click below
click below
Normal Size Small Size show me how
General pharmacology
Question | Answer |
---|---|
Drugs metabolising through acetylation | CHIPPS Clonazepam Hydralazine Isoniazid PAS Procainamide Sulfonamide |
Auto inducible drugs - drugs that activate enzymes that induce their own metabolism | Carbamazepine Cyclophosphamide Protease inhibitors except ritonavir |
Type A adverse drug reactions - predictable due to known properties of drug | Coffee ground emesis - gastritis -NSAID naproxen (inhibits Cox enzymes usually produce PG, prostacyclin, thromboxane. Involved in mediating inflammation, also platelet aggregation, pg dep gi mucosal protection) Nephrotoxicity due to aminnoglycosides |
Type B Exaggerated sensitivity | Tinnitus after single dose of aspirin |
Type B Idiosyncratic Unpredictable reaction in certain patients | Non immune hemolytic anemia with primaquine in G6PD deficiency |
Type B Immunologic (drug allergy) | Rapid urticaria type 1 Drug induced hemolysis type 2 Serum sickness type 3 Contact dermatitis type 4 |
Potency | Amount of drug required to produce a given effect Higher affinity - higher potency |
Efficacy | Maximum effect that can be produced by a drug |