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Biology Chapter 3
Study Activities for Antimicrobial MCB2010
| Question | Answer |
|---|---|
| The ______ the therapeutic index the better the drug. | higher |
| This chemotherapeutic agent acts to inhibit protein synthesis by binding to the 30S ribosomal subunit and inhibiting amino acyl t-RNA binding. | Tetracycline |
| Name the 2 chemotherapeutic agents which act upon transpeptidization to inhibit cell wall synthesis. | Penicillin & Cephalosporin |
| These 2 chemotherapeutic agents disrupt the plasma membrane by acting on ergosterol in fungal cells. | Nystatin & Amphotericin B |
| The region surrounding a paper disk impregnated with the antibiotic, where the bacteria are not growing. | Zone of Inhibition |
| This chemotherapeutic agent acts to inhibit nucleic acid synthesis by binding to RNA Polymerase and blocking transcription. | Rifamycin |
| What is the major component of penicillin that makes it active? | Beta-lactam ring |
| What are the 2 anti-fungals that are systemic treatments? | Amphotericin B & Flucytosine |
| _____ spectrum drugs are effective against a wide range of pathogens. | Broad |
| Another name for the disk diffusion method to test antimicrobials using paper filter disks. | Kirby Bauer Test |
| Name the 2 chemotherapeutic agents which inhibit linear peptidoglycan formation, which inhibits cell wall synthesis. | Vancomycin & Bacitracin |
| The lowest concentration required to kill the microbe. | Minimal Bactericial Concentration |
| The term for agents which slow or limit the growth of the pathogen. | Bacteristatic |
| When a drug kills the infectious agent with low or no side effects to the host, it is said to be _____. | Selectively Toxic |
| This anti-viral drug is a Thymine analog which is used to treat HIV patients. | AZT |
| A superficial anti-fungal is _____. | Miconazole |
| The term for agents which kill the pathogen. | Bactericidal |
| _____ spectrum drugs are effective against a limited range of pathogens. | Narrow |
| The lowest concentration required to limit the growth of the microbe. | Minimal Inhibitory Concentration |
| This anti-viral drug works to prevent Influenza A infections. | Amantadine |
| These chemotherapeutic agents work to block folic acid synthesis, thus inhibiting a key enzymatic process. | Sulfonamides |
| Streptomycin, Spectinomycin, Chlormaphenicol, Clindimycin, Erythromycin, Gentamycin, Tetracycline | 7 drugs to Inhibit Protein Synthesis |
| What is the main sterol component in fungal plasma membranes? | Ergosterol |
| This chemotherapeutic agent acts to inhibit nucleic acid synthesis by inhibiting DNA Gyrase. | Quinolones |
| This chemotherapeutic agent disrupts the plasma membrane by acting as a surfactant. | Polymyxin |
| The _______ measures the toxic dose over the therapeutic dose. | Therapeutic Index |
| This anti-viral drug is a Guanine analog which is used to treat genital herpes patients. | Acyclovir |
| What is another name for penicillinase? | Beta-lactamase |
| This chemotherapeutic agent acts to inhibit protein synthesis by inhibiting peptidyl transferase, by binding to the 50S ribosomal subunit. | Chloramphenicol |
| Another name for 6-amino penicillanic acid? | Penicillin |
| This chemotherapeutic agents acts to inhibit protein synthesis by binding to the 30S ribosomal subunit, causing mis-reading of the mRNA. | Streptomycin |
| What is the main sterol component in animal cell plasma membranes? | Cholesterol |
Created by:
mikec35-pbsc
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