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Microbiology

FA complete review part 3 Mycoses and Parasites

QuestionAnswer
Systemic mycoses, all this can cause: Pneumonia and can disseminate
All mycoses are: Dimorphic fungi
Which is the only systemic mycoses that is not eyats at 37 Celcius? Coccidioides
Systemic mycoses are ________________ at 20 C. Mold
At 37 C, all systemic mycoses are in _____________ form. Yeast
What is a common characteristic between systemic mycoses and TB? Can form granules
What i the treatment for local infections of systemic mycoses? Fluconazole or Itraconazole
Disseminated infection of a systemic mycoses is treated with: Amphotericin B
What is the Endemic location of Histoplasmosis? Mississippi and Ohio River Valleys
What is the pathologic features of Histoplasmosis? Macrophage is filled with Histoplasma
Which systemic mycose is smaller than RBC? Histoplasma
Histoplasma is often associated with: Bird or bat droppings
What are the unique clinical signs of Histoplasmosis? Palatal/ tongue ulcers, and splenomegaly
Person with oral ulcer. Which is the most likely responsible systemic mycoses? Histoplasma
What is nte endemic region of Blastomycosis cases? Eastern and Central United States
Broad-based budding of Blastomyces Pathologic features of Blastomycosis
What are the unique signs of Blastomycosis? Inflammatory lung disease, can disseminate to skin/bone. Verrucous skin lesions can stimulate SCC Forms granulomatous nodules
What systemic mycoses is same size as RBC? Blastomyces
Endemic region of Coccidioidomycosis? Southwestern US, and California
Pathologic features of Coccidioidomycosis? Spherule filled with endospores of Coccidioides
Endospores association with which systemic mycosis? Coccidioidomycosis
Coccidioides is ________________________ than an RBC. Much larger
"Captain's wheel" Paracoccidioidomycosis
Latin America Is the endemic region for cases of whcat type f systemic mycosis? Paracoccidioidomycosis
Paracoccidioidomycosis is more ofnen in ___________ than _______. Males >>> Females
Which two systemic mycoses are much larger than an RBC? Paracoccidioides and Coccidioides
What are the most common dermatophytes? Microsporum, Trichophyton, and Epidermophyton
Branching hyphae visible on KOH preparation with blue fungal stain. Associated with pruritus. Dermatophytes
What area of the body is Tinea capitis referred to? Head and scalp
What are the associated conditions or symptoms of Tinea capitis? Lymphadenopathy, alopecia, and scaling.
Tinea corporis occurs on the _______________. Torso
What are some characteristics by Tinea corporis? Erythematous scaling ringins ("ringworm") and central clearing
What type of Tinea occurs in the inguinal area? Tinea cruris
What are the varieties of Tinea pedis? 1. Interdigital 2. Moccasin distribution 3. Vesicular type
Associated to Tinea ungutum? Onychomycosis; occurs on nails
Which cutaneous mycoses occurs in the nails? Tinea ungutum
What causes Tinea (Pityriasis) versicolor? Malassezia spp
"Spaghetti and meatballs" appearance on microscopy. TInea (pityriasis) versicolor
What is the MC treatment of Tinea versicolor? Selenium sulfide, topical and/or oral antifungal medications
List of Opportunistic fungal infections: 1. Candida albicans 2. Aspergillus fumigatus 3. Cryptococcus neoformans 4. Mucor and Rhizopus spp. 5. Pneumocystis jirovecii 6. Sporothrix schenckii
alba = white
Which opportunistic fungal infection forms a pseudohyphae and budding yeast at 20 C , germ tus at 37 C. Candida albicans
A candida albicans in immunocompromised usually causes: Oral and Esophageal thrush
What type of patients get a vulvovaginitis by c. albicans infection? Diabetics and those with of antibiotics
What condition/patients have increased risk of disseminated candidiasis? Neutropenic patients
What are some pathologic associations with c. albicans? - Oral and Esophageal thrush - Vulvovaginitis - Diaper rash - Endocarditis (IV drug users) - Disseminated candidiasis - Chronic mucocutaneous candidiasis
WHat is the most treatment for vaginal c. .albicans infections? Oral fluconazole/topical azole
Oral/esophageal thrush candidiasis is treated with: Nystatin, fluconazole, or echinocandins
Systemic disseminated candidiasis is treated with: Fluconazole, echinocandins, and amphotericin B
Monomorphic septate hyphae that branch at 45 Acute angle. Aspergillus fumigatus
Invasive aspergillosis in immunocompromised causes: Neutrophil dysfunction
What is the associated risk of Aspergillus fumigatus infection in those with TB history? Aspergillosis in pre-existing lung cavities
What is produced by Aspergillus fumigatus that is associated with development of Hepatocellular carcinoma? Aflatoxins
WHat is ABPA? Allergic bronchopulmonary aspergillosis
What is the pathogenesis of ABPA? Hypersensitivity response associated with asthma and cystic fibrosis; may cause bronchiectasis and eosinophilia.
45 degree angle sepate? Aspergillus fumigatus
Aflatoxins are associated with which opportunistic fungus? Aspergillus fumigatus
Fungal opportunistic infection with narrow budding? Cryptococcus neoformans
Narrow budding, heavy encapsulated yeast, not dimorphic, and found in soil and pigeon droppings? Cryptococcus neoformans
How is Cryptococcus neoformans mostly found? In soil and bird droppings
C. neoformans travels via the blood system into the ____________. Meninges
What agar is used to culture C. neoformans? Sabouraud agar
Which opportunistic fungus is highlighted with India ink, creating a clear halo? Cryptococcus neoformans
What are pathologies caused by Cryptococcus neoformans infection? 1. Cryptococcosis 2. Cryptococcal meningitis 3. Cryptococcal encephalitis
"Soap bubbles" in the brain of an AIDS patient? Cryptococcus neoformans infection
What is the treatment for Cryptococcal meningitis? Amphotericin B + Flucytosine
Description of Mucor and Rhizopus spp. Irregular, broad, nonseptate hyphae branching at wide angles
Ir septate is at wide angles, which is the most common opportunistic fungal infection reference? Mucor and Rhizopus spp
Acute angle branching of septate is seen with______________ opportunistic fungal infection. Aspergillus fumigatus
What is the most common pathology caused by Mucor and Rhizopus spp infection? Mucormycosis
What patients are at increased risk of Mucormycosis? Ketoacidotic diabetic and/or neutropenic patients
After Mucor and Rhizopus species proliferate in the blood vessel walls, what is the course of the infection followed by? Penetrate Cribriform plate and then enter the brain.
Areas affected by CNS mucor and rhizopus infection? Rhinocerebral, frontal lobe abscess Cavernous sinus thrombosis
What are clinical signs of Mucor and Rhizopus infection? Headache, facial pain, black necrotic eschar on face, with or without cranial nerve involvement.
Black necrotic eschar in face is most commonly associated with which opportunistic fungal infection? Mucor and Rhizopus spp infection
What is the indicated treatment for Mucor and Rhizopus spp infection? Surgical debridement and then amphotericin B or isavuconazole
What is the abbreviation for Pneumocystis jiroveci pneumonia? PCP
What is PCP? Pneumocystis pneumonia, a diffuse interstitial pneumonia, caused by Pneumocystis jirovecii.
What is CRX/CT description of PCP? Diffuse, BILATERAL ground-glass, opacities, with pneumatoceles.
Disc-shaped yeast seen in methenamine silver stain of lung tissue. Dx? PCP
What is the treatment for PCP? TMP-SMX, pentamidine, dapsone (prophylaxis only), and atovaquone.
What is the drug used for PCP prophylaxis? Dapsone
Prophylaxis treatment in AIDS patient for PCP starts when CD4+ T cell count drops below: 200 cells/mm3
What fungal organism causes Sporotrichosis? Sporothrix schenckii
What is the description of Sporothrix schenckii? Dimorphic, cigar-shaped budding yeast that grows in branching hyphae with rosettes of conidia;
Which fungal organism lives in vegetation? Sporothrix schenckii
What disease is due to trauma (break of skin) by a thorn with S. schenckii? Rose gardener's disease
What is the treatment for Rose Gardener's disease? Itraconazole or Potassium iodide
S. schenckii infection is drains along with lymphatics causing? Ascending lymphangitis
Most common Protozoal GI infectious organisms are: Giardia lamblia, Entamoeba histolytica, and Cryptosporidium
What disease is caused by Giardia lamblia? Giardiasis
What is Giardiasis? Infection with Giardia lamblia; bloating, flatulence, foul-smelling, fatty diarrhea
Which type of people are often at higher risk of Giardiasis? Campers and/or hikers
What is the treatment for Giardia lamblia infection? Metronidazole
How is the diagnosis of Giardiasis made? Multinucleated trophozoites or cysts in stool, antigen detection
Oocysts in water. Transmission of? Cryptosporidium
What is the mode of transmission of Giardia lamblia and Entamoeba histolytica? Cysts in water
What disease is due to Entamoeba histolytica infection? Amebiasis
What is the clinical presentation of Amebiasis? Bloody diarrhea (dysentery), liver abscess ("anchovy paste" exudate), RUQ pain
What is the histology of Entamoeba histolytica? Colon biopsy shows flask-shaped ulcers
What is the treatment of Entamoeba histolytica and Giardia lamblia? Metronidazole
Severe diarrhea in AIDS due to Protozoal GI infection? Cryptosporidium
Diagnosis of Cryptosporidium Oocysts on acid-fast stain , antigen detection
Cysts with up to 4 nuclei in stool. Dx? Entamoeba histolytica
Trophozoites with engulfed RBCs in the cytoplasm? Entamoeba histolytica
What is the treatment for Cryptosporidium for healthy individuals? Nitazoxanide
Filtering city water supplies is a mode of prevention of what organism infection? Cryptosporidium
Protozoa-- CNS infection list: 1. Toxoplasma gondii 2. Naegleria fowleri 3. Trypanosoma brucei
Mode of transmission of Toxoplasma gondii 1. Cysts in meat (most common); 2. Oocysts in cat feces
Why do pregnant women should avoid contact with cat feces? May be contaminated with Toxoplasma gondii oocysts which can cross the placenta
What is congenital toxoplamois presented? Triad of: 1. Chorioretinitis 2. Hydrocephalus 3. Intracranial calcifications
Tachyzoite, often seen to diagnose infection with: Toxoplasma gondii
What is the treatment for Toxoplasma gondii infection? Sulfadiazine + Pyrimethamine
Sulfadiazine co administer with Pyrimethamine. Most likely infection? Toxoplasmosis
Brain abscesses; seen as multiple enhancing ring lesions on MRI. Dx? Toxoplasmosis
What are the labs seen by Toxoplasma infection to a immunocompetent individual? 1. Mononucleosis-like symptoms 2. (-) heterophile antibody test
Rapidly fatal meningoencephalitis is caused by an infection with: Naegleria fowleri
Amoebas in CSF is diagnostic for infection with: Naegleria fowleri
Where is the typical place/area for a possible Naegleria fowleri infection? Swimming in warm freshwater
What is "freshwater"? Water from rivers, lakes, reservoirs, underground streams, and other sources.
Infection with Trypanosoma brucei causes which disease? African sleeping sickness
What organism causes African sleeping sickness? Trypanosoma brucei
What is "African sleeping sickness"? Enlarged lymph nodes, recurring fever, somnolence, and coma due to T. brucei infection
Reason for recurring fever in African sleeping sickness? Due to antigenic variation
What is the transmission mode of Trypanosoma brucei? Tsetse fly, a painful bit
How is the diagnosis for Trypanosoma brucei infection made? Trypomastigote in blood smear
What is the treatment for blood-borne Trypanosoma brucei infection? Suramin
Melarsoprol is used for: Treatment of Trypanosoma brucei infection for CNS penetration
What are the main two protozoa that cause hematological infections? Plasmodium (species) and Babesia
What is the most common disease caused by Plasmodium infection? Malaria
What are the main clinical signs of Malaria? Fever, headache, anemia, and splenoagay
Which type of Plasmodium specie causes a 48-hr cycle of fever? P. vivax/ovale
Which plasmodium type causes a tertian cycle? Pl vivax/ovale
What does a tertian cycle of fever by P. vivax/ovale means? Fever on first day and third day, thus been 48 hours apart from each other
WHat is the form name of the dorman P. vivax/ovale in the liver? Hypnozoite
P. falciparum cause an__________ fever pattern. Irregular
Which plasmodium causes a quatrain or (72-hr) fever cycle or pattern> P. malariae
What is the mode of transmission of the Plamodium? Anopheles mosquito
Anopheles mosquito transmits what organism? Plasmodium spps
What medication is used for sensitive Plasmodium infection? Chloroquine
What is the MOA of chloroquine? Blocks Plasmodium heme polymerase
Which Plasmodium enzyme is blocked by Chloroquine? Heme polymerase
In case of Plasmodium been resistant to Chloroquine, what is an alternative treatment option? Mefloquine or atovaquone/proguanil
What test should be done to patients about to be treated with IV quinidine or artesunate? Test for G6PD deficiency
When should IV quinidine or Artesunate should be used? In life-threatening situations only, and hth previous test for G6PD deficiency.
What treatment is added to P. vivax/ovale infecton? Primaquine for hypnozoite
What drug is used to treat Hypnozoite found in liver of patient with a P. vivax/ ovale infection? Primaquine
What organism causes Babesiosis? Babesia
What is the presentation of Babesiosis? Fever and hemolytic anemia; predominantly Northeastern United States
MOde of transmission Babesi? Ixodes tick
Blodo semar shows: ring form, "Maltese cross". Dx? Babesiosis
What is the characteristic finding of Babbeiosis in order to make dx? "Maltese cross" in blood smear
Treatment of Babesia infection Atovaquone + azithromycin
Ixodes tick carries which two organisms? Babesia and Borrelia burgdorferi
Babesiosis and Lyme disease share the same ___________________. Ixodes tick
What are some common findings in Blood smear of Plasmodium sp? 1. Trophozoite ring form within RBC 2. Schizont containing merozoites 3. Red granules throughtout RBC in P. vivax/ovale
What are Schuffner stippling? Red granules found in Blood smear of Plasmodium infection.
Common protozoan visceral infectious organisms: Trypanosoma cruzi and Leishmania donovani
What disease is caused by T. cruzi infection? Chagas disease
What are some symptoms and signs of Chagas disease? 1. Dilated cardiomyopathy with apical atrophy 2. Megacolon 3. Megaesophagus 4. (+) Romana sign
Big heart, big esophagus, and big colon. Dx? Chagas disease
What is the endemic region for Chagas disease? South America
What is the Romana sign? Unilateral periorbital swelling
(+) Romana sign. Dx. Chagas disease
"Kissing" bug causes Chagas disease
THe kissing bug is a type of ______________ bug, which carries ___________________, causing __________________ diseases. Reduviid bug; Trypanosoma cruzi ; Chagas disease
What is the common treatment for Chagas disease caused by T. cruzy? Benznidazole or Nifurtimox
Patient on Nifurtimox. Dx? Chagas disease
Suspect Chagas disease or T. cruzi infection in a person that: 1. Traveled recently to South America (Brazon MC) 2. Shows enlarged heart (DCM) 3. Complains of unilaerl eye swelling
The Sandfly transmit: Leishmania donovani
What two pathologies are due to Leishmania donovani infection? 1. Visceral leishmaniasis 2. Cutaneous leishmaniasis
Waht is hantoher name for Visceral leshimanisis? Kala-azar
What is the clinical presentation of Kala-azar? Spiking fevers, hepatosplenomegaly, and pancytopenia
What is the treatment for Leishmania donovani infection? Amphotericin B, and sodium stibogluconate
Macrophages containing amastigotes. Dx? Leishmania donovani infection
What is the most common sexually transmitted protozoan infection? Vaginitis due to Trichomonas vaginalis infection
What is Trichomonas vaginalis? Sexually transmitted protozoan
Clinical profile of Trichomonas vaginalis vaginitis? Foul-smelling, greenish discharge; itching and burning;
How is Trichomonas vaginal s infection diagnosed? Motile trophozoites on wet mount; "strawberry cervix"
The term "strawberry cervix" most likely indicate: Trichomonas vaginalis infection
What the treatment for patient and partner with Trichomonas vaginalis infection? Metronidazole
Which is nematodes are ingested? Enterobius, Ascaris, Toxocara, Trichinella, and Trichuris
Which nematodes enter body via cutaneous? Strongyloides, Ancylostoma, and Necator
Which nematodes are acquired through a bite? Loa Loa, Onchocerca volvulus, and Wuchereria bancrofti
Common name for nematodes Roundworms
What is the common name for Enterobius vermicularis? Pinworm
What disease is caused by Enterobius vermicularis? Anal pruritus
How is anal pruritus caused by E. vermicularis diagnosed? By the tape test
What is the treatment of Enterobius vermicularis infection? Pyrantel pamoate or Bendazoles
Giant roundworm scientific name is: Ascaris lumbricoides
What is the common name for Ascaris lumbricoides? Giant roundworm
What disease is caused by Ascaris lumbricoides? 1. Obstruction of ileocecal valve, 2. Biliary obstruction 3. Intestinal perforation
From where does Ascaris lumbricoides migrate? Nose/mouth
What is the best treatment option for Ascaris lumbricoides? Bendazoles
Threahewromd = Strongyloides stercolaris
Larva in soil penetrate skin; rhabditiform larva seen under microscope. Strongyloides stercolaris
Autoinfection is most likely seen with which roundworm infection? Strongyloides stercolaris
What is the treatment for Strongyloides stercoralis infection;? Ivermectin or bendazoles
How does Ancylostoma duodenale, Necator americanus cause anemia? Sicking bloood form interinal (duodena) wall
Cutaneous larva migrans is due to what infection? Ansylostoma doudenale, na ENcator Amricansis infcherion
Pruritic, serpiginous rash from walking barefoot on contaminated beach Cutaneous larva migrans
In which tissue does trichinella spiralis takes home when it penetrates the host? Striated muscle
Which disease is caused by Trichinella spiralis infection? Trichinosis
Trichinella and Trichuris are both treated with _________________. Bendalzoles
Whipworm is known as: Trichuris trichiura
Hookworms are: Ancylostoma duodenale and Necator americanus
List of Intestinal Nematodes 1. Enterobius vermicularis 2. Ascaris lumbricoides 3. Strogyloides stercolaris 4. Ancylostoma duodenale, Necator americanus 5. Trichinella spiralis 6. Trichuris trichiura
A list of Tissue nematodes 1. Toxocara canis 2. Onchocerca volvulus 3. Loa loa 4. Wuchereria bancrofti
What condition is due to Toxocara canis infection? Visceral larva migrans
What causes Visceral larva migrans? Toxocara canis infection
What important effects of Visceral larva migrans? Myocarditis, liver damage, and eye damage (visual impairment, and blindness), and CNS symptoms (seizures, coma)
What is the best treatment for Toxocara canis? Bendazoles
What are clinical features of Onchocerca volvulus infection? Skin changes, loss of elastic fibers, and river blindness
Black flies, black skin nodules, "black sight" is a mnemonic to describe what infection? Onchocerca volvulus
What is the treatment for Onchocerca volvulus? Ivermectin
The clue "river blindness" refers to _________________________ infection. Onchocerca volvulus
What organism is transmitted by the Female Backfly? Onchocerca volvulus
What two tissues are affected mainly by Loa loa? 1. Swelling of the skin 2. Worm in conjunctivitis
Which flies transmit Loa loa? Deer, horse, and mango flies
What is the best treatment option for Loa loa and Wuchereria bancrofti? Diethylcarbamazine
Diethylcarbamazine is used to treat which tissue nematodes? Loa loa and Wuchereria bancrofti
What condition is commonly caused by Wuchereria bancrofti? Lymphatic filariasis (elefantiasis)
What is the common name of the condition caused by W. bancrofti? Elephantiasis
Describe the cause of lymphedema in Elephantiasis? Wuchereria bancrofti organisms (worms) invade the lymph nodes leading to inflammation and subsequent lymphedema
How long after initial infection does Elephantiasis present clinically? After 9 months to a 1 year.
What is the vector for Wuchereria bancrofti? Female mosquito
Female backfly -----> Female mosquito ------> Onchocerca volvulus Wuchereria bancrofti
Common name for cestodes Tapeworms
Which are the most relevant cestodes? 1. Taenia solium 2. Diphyllobothrium latum 3. Echinococcus granulosus
Treatment for Taenia solium? Praziquantel
Which is the mode of transmission bo the T. solium? 1. Ingestion of larvae encysted in undercooked pork (intestinal tapeworm) 2. Ingestion of eggs in food contaminated with human feces
What conditions are related to the acquisition of T. solium by ingestion of eggs in contaminated food? Cysticercosis, neurocysticercosis
What is the specific treatment option for Neurocysticercosis? Albendazole
What is neurocysticercosis? CNS infection with T. solium due to ingestion of eggs in human feces contaminated food
What are the CNS symptoms seen with Neurocysticercosis? Cystic CNS lesions and seizures
What disease is due to Diphyllobothrium latum infection? Megaloblastic anemia due to Vitamin B12 deficiency.
Why does D. latum infection causes a Vitamin B12 deficiency? Tapeworm competes for B12 in intestine --> megaloblastic anemia
What is the MC mode of transmission of Diphyllobothrium latum? Ingestion of larvae in raw freshwater fish
Which tapeworms are treated with Praziquantel? Diphyllobothrium latum and Taenia solium
What conditions are associated with Echinococcus granulosus infection? 1. Hydatid cysts ("eggshell calcification") in liver 2. Cyst rupture can cause anaphylaxis
Why are E. granulosus cysts handled with extreme care during surgery? Rupture can cause anaphylaxis
What animal is the intermediate host for Echinococcus granulosus? Sheep
What is the MC mode of transmission of E. granulosus? Ingestion of eggs in food contaminated with dog feces
Another name for flukes? Trematodes
What are the most common Flukes? 1. Schistosoma 2. Clonorchis sinensis
What organism is associated by ingestion of undercooked fish? Clonorchis sinensis
What is the treatment option for all trematodes? Praziquantel
Snails are the intermediate host for ____________________. Schistosoma
What are common actions that predispose Schistosoma infections? Swimming or bathing in contaminated fresh water
What are the two most referred subspecies of Schistosoma? S. mansoni and S. haematobium
What is caused by S. mansoni? Liver and spleen enlargement, fibrosis, inflammation , and portal hypertension
What are the two most significant symptoms of Schistosoma mansoni infection? Portal hypertension and Hepatosplenomegaly
What Schistosoma spp is associated with development of Squamous cell carcinomas of the bladder? S. haematobium
Painless hematuria may be a sign of: Squamous cell carcinoma of the bladder due to chronic S. haematobium infection.
What type of hypertension is associated with S. haematobium infection? Pulmonary hypertension
Scabies are due to __________________________ infection. Sarcoptes scabiei
Describe Scabies? Pruritus and serpinginous burrows in webspace of hands and feet.
What areas of the body are classically seen with serpiginous burrows in Scabies? Hands and feet
What are treatment options for Scabies? 1. Permethrin cream 2. Washing/drying all clothing/bedding
What are common Ectoparasites? Sarcoptes scabiei and Pediculus humanus/ Phthirus pubis
What are Pediculus humanus/ Phthirus pubis? Blood-sucking lice that cause intense pruritus with associated excoriations, commonly on scalp and neck or waistband and axilla.
Epidemic typhus is caused by: Rickettsia prowazekii
Trench fever is caused by: Bartonella quintana
What is the common treatment for Pediculus humanus/ Phthirus pubis? Pyrethroids, malathion, or ivermectin lotion, and nit combing.
What parasite is associated with Biliary tract disease and cholangiocarcinoma? Clonorchis sinensis
Brain cysts, seizures are associated with: Taenia solium (neurocysticercosis)
Hematuria, squamous cell bladder cancer is seen with: Schistosoma haematobium
What is the the most common associates of Echinococcus granulosus? Liver (hydatid) cystss
Microcytic anemia can be caused by: Ancylostoma, Necator
What type of anemia is seen with Ancylostoma, Necator? Microcytic anemia
What are common associations (symptoms) of Trichinella spiralis? Myalgias, periorbital edema
Swelling around the eye is often associated with which parasite? Trichinella spiralis
What is the organism responsible for Perianal pruritus? Enterobius
Enterobius causes: Perianal disease
Portal hypertension is caused by: Schistosoma mansoni and Schistosoma japonicum
Vitamin B12 deficiency is seen with: Diphyllobothrium latum
What parasite can cause a megaloblastic anemia? Diphyllobothrium latum
Created by: rakomi
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