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Molecular Bio: DNA Replication

DNA poly reads in which direction? RNA poly? Both read 3'-->5' (create strand 5'-->3')
What are the 2 main differences between DNA synthesis (rep) and RNA synthesis (trx)? RNA synthesis requires NO PRIMER, and has NO CORRECTION of mismatched pairs (low fidelity)
Which enzyme corrects mismatched pairs in DNA synthesis? What type of exonuclease activity is it? DNA poly III corrects mismatches (same enzyme doing the synthesis). It is 3'-->5' exonuclease.
RNA Reverse Transcriptase requires RNA Primer. True or False? True, because RNA Reverse Transcriptase is essentially a DNA Poly.
Which enzyme synthesizes leading strand in prokaryotes? Lagging strands (Okazaki fragments)? Both are done by DNA Poly III
Which enzyme REMOVES RNA Primer in Prokaryote DNA synthesis? What type of exonuclease is it? DNA Poly I, it is 5'-->3' exonuclease
Which enzyme REPLACES RNA Primer? DNA Poly I
What binds the Okazaki fragments? DNA Ligase (requires NAD)
What removes positive supercoils (give 2 names for the enzyme)? DNA Topoisomerase II (a.k.a. Gyrase)
What unwinds the DNA? Helicase. Stabilized by SSBs
3 enzymatic steps of Thymine Dimer removal Excision endonuclease-->DNA poly-->DNA Ligaes
Loss of mismatched bp removal leads to what syndrome? HNPCC (aka "Lynch Syndrome")
p53 guards the progression from which phase of the cell cycle? G1-->S
Name 2 gene mutations/inactivations that affect p53 activity, and name the associated disease? ATM gene -->Ataxia Telangectasia BRCA-1 -->breast,prostate,ovary BRCA-2 -->breast
Created by: jsad



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