry as a bone, red as a beet, mad as a hatter
Ipratropium Bromide (Atrovent) , an inhaled anitcholinergic, is effective in treating asthma because why? It relaxes the smooth muscle and causes bronchodialation
Neuromuscular Blocking Agents They produce a state of paralysis without affecting conciousness
Neuromuscular Blocking Agents can be? Non-depolarizing or Depolarizing depending on their mechanism of action
There is only one DEPOLARIZING neuromuscular blocker, what is it? Succinylcholine (Anectine)
Succinylcholine (Anectine) has the shortest onset and duration of action beacause? It has a naturally occurring enzyme, pseudocholinesterase, which degrades it
Sypathomimetic Drug or other substance that causes effects like those of the sympathetic nervous system
Sypatholytic Drug or other sustance that blocks the actions of the sympathetic nervous system
Common Catecholamines- (Natural) Epinephrine, Norepinephrine and Dopamine
Common Catecholamines- (Synthetic) Isoproterenol and Dobutamine
Norepinephrine acts on what receptors? Alpha 1, Alpha 2, Beta 1
Epinephrine acts on what receptors? Alpha 1, Alpha 2, Beta 1, Beta 2
Dobutamine acts on what receptors? Beta 1
Dopamine acts on what receptors? Beta 1, Dopaminergic
Terbutaline acts on what receptors? Beta 2
The drugs to treat cardiovascular disease generally fall into two broad functional classifications? Antidysrhythmics and antihypertensives
Sodium Channel Blockers (Class I) have what effect on the heart? They slow the propagation of impulses down to the specialized conduction system of the atria and ventricles, although it does not affect the SA or AV nodes
Sodium Channel Blockers have what other effects? They slowing the conduction, these drugs also decrease the repolarization rate. This widens the QRSc and prolongs the QT interval
Lidocaine (Class IB) has what effect? It increases the rate of repolarization. It also reduces automaticity in the ventricular calls, which makes it effective in treating rhythms originating from ectopic venticular foci.
Lidocaine is the drug of choice for what two arrhythmia's Ventricular Tachycardia and Ventricular Fibrillation
When Lidocaine is given in overdose it has what effects? It has significant CNS side effects including tinnitus, confusion, and convulsions
Beta Blockers (Class II) have what effect on the heart? Beta 1 receptor in the heart is attached to the calcium channels. Blocking the beta1 recpetors thus blocks the calcium channel and prevents the gradual influx of calcium in phase 0 of the slow potential. Almost the same effect as CCB's
Potassium Channel Blockers (Class III) have what effect on the heart? Check on this
Calcium Channel Blockers (Class IV) have what effect on the heart? They decrease teh SA node and AV node automaticity, most of their usefulness arises from decresing conductivity through the AV node. They effectively slow the ventricular conductivity of AFib and Aflutter
Miscellaneous Antidysrhythmics...name 3 we use? Adenosine, Digoxin and Magnesium Sulfate
Adenosine has what effect on the heart? It acts on both potassium and calcium channels, increasing potassium efflux and inhibiting calcium influx. This results in hyperpolarization that effectively slows the conduction of slow potentials found in the SA and AV nodes.
Digoxin has what effect on the heart? It decreases the intrinsic firing rate in the SA node, whereas it decreases conduction velocity in the AV node. It increases contractility
Magnesium Sulfate has what effect on the heart? It is the drug of choice for torsades de pointe and it's action is not known, it may act on the sodium or potassium channels or on Na++K+ATPase
Antihypertensive are classified as what? Diuretics, Beta-blockers and antiadrenergic drugs, ACE inhibitors, Calcium Channel Blockers, Direct Vasodialators
Which antihypertensive drugs are most prescribed? Diuretics and Beta-blockers and are effective in many patients
Created by: robillard.james