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FA Review
First Aid Rapid Review
| Question | Answer |
|---|---|
| Abdominal pain, ascites, hepatomegaly | Budd-Chiari syndrome (Post-Hepatic venous thrombosis) |
| Abdominal pain, diarrhea, leukocytosis, recent antibiotic use | Clostridium difficile infection |
| Achilles tendon xanthoma | Familial Hypercholesterolemia |
| Decreased LDL receptor signaling | Familial Hypercholesterolemia |
| Adrenal hemorrhage, hypotension, DIC | Waterhouse-Friderichsen syndrome |
| Meningococcemia | Waterhouse-Friderichsen syndrome |
| Anaphylaxis following blood transfusion | IgA deficiency |
| Anterior "drawer sign" positive | Anterior cruciate ligament (ACL) injury |
| Arachnodactyly, lens dislocation (upward), aortic dissection, hyperflexible joints | Marfan syndrome |
| Fibrillin defect | Marfan syndrome |
| Athlete with polycythemia | Secondary to EPO injection |
| Back pain, fever, night sweats | Pott disease |
| Vertebral TB | Pott disease |
| Bilateral acoustic schwannomas | Neurofibromatosis type 2 |
| Bilateral hilar adenopathy, uveitis | Sarcoidosis |
| What kind of granulomas are seen in Sarcoidosis? | Non-caseating granulomas |
| Black eschar on face of patient with diabetic ketoacidosis | Mucor or Rhizopus fungal infection |
| Blue sclerae | Osteogenesis imperfecta |
| Type I collagen defect | Osteogenesis imperfecta |
| Bluish line on gingiva | Burton line |
| Lead poisoning is seen with which kind of gingival problem? | Burton line |
| Bone pain, bone enlargement, arthritis | Paget disease of bone |
| Increased osteoblastic and osteoclastic activity | Paget disease of bone |
| Bounding pulses, wide pulse pressure, diastolic heart murmur, head bobbing | Aortic regurgitation |
| "Butterfly" facial rash and Raynaud phenomenon in a young female | Systemic Lupus Erythematosus (SLE) |
| Cafe-au-lait spots, Lisch nodules (iris hamartoma), cutaneous neurofibromas, pheochromocytomas, optic gliomas | Neurofibromatosis type 1 |
| Cafe-au-lait spots (unilateral), polyostotic fibrous dysplasia, precocious puberty, multiple endocrine abnormalities | McCune-Albright syndrome |
| Mosaic G-protein signaling mutation is seen with? | McCune-Albright syndrome |
| Calf pseudohypertrophy | Muscular dystrophy |
| What is the most common muscular dystrophy? | Duchenne muscular dystrophy |
| What is Duchenne Muscular dystrophy caused by? | X-linked recessive frameshift mutation of dystrophin gene |
| Cervical lymphadenopathy, desquamating rash, coronary aneurysms, red conjunctiva and tongue, hand-foot changes | Kawasaki disease |
| What is the treatment for Kawasaki disease? | IVIG and aspirin |
| "Cherry-red spots" on macula | Tay-Sachs, Niemann-Pick, central retinal artery occlusion |
| Ganglioside accumulation | Tay-Sachs |
| Sphingomyelin accumulation | Niemann-Pick |
| Chest pain on exertion | Angina |
| Stable Angina: | Chest pain with moderate exertion |
| Chest pain with minimal exertion or at rest | Unstable angina |
| Chest pain, pericardial effusion/friction rub, persistent fever following MI | Dressler syndrome |
| Autoimmune-mediated post-MI fibrinous pericarditis, 2 weeks to several months after acute episode | Dressler syndrome |
| Chest pain with ST depression on EKG | Unstable angina or NSTEMI |
| Chest pain with ST depression on EKG , positive troponins | NSTEMI |
| Chest pain with ST depression on EKG, negative troponins | Unstable angina |
| Child uses arms to stand up from squat | Duchenne muscular dystrophy |
| Positive Gowers sign | Duchenne muscular dystrophy |
| Child with fever later develops red rash on face that spreads to body | Erythema infectiosum/fifth disease |
| "Slapped cheeks" appearance, caused by parvovirus B19 | Erythema infectiosum/fifth disease |
| Another term used for Erythema Infectiosum? | Fifth disease |
| Chorea, dementia, caudate degeneration | Huntington disease |
| Autosomal dominant CAG repeat expansion | Huntington disease |
| Chorioretinitis, hydrocephalus, intracranial calcifications | Congenital toxoplasmosis |
| Chronic exercise intolerance with myalgia, fatigue, painful cramps, myoglobinuria | McArdle disease |
| Skeletal muscle glycogen phosphorylase deficiency | McArdle disease |
| Cold intolerance | Hypothyroidism |
| Conjugate horizontal gaze palsy, horizontal diplopia | Internuclear ophthalmoplegia |
| Damage to MLF | Internuclear ophthalmoplegia |
| Continuous "machine-like" heart murmur | PDA |
| Which murmur is closed with Indomethacin? | PDA |
| PDA is kept open with: | PGE analogues |
| Cutaneous/dermal edema due to connective tissue deposition | Myxedema |
| What conditions are associated with Myxedema? | Hypothyroidism, Graves disease ([pretibial]) |
| Cutaneous flushing, diarrhea, bronchospasm | Carcinoid syndrome |
| Right-sided cardiac valvular lesions, increased 5-HIAA | Carcinoid syndrome |
| Dark purple skin/mouth nodules in a patient with AIDS | Kaposi sarcoma |
| Which virus is associated with Kaposi sarcoma? | HHV-8 |
| Deep, labored breathing/hyperventilation and Hx of increased HbA1 | Diabetic ketoacidosis |
| Kussmaul respiration are common in which diabetic complication? | Diabetic ketoacidosis |
| Dermatitis, dementia, diarrhea | Pellagra |
| Niacin (vitamin B3) deficiency | Pellagra |
| Dilated cardiomyopathy, edema, alcoholism or malnutrition | Wet beriberi |
| Thiamine (Vit B1) deficiency and Dilated cardiomyopathy | Wet beriberi |
| Dog or cat bite resulting in infection | Pasteurella multocida |
| Cellulitis art inoculation site | Pasteurella multocida |
| Dry eyes, dry mouth, arthritis | Sjogren syndrome |
| Autoimmune destruction of exocrine glands | Sjogren syndrome |
| Dysphagia (esophageal webs), glossitis, iron deficiency anemia | Plummer-Vinson syndrome |
| What is a possible complication of Plummer-Vinson syndrome? | Esophageal Squamous Cell carcinoma |
| Elastic skin, hypermobility of joints, and increased bleeding tendency | Ehlers-Danlos syndrome |
| Type V collagen defect, type III collagen defect seen in vascular subtype of ED | Ehlers-Danlos syndrome |
| Enlarged, hard left supraclavicular node | Virchow node |
| Episodic vertigo, tinnitus, hearing loss | Meniere disease |
| Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells | Mycosis fungoides or Sezary syndrome |
| Cutaneous T cell lymphoma | Mycosis fungoides |
| Mycosis fungoides + malignant T cells in the blood | Sezary syndrome |
| Facial muscle spasm upon tapping | Chvostek sign |
| Positive Chvostek sign | Hypocalcemia |
| Fat, female, forty, and fertile | Cholelithiasis |
| Medical terminology for gallstones | Cholelithiasis |
| Fever, chills, headache, myalgia following antibiotic treatment for syphilis | Jarisch-Herxheimer reaction |
| Rapid lysis of spirochetes results in Endotoxin release | Jarisch-Herxheimer reaction |
| Fever, cough, conjunctivitis, coryza, diffuse rash | Measles |
| Fever, night sweats, weight loss | B symptoms (staging) of lymphoma |
| Fibrous plaques in soft tissue of penis wit abnormal curvature | Peyronie disease |
| Connective tissue disorder of the penis | Peyronie disease |
| Golden brown rings around peripheral cornea | Wilson disease |
| Kayser-Fleischer rings due to copper accumulation | Wilson disease |
| Gout, intellectual disability, self-mutilating behavior in a boy | Lesch-Nyhan syndrome |
| HGPRT deficiency, X-linked recessive | Lesch-Nyhan syndrome |
| Hamartomatous GI polyps, hyperpigmentation of mouth/feet/hands/genitalia | Peutz-Jeghers syndrome |
| Inherited, benign polyps can cause bowel obstruction; increased cancer risk, mainly GI | Peutz- Jeghers syndrome |
| Hepatosplenomegaly, pancytopenia, osteoporosis, aseptic necrosis of femoral head, bone crises | Gaucher disease |
| Glucocerebrosidase deficiency | Gaucher disease |
| Hereditary nephritis, sensorineural hearing loss, cataracts | Alport syndrome |
| Mutation in collagen IV | Alport syndrome |
| Hyperphagia, hypersexuality, hyperorality, hyperdocility | Kluver-Bucy syndrome |
| Bilateral amygdala lesion | Kluver-Bucy syndrome |
| Hyperreflexia, hypertonia, Babinski sign present | UMN damage |
| Hyporeflexia, hypotonia, atrophy, fasciculations | LMN damage |
| Situs inversus, chronic sinusitis, bronchiectasis, infertility | Kartagener syndrome |
| Dynein arm defect affecting cilia | Kartagener syndrome |
| Slow, progressive weakness in boys | Becker muscular dystrophy |
| X-linked missense mutation in dystrophin; less severe than Duchenne | Becker muscular dystrophy |
| Infant with cleft lip/palate, microcephaly or holoprosencephaly, polydactyly, cutis aplasia | Patau syndrome |
| Trisomy 13 | Patau syndrome |
| Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect | Edwards syndrome |
| Trisomy 18 | Edwards syndrome |
| Single palmar crease | Down syndrome |
| Swollen gums, mucosal bleeding, poor wound healing, petechiae | Scurvy |
| Vitamin C deficiency causes: | Scurvy |
| What is the biochemical deficient in Vitamin C deficiency? | Cannot hydroxylate proline/lysine for collagen synthesis |
| Infant with hypoglycemia, hepatomegaly | Cori disease or Von Gierke disease |
| Cori disease is due to missing | Debranching enzyme |
| Von Gierke disease is due to missing | Glucose-6-phosphatase deficiency |
| Myopathy, exercise intolerance, and infantile hypertrophic cardiomyopathy | Pompe disease |
| What enzyme deficiency causes Pompe disease? | Lysosomal a-1, 4-glucosidase |
| Male child, recurrent infections, no mature B cells | Bruton disease |
| X-linked agammaglobulinemia | Bruton disease |
| Recurrent cold (noninflamed) abscesses, unusual eczema, high serum IgE | Hyper-IgE syndrome |
| What is another name for Hyper-IgE syndrome? | Job syndrome |
| Neutrophil chemotaxis abnormality is seen inJ: | Hyper-IgE syndrome |
| "Strawberry tongue" | Scarlet Fever and Kawasaki disease |
| Red "currant jelly" sputum in alcoholic or diabetic patients | Klebsiella pneumoniae pneumonia |
| Large rash with bull's-eye appearance | Erythema chronicum migrans form Ixodes tick bite |
| What organism causes Lyme disease? | Borrelia |
| Indurated, ulcerated genital lesion, and NON-painful | Chancre |
| What organism and disease is associated with genital chancre? | Primary syphilis caused by Treponema pallidum |
| Induced, ulcerated genital lesion, painful and with exudate | Chancroid |
| What is the most common cause of a chancroid? | Haemophilus ducreyi infection |
| Pupil accommodates but does not react | Argyll Robertson pupil |
| What condition is seen with Argyll Robertson pupil? | Neurosyphylis |
| Smooth, moist, painless, wart-like white lesions on genitals | Condylomata lata |
| Condylomata late is associated with which stage of syphilis? | Second stage |
| "Worst headache of my life" | Subarachnoid hemorrhage |
| Weight loss, diarrhea, arthritis, fever, adenopathy | Whipple disease |
| What condition is caused by Tropheryma whipplei? | Whipple disease |
| Vomiting blood following gastroesophageal lacerations | Mallory-Weiss syndrome |
| Mallory-Weiss syndrome is often seen in: | Alcoholics and bulimic patients |
| Vascular birthmark of the face | Nevus flammeus |
| What is the classical description of vascular birthmark in Sturge-Weber syndrome | Port-wine stain |
| Benign, but associated with Sturge-Weber syndrome? | Nevus flammeus |
| Urethritis, conjunctivitis, arthritis in a male | Reactive arthritis associated with HLA-B27 |
| Unilateral facial drooping involving forehead | LMN facial nerve (CN VII) palsy |
| Which kind of Motor neuron damage of CN VII palsy spare the forehead? | UMN |
| Toe extension/ fanning upon plantar scape | Babinski sign |
| Adult UMN lesion is often presented with a positive | Babinski sign |
| Thyroid tumors, pheochromocytoma, ganglioneuromatosis | MEN 2B |
| Autosomal dominant RET mutation | MEN 2A and MEN 2B |
| Thyroid and parathyroid tumors, pheochromocytoma | MEN 2A |
| Telangiectasias, recurrent epitalis, skin discoloration, arteriovenous malformations, GI bleeding, hematuria | Osler-Weber-Rendu syndrome |
| Systolic ejection murmur (crescendo-decrescendo) | Aortic stenosis |
| Swollen, hard, painful finger joints | Osteoarthritis |
| Osteophytes on PIP (Bouchard nodes), DIP (Heberden nodes) | Osteoarthritis |
| What two classical joint nodes are associated with Osteoarthritis? | Bouchard nodes (PIP) and Heberden nodes (DIP) |
| Sudden swollen/painful big toe joint, tophi | Gout/podagra |
| What kind of electrolyte imbalance is associated with the development of Gout? | Hyperuricemia |
| Streak ovaries, congenital heart disease, horseshoe kidney, cystic hygroma at birth, short stature, webbed neck, lymphedema | Turner syndrome |
| 45, XO | Turner syndrome |
| Splinter hemorrhages in fingernails | Bacterial endocarditis |
| Small, irregular red spots, on buccal/lingual mucosa with blue-white centers | Koplik spots |
| Koplik spots are associated with: | Measles virus |
| Another name for rubeola virus | Measles virus |
| Skin hyperpigmentation, hypotension, fatigue | Primary adrenocortical insufficiency |
| What is the common name for Primary adrenocortical insufficiency? | Addison disease |
| What hormonal imbalances are primary in Addison disease? | Increased ACTH and Increased a-MSH production |
| The hyperpigmentation in Addison disease is due to: | Increased a-MSH production |
| Short stature, cafe au lait spots, thumb/radial defects, increased incidence of tumors/leukemia, aplastic anemia | Fanconi anemia |
| Genetic loss of DNA crosslink repair; often progresses to AML | Fanconi anemia |
| Severe jaundice in neonate | Crigler-Najjar syndrome |
| Severe congenital unconjugated hyperbilirubinemia | Crigler-Najjar syndrome |
| Retinal hemorrhages with pale centers | Roth spots |
| Name of ocular signs in Bacterial endocarditis | Roth spots |
| Resting tremor, rigidity, akinesia, postural instability, shuffling gait | Parkinson disease |
| Loss of dopaminergic neurons in substantia nigra pars compacta | Parkinson disease |
| Renal cell carcinoma (bilateral), hemangioblastomas, angiomatosis, pheochromocytoma | von-Hippel-Lindau disease |
| Red urine in the morning, fragile RBCs | Paroxysmal nocturnal hemoglobinuria |
| Red, itchy, swollen rash of nipple/areola | Paget disease of the breast |
| Sign of underlying breast neoplasm | Paget disease of the breast |
| Red "currant jelly" stools | Acute mesenteric ischemia (adults), intussusception (children) |
| Rash on palms and soles | Coxsackie A, Secondary syphilis, Rocky Mountain spotted fever |
| Rapidly progressive limb weakness that ascends following GI/upper respiratory infection | Guillain-Barre syndrome |
| Acute inflammatory demyelinating polyradiculopathy subtype | Guillain-Barre syndrome |
| Ptosis, miosis, anhidrosis | Horner syndrome |
| Pruritic, purple, polygonal planar papules and plaques (6 P's) | Lichen planus |
| Polyuria, renal tubular acidosis type II, growth failure, electrolyte imbalances, hypophosphatemic rickets | Fanconi syndrome |
| Multiple combined dysfunction of the proximal convoluted tubule | Fanconi syndrome |
| Pink complexion, dyspnea, hyperventilation | Emphysema |
| "Pink puffer", | Emphysema |
| Smoking emphysema | Centriacinar emphysema |
| Alpha-1-deficiency emphysema | Panacinar emphysema |
| Periorbital and/or peripheral edema, proteinuria (>3.5g/day), hypoalbuminemia, hypercholesterolemia | Nephrotic syndrome |
| Pancreatic, pituitary, parathyroid tumors | MEN 1 |
| Palpable purpura on buttocks/legs, joint pain, abdominal pain (child), hematuria | Henoch-Schonlein purpura |
| IgA vasculitis affecting skin and kidneys | Henoch-Schonlein purpura |
| Painless jaundice | Cancer of the pancreatic head obstruction bile duct |
| Painless erythematous lesions on palms and soles | Janeway lesions |
| Infective endocarditis, septic emboli/microabscesses | Janeway lesions |
| Jaundice, palpable distended non-tender gallbladder | Courvoisier sign |
| Distal malignant obstruction of biliary tree | Courvoisier sign |
| Lucid interval after traumatic brain injury | Epidural hematoma |
| Middle meningeal rupture | Epidural hematoma |
| Mucosal bleeding and prolonged bleeding time | Glanzmann thrombasthenia |
| Defect in platelet aggregation due to lack of GpIIb/IIIa | Glanzmann thrombasthenia |
| Muffled heart sounds, distended neck veins, hypotension | Beck triad of cardiac tamponade |
| Multiple colon polyps, osteomas/soft tissue tumors, impacted/supernumerary teeth | Gardner syndrome |
| Subtype of FAP | Gardner syndrome |
| Neonate with arm paralysis following difficult birth | Erb-Duchenne palsy |
| Superior trunk [C5-C6] brachial plexus injury | Erb-Duchenne palsy |
| What is the classical sign of Erb-Duchenne palsy? | "waiter's tip" |
| No lactation postpartum, absent menstruation, cold intolerance | Sheehan syndrome |
| Pituitary infarction | Sheehan syndrome |
| Painful blue fingers/toes, hemolytic anemia | Cold agglutinin disease |
| Autoimmune hemolytic anemia caused by Mycoplasma pneumoniae, infectious mononucleosis, CLL | Cold agglutinin disease |
| Painful fingers/toes changing color form blue to white to red with cold or stress | Raynaud phenomenon |
| Vasospasms in extremities | Raynaud phenomenon |
| Severe RLQ pain with palpation of LLQ | Rovsing sign |
| (+) Rovsing sign | Acute appendicitis |
| Severe RLQ pain with deep tenderness | McBurney sign |
| What is the most common sign in acute appendicitis? | McBurney sign |