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Microbiology

DNA and RNA viruses

QuestionAnswer
What are the 7 Viral families of DNA viruses? 1. Herpesviruses 2. Poxviruses 3. Hepadnavirus 4. Adenovirus 5. Papillomavirus 6. Polyomavirus 7. Parvovirus
Which DNA viral families are ENVELOPED? Herpesviruses, Poxvirus, and Hepadnavirus
What is the DNA structure of Poxvirus? Enveloped, linear, ds-DNA
Which is the largest DNA virus? Poxvirus
Which DNA viruses are enveloped, linear, ds-DNA? Herpesviruses and Poxviruses
Which are the unenveloped (naked) DNA viral families? 1. Adenovirus 2. Papillomavirus 3. Poliovirus 4. Parvovirus
Enveloped, circular, partially ds-DNA virus? Hepadnavirus
What are the medical important Poxviruses? 1. Smallpox 2. Cowpox 3. Molluscum contagiosum
What is Molluscum contagiosum? Flesh-colored papule with central umbilication caused by Poxvirus.
What is the most important Hepadnavirus? HBV
Unenveloped, linear, ds-DNA virus? Adenovirus
What are the important or medically relevant Adenoviruses complications? 1. Febrile pharyngitis - sore throat 2. Acute hemorrhagic cystitis 3. Pneumonia 4. Conjunctivitis - "Pink eye"
What virus is implicated in the development of "Pink eye"? Adenovirus
What is the structural-genomic description of Papillomavirus? Undeveloped, circular, ds-DNA
What is the most commonly referred Papillomavirus? HPV
Which HPV serotypes cause warts? 1, 2, 6, 11
HPV 1, 2, 6, and 11 are causative of? Warts
Which HPV serotypes are associated with cervical cancer development? 16 and 18
JC virus and BK virus are both _______________________. Polyomavirus
Which DNA viral families have a naked, circular, and ds-DNA structure? Papillomavirus and Polyomavirus
JC virus often causes: Progressive multifocal Leukoencephalopathy (PML) in HIV.
Which population is at higher risk of developing PML? HIV due to JC infection.
BK virus most commonly affects the __________________. Kidneys of transplant patients
Renal transplant patients are at higher risk of ________________ infection. BK virus
Which is the smallest DNA virus? Parvovirus
Undeveloped, linear, ssDNA virus? Parvovirus
B19 virus causes: Aplastic crises in sickle cell disease, "slapped cheeks" rash in children
What is the infection caused by B19 virus? Erythema infectiosum, or Fifth disease.
What is a complication of Parvovirus infection in pregnant women? Hydrops fetalis, due to RBC destruction in fetus
Pure RBC aplasia and Rheumatoid arthritis-like symptoms, is often seen in? B19 viral infection in healthy adults.
Which RNA viral families are Naked (Unenveloped)? 1. Reoviruses 2. Picornaviruses 3. Hepevirus 4. Caliciviruses
All RNA viral families are single-stranded (ss)- RNA, except for _______________. Reovirus (ds-RNA)
Which are the segmented viruses? BOAR: Bunyaviruses Orthomyxoviruses Arenaviruses Reoviruses
What does been negative-stranded mean? Must transcribe (-) negative strand to (+) positive. Virion brings its own RNA-dependent RNA polymerase.
Which type of RNA viruses have to carry and transport their own RNA-dependent RNA polymerase? Negative-stranded viruses
What is the mnemonic used for Negative-stranded viruses? Always Bring Polymerase Or Fail Replication
Which are the negative-stranded viruses? Arenaviruses Bunyaviruses Paramyxoviruses Orthomyxoviruses Filoviruses Rhabdoviruses
Unenveloped, ds-RNA, linear, segented, and Icosahedral? Reovirus
What are the 2 medically relevant Reoviruses? 1. Coltivirus --- Colorado tick fever 2. Rotavirus --- #1 cause of fatal diarrhea in children
Rotavirus is an: Reovirus Causes: most common cause of fatal diarrhea in children
What is the genomic description of Picornaviruses? Unenveloped, (+)ss-RNA, linear, Icosahedral
What is the mnemonic used to remember all Picornaviruses? PERCH
PERCH: P - Poliovirus - polio-Salk/Sabin vaccines E - Echovirus -- aseptic meningitis R - Rhinovirus - "common cold" C - Coxsackievirus - aseptic meningitis; herpangina (mouth blisters, fever); hand, foot, and mouth disease; myocarditis; pericarditis. H- HAV - acute viral hepatitis
What is seen in Herpangina? Mouth blisters and fevers, due to Coxsackievirus infection.
What viral family causes Hand, Foot, and Mouth disease? Picornavirus
HEV is an? Hepevirus
What is the genomic structure of Hepevirus? Naked, (+) ss-RNA, linear, with Icosahedral capsid.
Norovirus is an ______________________. Calicivirus
What is caused by Norovirus? Viral gastroenteritis
Genomic structure of Caliciviruses are shared with which other RNA viral family? Hepevirus
What are the common Flaviviruses? - HCV - Yellow fever - Dengue - St. Louis encephalitis - West Nile virus
Dengue viral genome is described as? Enveloped,(+) ssRNA, linear, and icosahedral caspid
West Nile virus is an _______________________. Flavivirus
Medical relevant Togaviruses? Rubella, Eastern equine encephalitis, and Western equine encephalitis.
What is characteristic of different of Retroviral genomic structure? It has 2 copies
Which kind of viruses have a Reverse Trasncriptase Retroviruses
What are the two main Retroviruses? 1. HTLV --- T cell Leukemia 2. HIV ---- AIDS
How many segments are in Orthomyxoviruses? 8 segments
Arenaviruses have ____ segments 2
Which RNA viral familie has 3 segments? Bunyaviruses
How many segments are seen in Reoviruses? 10-12 segments
"Common cold", SARS, MERS are all ______________________. Coronaviruses
To which RNA viral family does the Influenza viruses belong? Orthomyxoviridae
What are the most common medical relevant Paramyxoviruses? 1. Parainfluenza ---- croup 2. RSV --- bronchiolitis in babies 3. Measles, Mumps
What is the most common treatment for RSV? Ribavirin
What diseases are caused by Filoviruses? Ebola/ Marburg hemorrhagic fever
What are the 2 most common Arenaviruses? 1. LCMV - lymphocytic choriomeningitis virus 2. Lassa fever encephalitis
What are the most common Bunyaviruses? - California encephalitis - Sandfly/ Rift Valley fevers - Crimean-Congo hemorrhagic fever - Hantavirus - hemorrhagic, pneumonia
HDV is a _____________ virus. Delta
What receptor is used by CMV? Integrins (heparan sulfate)
EBV uses which kind of receptor? CD21
What are the receptors used by HIV? CD4, CXCR4, CCR5
Rabies use which receptor? Nicotinic AChR
ICAM-1 receptor is used by _____________________. Rhinovirus
Created by: rakomi