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Sympathomimetics

DrugMoaUses
Epinephrine and dopamine Alpha and beta 1,2 DA shock with renal failure
Isoproterenol Beta 1 =2 Increase HR and contractility
Dobutamine Beta1>2 Increase HR and contractility Cardiogenic shock (massive MI , hypotension)
NE Alpha >beta 1 > beta 2 Vasoconstriction Septic shock (pneumonia, hypotension)
Phenyephrine Only alpha Vasoconstriction Septic shock DOC in Refraction testing in elderly Nasal decongestant
Pseudoephedrine Acts via alpha Nasal decongestant
Albuterol, salmeterol Beta 2 >beta1 Asthma COPD
Terbutaline, retodrine Beta2 > beta 1 Only beta 2 in retodrine Broncho constriction
Adrenaline Only beta 1 Anaphylactic shock V fibrillation and asystole Brittle asthma when Rx with terbutaline fails Local application - control bleeding - tonsillar bed
Clonidine Alpha 2 agonist HTN S/E sedation,rebound HTN
Methyl dopa Alpha2 agonist HTN DOC in pregnancy S/E hemolytic anemia, sedation
Apraclonidine Alpha 2 + weak alpha 1 Glaucoma (lowers IOP)
Amhetamine Blocks NE reuptake and promotes NE release (indirect agonist) Stimulant - narcolepsy Obesity ADHD
Ephedrine promotes NE release (indirect agonist) Nasal decongestant Urinary incontinence Vasopressor of choice in pregnancy
Cocaine Blocks NE reuptake (indirect agonist) Vasoconstrictor Used as local anesthetic (sodium channel blocker in nerves)
Cocaine intoxication - HTN , tachycardia, chest pain Massive alpha and beta stimulation Rx - benzodiazepines
Created by: Akhitha reddy
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