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Pharm2 Chapter 40
| Question | Answer |
|---|---|
| 1. What is TB caused by | a. Mycobacterium tuberculosis |
| 2. How is TB transmitted | a. By humans via droplets |
| 3. Antitubercular drugs treat all forms of what | a. Mycobacterium |
| 4. How long does it take to have a positive reaction to a TB skin test | a. 6-8 weeks |
| 5. What happens in the first infectious episode stage of TB | a. Mild pneumonia like illness |
| 6. MDR (multi-drug resistant) TB is resistant to | a. Both isoniazid and rifampin |
| 7. What pt. teaching should be including when taking rifampin | a. Body may turn orange along with urine, eyes, and skin |
| 8. What is rifampin | a. Broad spectrum, kills offending organism by inhibiting protein synthesis, available in PO and IV forms, used alone in prevention or in combination for tx |
| 9. What is INH (isoniazid) | a. Most widely used antitubercular drug, given single dose prophylaxis or in combo for tx, kills mycobacteria by disrupting cell wall synthesis, common form PO |
| 10. INH is contraindicated in what type of pts | a. Thos with pervious INH associated hepatic injury or any acute liver disease |
| 11. First line antitubercular drugs are | a. Isoniazid, rifapentine, rifampin |
| 12. Second line antitubercular drugs are | a. Amikacin, levofloxacin |
| 13. What substance should be avoided at all costs when on antitubercular medications | a. Alcohol!! |
| 14. Protein wall synthesis inhibitors include | a. Streptomycin, kanamycin, rifampin, rifabutin |
| 15. Cell wall synthesis inhibitors include | a. Cycloserine, ethionaminde, and isoniazid |
| 16. What does the term bactericidal mean | a. Kill bacteria |
| 17. What does INH cause | a. B6 deficiency and liver toxicity |
| 18. What should be given with INH | a. Pyridoxine (b6) 50mg |
| 19. Rifampin can cause | a. Hepatitis and urine/ stool discoloration |
| 20. You should perform what before administering an antitubercular drug | a. Liver function studies and assess contraindications |
| 21. What is the major reason MDR develop | a. Noncompliance to drug regiment |
| 22. How long may therapy last on an antitubercular drug | a. 24 months |
| 23. Drugs are given how long after cultures become negative | a. 1-2 years |
| 24. You should monitor what in pts with diabetes when taking an antitubercular drug | a. Blood glucose and signs of hyperglycemia |
| 25. INH and rifampin do what to contraceptives | a. Cause them to become ineffective, other forms will be needed |
| 26. B6 (pyridoxine) may be needed to combat what | a. Neurologic side effects associated with INH therapy |
Created by:
cspearsall
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