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Gastrointestinal

FA complete review part 1 Embryology and Anatomy

QuestionAnswer
The foregut is extended from the_________________ to the ___. Esophagus to the Upper duodenum
What is covered by the Midgut? Lower Duodenum to proximal 2/3 of transverse colon
What is the extent of the hindgut? Distal 1/3 of transverse colon to anal canal above the pectinate line.
Esophagus -----> Upper duodenum Foregut
Lower Duodenum----> Proximal 1/3 of transverse colon Midgut
What structure covers the distal 1/2 of transverse colon to to anal canal above pectinate line? Hindgut
In respect to the Midgut development in embryo, what occurs at the 6th week of gestation? Physiologic midgut herniates through umbilical ring
What ring (structure) is used by embryological midgut to herniate during early gestational development? Umbilical ring
What happens to midgut at the 10th week of development? Midgut returns to abdominal cavity + rotates around superior mesenteric artery (SMA) total 270 degrees counterclockwise
Embryological midgut develops around which vessel? Superior Mesenteric Artery (SMA)
What direction does the developing midgut rotate? 270 degrees counterclockwise around the SMA
What are Ventral wall defects due? Developmental defects due to failure of rostral fold closure, lateral fold closure, or caudal fold closure.
What are the example condition of rostral fold closure failure? Sternal defects (ectopia cordis)
What is defective in embryogenesis for development of Ectopia cordis? Failure of rostral fold closure
What are examples of conditions due to lateral fold closure during embryogenesis? Omphalocele and Gastroschisis
Omphalocele and Gastroschisis are due to? Failure of lateral fold closure during gestation
What kind of embryological developmental failure lead to bladder exstrophy? Failure of caudal fold closure
Etiology of Gastroschisis Extrusion of abdominal contents through abdominal folds (typical right of umbilicus)
Which ventral wall defect is characterized by abdominal contents outside of body without coverage by peritoneum or amnion? Gastroschisis
What is Omphalocele etiology? Failure of lateral walls to migrate at umbilical ring leading to persistent midline herniation of abundant contents into umbilical cord.
Which condition has its abdominal contents outside body and covered by peritoneum? Omphalocele
Which are important associations of Omphalocele? 1. Congenital abnormalities (trisonomies 13 and 18, Beckwith-Wiedemann syndrome) 2. Structural abnormalities (cardiac, GU, and neural tube)
Abdominal contents covered by peritoneum newborn. Dx? Omphalocele
Which fold failed to close during GI development in Gastroschisis and Omphalocele? Lateral fold
What is Congenital umbilical hernia due to? Failure of umbilical ring to close after physiologic herniation of the intestines
Failure of umbilical ring to close after the intestines herniated. Dx? Congenital umbilical hernia
What are the Tracheoesophageal anomalies? 1. Esophageal atresia (EA), and, 2 Tracheoesophageal fistula (TEF)
What is the most common Tracheoesophageal anomaly? EA with distal TEF
Esophageal atresia with distal Tracheoesophageal fistula is the Most common Tracheoesophageal anomaly.
What is often presented with EA with distal TEF? Polyhydramnios in utero.
What is the reason of the polyhydramnios in utero of a neonate with EA with distal TEF? Due to inability to fetus to swallow amniotic fluid
What are the most common clinical signs of a neotan with a Tracheoesophageal anomalies? Drool, choke, and vomit with first feeding.
Which tracheoesophageal anomaly allows for air to enter the stomach? Tracheoesophageal fistula
What is the clinical test to diagnose Tracheoesophageal anomalies? Failure to pass nasogastric tube into stomach
Why is Pure TEF also called H-type? The fistural conecting the esophagus to the trachea creates a form the remembles the letter "H"
What is the typical clinical presentation of Intestinal atresia? Bilious vomiting and abdominal distension within the first 1-2 days of life.
Duodenal atresia is due to: Failure to recanalize
What are associations of Duodenal atresia? 1. "Double bubble" on X-ray 2. Down syndrome
Jejunal and ieald atresia sure due to: Disruption of mesenteric vessels leading to ischemic necrosis and segmental resorption
What is another way to describe segmental resorption in Jejunal and Ileal atresia? Bowel discontinuity or "apple peel"
Apple peel intestines refer to: Jejunal and ileal atresias
What causes ileal and jejunal atresia to develop "apple peel" appearance? Ischemic necrosis leading to segmental resorption
Hypertrophic pyloric stenosis is the MCC of: Gastric outlet obstruction in infants
What are some key features of Pyloric stenosis ? 1. Palpable olive-shaped mass in epigastric region 2. Visible peristaltic waves 3. Nonbilious projectile vomiting at ~2-6 weeks old
What antibiotic exposure increases the risk of developing hypertrophic pyloric stenosis? Macrolides
What is the electrolyte imbalance seen in Pyloric stenosis? Hypokalemic Hypochloremic Metabolic Alkalosis
Why is the reason for the Hypokalemic hypochloremic metabolic alkalosis in Pyloric stenosis? Secondary to vomiting of gastric acid and subsequent volume contraction.
What are the findings of US in Pyloric stenosis? Thickened and lengthened pylorus
The pancreas is derived from the _______________. Foregut
What do the ventral pancreatic buds contribute for? Uncinate process and main pancreatic duct
What is to become of the dorsal pancreatic bud? Body, tail, isthmus, and accessory pancreatic duct
Which pancreatic bud(s) contribute to development of Pancreatic head? Both, the ventral and dorsal buds.
What is Annular pancreas? Abnormal rotation of ventral pancreatic bud forms a ring of pancreatic tissue around the second part of the duodenum.
What are some possible symptoms of Annular pancreas? Duodenal narrowing and vomiting
What fails in order to develop Pancreas divisum? Ventral and dorsal parts fail to fuse at 8 weeks
Where does the spleen arises from? Mesentery of stomach but has foregut supply (celiac trunk --> splenic artery).
What is included in retroperitoneal structures? GI structures that lack a mesentery and non-GI structures
Injuries to the retroperitoneal structures cause: Blood or gas accumulation in retroperitoneal space
Mnemonic used to remember Retroperitoneal structures SAD PUCKER
What does SAD PUCKER stand for? Retroperitoneal structures: Suprarenal (adrenal) glands Aorta and IVC Duodenum (2nd to 4th parts) Pancreas (except tail) Ureters Colon (descending and ascending) Kidneys Esophagus (thoracic portion) Rectum (partially)
What part of the doudenum is in the retroperitoneal space? 2nd to 4th parts
Which parts of the colon are retroperitoneal structures? Descending and ascending colon
Which part of the Pancreas is NOT found in the retroperitoneal space? Tail
Which glands are retroperitoneal? Suprarrenal or Adrenal glands
What is connected by the Falciform ligament? Liver to anterior abdominal wall
What ligament connects the liver to the anterior abdominal wall? Falciform ligament
What structures are found/contained by the Falciform ligament? 1. Ligamentum teres hepatis 2. Patent paraumbilical veins
Which ligament is known to be derivative of Ventral mesentery? Falciform ligament
The hepatoduodenal ligament connects the: Liver to duodenum
Which GI ligament is known to connect the liver and the doudenum? Hepatoduodenal ligament
Which ligament contains the Portal triad? Hepatoduodenal ligament
What are the components of the Portal triad contained by the Hepatoduodenal ligament? Proper hepatic artery, Portal vein, and common bile duct
What is the Pringle manuever? It is when the Hepatoduodenal ligament is compressed between thumb and index finger placed in omental foramen to control bleeding.
Which foramen is bordered by the Hepatoduodenal ligament? Omental foramen
Which is a common maneuver used to stop bleeding by pressing on the Hepatoduodenal ligament? Pringle manuever
The liver to lesser curvature of stomach is connected by the: Gastrohepatic ligament
Which structures are contained by the Gastrohepatic ligament? Gastric vessels
What ligament separates the greater and lesser sacs of the right? Gastrohepatic ligament
Which structures are connected by the Gastrocolic ligament? Greater curvatures and transverse colon
Which ligament contains the Gastroepiploic arteries? Gastrocolic ligament
The _________________ ligament connects the Greater curvature to the spleen. Gastrosplenic
Which structures are contained by the Gastrosplenic ligament? Short gastric, left gastroepiploic vessels
Which ligament connects the Spleen to the posterior abdominal wall? Splenorenal ligament
What structures are contained by the Splenorenal ligament? Splenic artery and vein, and tail of pancreas.
What are the 4 layers of the gut wall? 1. Mucosa 2. Submucosa 3. Muscularis externa 4. Serosa
What is the deepest layer of the gut wall? Mucosa
What is the outermost layer of the gut wall? Serosa
Which layer of the gut wall are the Meissner plexuses? Submucosa
Which layer of the gut wall secretes fluid? Submucosa
What nerve plexus are found in the Muscularis externa layer of the gut wall? Myenteric nerve plexus (Auerbach)
Another name for Myenteric nerve plexus? Auerbach plexus
What layer of the gut wall is in charge of Motility? Muscularis externa
What is the name given to the serosa if it is retroperitoneal? Adventitia
If the outermost layer is referred as Adventitia, then it is safe to assume that is indicating? Retroperitoneal structure/space
What is the extent of a possible ulcer in relation to the gut layers? Submucosa, inner or outer muscular layer
How far (deeply) does an erosion extend in relation to gut layers? Mucosa only
Which has a greater degree of extend into the layers of the gut wall, erosions or ulcers? Ulcers
What are the slow waves? Frequencies of basal electrical rhythm
What is the frequency of waves of the Stomach? 3 waves/ minute
How many slow waves per minute are seen in the Duodenum? 12 waves/ minute
Which structure has an approximate 8-9 waves/min? Ileum
Which is the GI structure with the slowest basal electrical rhythm? Stomach (3 waves/min)
What are the three structures that compose the Mucosa layer of the gut wall? Epithelium, Lamina propia, and Muscularis mucosa
Submucosal nerve plexus = Meissner
Which gut layer contains the Inner circular layer? Muscularis
Myenteric nerve plexus = Auerbach
Which is deeper into the gut wall, Auerbachs or Meissner? Meissner
What is the outermost sublayer of the Muscularis externa layer? Outer longitudinal layer
Epithelium of the esophagus? Nonkeratinized stratified squamous epithelium
Is the esophagus epithelium, keratinized or nonkeratinized? Nonkeratinized
Which GI structure has nonkeratinized stratified squamous epithelium? Esophagus
What is the role of the Villi and microvilli of the doudenum? Increase absorptive surface
Where in the GI tract are the Brunner glands found? Duodenum
The doudenum is the location of which particular HCO3- secreting glands? Brunner glands
What are two featured histologic findings in the Duodenum? 1. Brunner glands 2. Crypts of Lieberkühn
HCO3- secreting glands of the duodenal mucosa? Brunner glands
What is contained in the crypts of Lieberkuhn? Stem cells that replace enterocytes/goblet cells and Paneth cells that secrete defensins, lysozyme, and TNF.
Where are the Paneth cells found? Inside the crypts of Lieberkühn of the doudenum
What is secreted by the Paneth cells? Defensins, lysozyme, and TNF
Histological findings/features of the Jejunum 1. Plicae circulates and, 2. crypts of Lieberkühn
Which part of the small intestine are the Peyer patches mostly found? Ileum
What are the Peyer patches? Lymphoid aggregates in lamina propria, and submucosa of the ileum
Which ileal layers contain Peyer patches? Lamina propria and submucosa
What are the 3 key histological findings of the ileum? 1. Peyer patches 2. Plicae circulares 3. Crypts of Lieberkühn
Which digestive tract section/structure is with Crypts of Lieberkuhn but not with villi, and with abundant goblet cells? Colon
Crypts of Lieberkühn are found in: Duodenum, Jejunum, Ileum, and colon
Which part of the digestive tract is abundant with goblet cells? Colon and Ileum
What part of the small intestine has the largest number of Goblet cells? Ileum
Which part of the digestive tract has more Goblet cells, Ileum or Colon? Ileum
At what level does the abdominal aorta starts? T12
What arteries branch off the aorta at T12? - Inferior phrenic - Superior and Middle suprarenal
At which level of the abdominal aorta does the Superior Mesenteric artery branches off? At mid-L1
Which imporatnt artery branches off the abodimian aorta at L3 level? Inferior Mesenteric artery
At what level does the Right and Left common iliac arteries begin? L5
How do arteries that supply GI structures branch off the abdominal aorta? These are single and branch ANTERIORLY
If a artery is single and branches anteriorly form abdominal aorta, it is to supply _______________ structures. Gastrointestinal
Arteries supplying non-GI structures that branch from abdominal aorta. Paired and branch LATERALLY and POSTERIORLY
Which are three main branches of the abdominal aorta that branch off anteriorly? Celiac, SMA, and IMA
Since SMA, IMA, and Celiac arteries branch off anteriorly --> They are single and will supply GI structures
What is the Superior mesenteric syndrome? Condition in which the SMA and aorta compress transverse (third) of doudenum
What is the clinical features of Superior Mesenteric artery syndrome? Intermittent intestinal obstruction symptoms (primarily postprandial)
Malnutrition patient complains of episodic abdominal pain, especially after eating. Dx? Superior Mesenteric artery syndrome
Which areas are most susceptible to colonic ischemia? "Watershed regions"
What are the two "watershed regions" of the colon? 1. Splenic flexure 2. Rectosigmoid junction
What dual blood supply create the Splenic flexure? SMA and IMA
The junction of the SMA and IMA Splenic flexure
What arterial bodies form the Rectosigmoid junction? Last sigmod arterial branch from the IMA and Superior rectal artery
At what point approximately do the Gonadal arteries branch off (laterally) from the abdominal aorta? At the superior part of L2
Which paired vessel branches off the abdominal aorta exactly at the the junction of L1 and L2? Renal arteries
What artery supplies the Foregut? Celiac
What artery supplies the Midgut? SMA
What artery supplies the Hindgut? IMA
Which embryonic gut region(s) are Parasympathetically innervated by the Vagus nerve? Foregut and Midgut
The Hindgut is innervated by the _____________ nerve. Pelvic
Which nerve innervates the Pharynx? Vagus
What are the branches of the Celiac trunk? 1. Common hepatic artery 2. Splenic artery 3. Left Gastric artery
What arterial bodies constitute the main blood supply to of the stomach? The branches of the Celiac trunk
At the Celiac trunk and stomach levels, which are some strong anastomoses that exist? 1. Left and right gastroepiploic 2. Left and right gastrics
What artery is penetrated by posterior duodenal ulcers? Gastroduodenal artery
Which artery is perforated by anterior duodenal ulcers? Anterior abdominal cavity, potentially leading to pneumoperitoneum
Antrum of stomach is mostly irrigated by _________________. Common hepatic artery
Which vessels form the anastomosis in the esophagus? Left gastric <---> Azygos
Caput medusae appears at the region of the _______________. Umbilicus
What arterial and venous bodies create the anastomosis that lead to Caput medusae? Paraumbilical <---> Small epigastric veins the anterior abdominal wall.
Which type of varices are seen in Portal hypertension? Esophageal varices, Caput medusae, and anorectal varices.
What is a common invasive treatment for Portal hypertension? TIPS
TIPS can precipitate _________. Hepatic encephalopathy
What is TIPS? Treatment with a transjugular intrahepatic portosystemic shunt (TIPS) between the portal vein and hepatic vein relieves portal hypertension by shunting blood to the sytemic circuation bypassin the liver.
Where is the Pectinate line? Formed where endoderm (hindgut) meets ectoderm
What is another name for Pectinate? Dentate
Innervation above the pectinate line? Visceral innervation
Arterial supply above the pectinate line? Superior Rectal artery (branch of IMA)
Where does lymph form above the pectinate line drains into? Internal iliac lymph node
What type of hemorrhoids are developed above the pectinate line? Internal hemorrhoids
What type of malignancy is associated with tissue above the pectinate line? Adenocarcinoma
Not painful hemorrhoids Internal hemorrhoids
Non-painful hemorrhoids must be _____________ pectinate line. Above
External hemorrhoids appear ________ the pectinate line. Below
What are some pathologies/malignancies that are seen below the pectinate line? 1. External hemorrhoids 2. Anal fissures 3. Squamous cell carcinoma
Painful hemorrhoids appear ________________ the dentate line. Below
What is an anal fissure? Tear in the anal mucosa below the Pectinate line.
What are associated conditions that accompany anal fissures? Low-fiber diets and constipation
Why do anal fissures tend to appear posteriorly? It is a poorly perfused area
Which type of hemorrhoids receive Somatic innervation? External hemorrhoids
Which artery supplies below the pectinate line? Inferior rectal artery (branch of the Internal Pudendal artery)
Where does lymph below the pectinate line drain to? Superficial inguinal Lymph node
The inferior rectal artery is a branch of the: Internal pudendal artery
Inferior rectal vein --> internal pudendal vein --> internal iliac vein --> Common iliac vein -----> IVC Venous drainage below the pectinate line
Superior rectal vein ---> Inferior mesenteric vein ---> Splenic vein ---> portal vein Venous drainage above the pectinate line
Venous blood below the pectinate line ultimately drains into what major venous body? IVC
Which is the vein that receives venous blood from areas above the pectinate line? Portal vein
Description of liver architecture Hexagonally arranged lobules surrounding the central vein with portal triads on edges .
What are the portal triads in liver architecture, composed of? Portal vein, Hepatic artery, bile ducts, as well lymphatics
Which surface of the hepatocytes faces the canaliculi? Apical surface
The basolateral surface of the hepatocytes faces the ______________________. Sinusoids
What are Kupffer cells? Specialized macrophages of the liver, located ate the sinusoids.
What is the name of liver macrophages? Kupffer cells
Where in the liver architecture are the Kupffer cells located? Sinusoids
What is the abbreviation used for Hepatic stellate cells? Ito
Where are the Hepatic stellate (Ito) cells located? Space of Disse
What do Hepatic stellate cells store? Vitamin A
What do hepatic stellate cells produce when activated? Extracellular matrix
Which cells are responsible for hepatic fibrosis? Ito cells (hepatic stellate cells)
What is the name of the Liver Zone 1? Periportal zone
Which zone of the liver is first affected by viral hepatitis? Zone I
Ingested toxins such as cocaine affect which zone of the liver? Zone I
Name of Zone II of the liver? Intermediate zone
Which is the known pathology to affect zone II of the liver? Yellow fever
Yellow fever will cause liver damage by affecting the Zone _____. II
Different forms to refer to Zone III of the liver? - Pericentral vein zone or, - Centrilobular zone
Which zone of the liver is 1st affected by ischemia? Zone III
Which zone, I, II, or III, has the highest cytochrome P-450 concentration in the liver? Zone III
Which is the site of alcoholic hepatitis? Zone III
Which zone of the liver is the most sensitive to metabolic toxins? Zone III
What are some common metabolic toxins that affect the zone III of liver? Ethanol. CCl4, halothane, and rifampin
Which cells in the liver store vitamin A? Stellate cells in space of Disse
Gallstones that get lodged in the ampulla of Vater cause: - Blockage of both: 1. Common bile duct ----> Cholangitis 2. Pancreatic ducts ----> Pancreatitis
What is the most common type of tumor seen at the head of the pancreas? Ductal adenocarcinoma
What is the Courvoisier sign? Enlarged bladder with painless jaundice
What is a consequence of a tumor at the head of the pancreas? Obstruction of common bile duct ---> enlarged bladder with painless jaundice
How do a cholangiography help to visualize gallbladder problems? Shows filling defects in gallbladder and cystic duct
What is the organization of the femoral region in respect of structures passing through? Arranged for lateral to medial: Nerve-Artery-Vein-Lymphatics
Which is the most lateral structure of the femoral region? Nerve
Mnemonic used to describe the order and organization of structures in the femoral region NAVeL
What structures are contained by the Femoral triangle? Femoral nerve, artery, and vein
What structures are contained by the Femoral sheath? Femoral artery, vein, and canal, but NOT the femoral nerve
Facial tube 3-4 cm below inguinal ligament? Femoral sheath
What is in the canal covered by the Femoral sheath? Deep inguinal lymph nodes
Where is the site of protrusion of a direct inguinal hernia? Abdominal wall
What is the site of protrusion of an indirect inguinal hernia? Deep (internal) inguinal ring
What is a hernia? Protrusion of peritoneum through an opening, usually at site of weakness.
What are two significant concerns or complications of all hernias? 1. Incarceration (not reducible back into abdomen/pelvis) 2. Strangulation( ischemia and necrosis)
When a hernia is said be incarcerated, it means? Hernia cannot be reducible back into the abdomen or pelvis
Complicated hernias present with: Tenderness, erythema, and fever
Abdominal structures enter the thorax. Dx? Diaphragmatic hernia
Which side is more prone to develop a diaphragmatic hernia? Left side due to relative protection of right hemidiaphragm by liver.
Which is the most common type of diaphragmatic hernia? Hiatal hernia
What is a hiatal hernia? Stomach herniates upward through the esophageal hiatus of the diaphragm
Stomach protrudes upward through the diaphragm Hiatal hernia
What are the two most common types of hiatal hernias? 1. Sliding hiatal hernia 2. Paraesophageal hiatal hernia
Gastroesophageal junction is displaced upward as gastric cardia slides into hiatus Sliding hiatal hernia
Which condition is described with "hourglass stomach" Sliding hiatal hernia
Which is the MC type of hiatal hernia? Sliding hiatal hernia
What is a Paraesophageal hiatal hernia? Gastroesophageal junction is usually normal but gastric fundus protudes into thorax.
Which part of the stomach is protruded/herniated upward in a Sliding hiatal hernia? Gastric cardia
Which hiatal hernia has the gastric fundus protrading/herniating upward into the thorax? Paraesophageal hiatal hernia
Which type of inguinal hernia goes THROUGH the internal (deep) inguinal ring? Indirect inguinal hernia
Which inguinal hernia goes into the scrotum? Indirect inguinal hernia
Protrusion of peritoneum goes through the deep inguinal ring --> external inguinal ring, and finally into scrotum. Dx? Indirect inguinal hernia
Anatomically, how does an indirect inguinal hernia enter the internal inguinal ring? Lateral to inferior epigastric vessels
What is the cause of Internal inguinal hernias? Failure of processus vaginalis to close
What is developed in a person that suffered of failure of processus vaginalis to close? Indirect inguinal hernia
Besides an indirect inguinal hernia, what other condition may be developed due to failure of processus vaginalis to close? Hydrocele
Which population is seen with Indirect inguinal hernias most commonly? Infants; especially males
What path is followed by an indirect inguinal hernia? Path of descent of testes; covered by all 3 layers of spermatic fascia.
During a hernia repair, the surgeon notices the hernia is covered by all 3 layer of the spermatic fascia. Dx? Indirect inguinal hernia
What is the featured structure by which a direct inguinal hernia goes through? Hesselbach triangle
Bulges directly through parietal peritoneum medial to the inferior epigastric vessels but lateral to the rectus abdominis. Direct inguinal hernia
Which type of inguinal hernia is only covered by the external spermatic fascia? Direct inguinal hernia
What type of inguinal hernia is mostly seen in older men? Direct inguinal hernia
Weakness in the transversalis fascia leads to the development of: Direct inguinal hernia
Hesselbach triangle is associated with: Direct inguinal hernia
Medial to inferior epigastric vessels ---> Direct inguinal hernia
Lateral to the Inferior Epigastric vessels------> Indirect inguinal hernia
Which population is more affected by Direct inguinal hernia development? Older men
Through which ring does a Direct inguinal hernia passes? External (superficial) inguinal ring only
If the inguinal hernia only passes through one inguinal ring. Dx? Direct inguinal hernia
Femoral hernia pathogenesis: Protrudes below inguinal ligament through femoral canal below and lateral to pubic tubercle
What gender is most commonly affected by Femoral hernias? Female
Which type of hernia, inguinal or femoral, are more prone to present with incarceration or strangulation? Femoral hernia
Which hernia is found to protrude below the inguinal ligament? Femoral hernia
If the hernia is said to be lateral to pubic tubercle. Most likely Dx? Femoral hernia
What are the bordering structures of the Hesselbach triangle? - Inferior Epigastric vessels - Lateral border of rectus abdominis - Inguinal ligament
What is the INFERIOR border of the Hesselbach triangle? Inguinal ligament
What is the MEDIAL border of the Hesselbach triangle? Lateral border of the Rectus abdominis
What is the SUPEROLATERAL border of the Hesselbach triangle? Inferior epigastric vessels
Created by: rakomi
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