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Pathology
FA complete review part 3 Oncogenes and Tumor suppressor genes
| Question | Answer |
|---|---|
| Gene prodcut of ALK | Receptor tyrosine kinase |
| What are the associated neoplasms of ALK? | Lung adenocarcinoma |
| What is the gen product of BCR-ABL? | Tyrosine kinase |
| What are the associated neoplasms of BCR-ABL gene? | CML, ALL |
| CML is due to which gene? | BCR-ABL |
| What is the associated neoplasm of BCL-2? | Follicular and diffuse large B cell lymphomas |
| What is the associated gene product of Follicular and diffuse large B cell lymphoma? | Antiapoptotic molecule |
| What is the gene product of Bcl-2? | Antiapoptotic molecule |
| What is the role or function of antiapoptotic molecule? | Inhibits apoptosis |
| What gene is associated with Diffuse large B cell lymphoma? | Bcl-2 |
| Gain of function mutation converts proto-oncogene to oncogene. | Oncogene function |
| Need damage to only one allele | Oncogene |
| What is the gene product of BRAF? | Serine/threonine kinase |
| What are the associated neoplasms of gene BRAF? | Melanoma, non-Hodgkin lymphoma, papillary thryroid carcinoma |
| GIST associated gene? | c-KIT |
| What is the gene product of c-KIT? | Cytokine receptor |
| Cytokine receptor is the gene prodcut of which gene? | c-KIT |
| What is the associated gene of Gastrointestinal stromal tumor? | c-KIT |
| c-MYC produce asn ___________________ (gene product). | Transcription factor |
| What is the associated neoplasm of c-MYC? | Burkitt lymphoma |
| Burkitt lymphoma is due to a _____________ produced by c-MYC. | Transcription factor |
| What is the HER2/neu (c-erbB2) gene product? | Receptor tyrosine kinase |
| Which genes have Receptor tyrosine kinase as gene product? | RET, HER2/neu , and ALK. |
| Associated neoplasm of JAK2 gene? | Chronic myeloproliferative disorders |
| What cancers are associated with gen KRAS? | Colon, lung, and pancreatic cancers |
| Which transcription factor (gene) is associated with Lung tumor? | MYCL1 |
| N-myc gene makes a transcription factor and is associated with __________________. | Neuroblastoma |
| RET gene is involved in which neoplasms? | MEN 2A and 2B, and papillary thyroid carcinoma |
| Loss of function refers to tumor suppressor or oncogenes? | Tumor suppressor genes |
| Both alleles of need to mutated for expressivity of disease | Tumor suppressor gene |
| APC is a ____________________________ gene. | Tumor suppressor |
| What is the associated condition of APC (gene)? | Colorectal cancer |
| How does APC cause colorectal cancer? | Negative regulator of B-catenin/WNT pathway |
| Which are two common DNA repair proteins associated with Breast, ovarian, and pancreatic cancer? | BRCA1/BRCA2 |
| What are the associated neoplasms of CDKN2A? | Melanoma and Pancreatic cancer |
| Colon cancer is associated with which tumor suppressor gene? | DCC |
| Gene APC refests to _______________________ cancer, and DCC is associated with ______________ cancer. | APC ----> colorectal DCC ------> colon |
| Deleted in Colon Cancer | DCC |
| Deleted n Pancreatic Cancer | DCP |
| DCP is the gene product of which specific gene? | SMAD4 (DPC4) |
| Gene product of MEN1? | Menin |
| Gene product of NF2? | Merlin (schwannomin) protein |
| Ras GTPase activating protein | Neurofibromin |
| What is the role PTEN? | Negatively regulates PI3K/AKT pathway |
| What are the associated neoplasm of PTEN? | Breast, Prostate, and endometrial cancer |
| What is the product or function of Rb? | Inhibits EF2; Blocks G1 ---> S phase transition |
| Retinoblastoma and Osteosarcoma are both associated with ____, a tumor suppressor gene. | Rb |
| Which are the most important Rb-associated neoplasms? | Retinoblastoma and Osteosarcoma |
| What is the role of TP53 gene? | Its gene product is p53, which activates p21, and blocks G1 --S phase transition. |
| What tumor suppressor gene is often affected in most human cancers? | TP53 |
| What syndrome is due to mutated TP53 tumor suppressor gene? | Li-Fraumeni syndrome |
| What malignancies are associated with Li-Fraumeni syndrome? | Sarcoma, Breast, Leukemia, and adrenal gland |
| SBLA is another way to refer to: | Li-Fraumeni syndrome |
| What is the the associated tumor suppressor gene and gene product of Tuberous sclerosis? | TSC1; Hamartin protein |
| What are the two associated proteins in the development of Tuberous sclerosis? | Tuberin and Hamartin proteins |
| What is the role of VHL? | Inhibits hypoxia inducible factor 1a |
| What condition is associated with VHL? | von Hippel-Lindau disease |
| Mutated tumor suppressor gene WT1 causes --> | Wilms tumor (nephroblastoma) |
| What is the role of WT1 gene? | Transcription factor that regulates urogenital development |
Created by:
rakomi
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