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General pharmacology

Drugs metabolising through acetylation CHIPPS Clonazepam Hydralazine Isoniazid PAS Procainamide Sulfonamide
Auto inducible drugs - drugs that activate enzymes that induce their own metabolism Carbamazepine Cyclophosphamide Protease inhibitors except ritonavir
Type A adverse drug reactions - predictable due to known properties of drug Coffee ground emesis - gastritis -NSAID naproxen (inhibits Cox enzymes usually produce PG, prostacyclin, thromboxane. Involved in mediating inflammation, also platelet aggregation, pg dep gi mucosal protection) Nephrotoxicity due to aminnoglycosides
Type B Exaggerated sensitivity Tinnitus after single dose of aspirin
Type B Idiosyncratic Unpredictable reaction in certain patients Non immune hemolytic anemia with primaquine in G6PD deficiency
Type B Immunologic (drug allergy) Rapid urticaria type 1 Drug induced hemolysis type 2 Serum sickness type 3 Contact dermatitis type 4
Potency Amount of drug required to produce a given effect Higher affinity - higher potency
Efficacy Maximum effect that can be produced by a drug
Created by: Akhitha reddy



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