Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how



1. person with an immunodeficiency disorder will have frequent infections that are generally more severe and last longer than usual
2. primary immunodeficiency genetic or developmental
3. secondary immunodeficiency acquired
4. consequences of HIV infection decreased CD4positive cell function, altered T cell function, polyclonal B cell activation, and altered macrophage function
5. immunodeficiency mechanisms dysregulation, dna repair defects, low Ig, combined
6. Stem cell defect in pro-B cell differentiation Adenosine deaminase (ADA), Purine nucleoside phosphorylase (PNP)
7. Stem cell defect in pro-T cell differentiation Janus Kinase 3 (JAK3), (ADA), (PNP)
8. Pre-Bcell differentiation defect RAG1 RAG2 Artemis, BTK
9. Pre Tcell differentiation defect RAG 1 RAG2 Artemis, CD45, CD3
10. CD8 Tcell differentiation issue ZAP70, TAP 1,2
11. CD4 Tcell differentiation issue MHCII
12. ADA SCID deficiency ADA on chromosome 20 defect, reduced DNA synthesis NK, B and T cell problem, undeveloped thymus, rib abnormalities, low WBC, No T-cell response to nonspecific T-cell mitogen phytohemagglutinin, Failure to thrive, bone marrow transplant
13. PNP SCID deficiency NP on chromosome 14 defect, poor B cell activation of T cells, No T cells, B cells not functional, no thymus, Failure to thrive, neuro problems, hemolytic anemia, bone marrow transplant
14. RAG1,2 SCID RAG1,2 on chromosome 11 defect, no T or B cell, sequence gene to diagnose, no thymus, Failure to thrive, bone marrow transplant
15. Omenn syndrome missense mutations in RAG1 of RAG2, T-cell (target self), High IgE, exfoliative dermatitis, Failure to thrive, High IL4 IL5, high eosinophils
16. Gamma chain X linked SCID IL2RG - γ chain of cytokine receptor for IL-2, IL-4, IL-7, IL-9, IL-15 on X chromosome, No Tcells, no thymus, no Ig, no NK, normal B, Failure to Thrive
18. Wiskott Aldrich Syndrome WAS on X chromosome, involved in T cell signaling, Low B, T and NK, High IgA IgE, Low IgM, increased staphA infections and eczema, petechial rashes, bloody diarrhea
19. Leukocyte adhesion deficiency CD18 defective coreceptor for leukocyte phagocytosis, no puss, neutrophilia, delayed detachment of the umbilical cord
20. Chediak-Higashi Syndrome LYST gene defect, Infections, Neuropathy, Albinism, malfunctioning WBC with a diminished phagocytic capability, Defective phagocytosis in neutrophils, macrophages, dendritic cells, large granules in phagocytes
21. Chronic Granulomatous Disease Caused by multiple potential mutations in NADPH oxidase. NBT test negative, recurrent catalase positive infections, granuloma, colitis, recurrent fungal infections
22. DiGeorge Syndrome chromosome 22 (22q11) containing the T-box 1 (TBX1) gene deletion, embryonic thymic and parathyroid aplasia, No Tcells, Low Ig, cardiac abnormality
23. MHC II difficiency CIITA (MHCII transactivator) on chromosome 16 or RFX (Regulatory factor X1) on chromosome 1 defect. double positive T-cells cannot undergo positive MHCII selection, Low Ig, CD8 cells normal, no CD4, graft vs host disease
24. MHC I deficiency TAP1,2 gene, B2microglobulin gene defect, CD4 cells normal, no CD8 cells, Normal Ig, Chronic viral infections, skin lesions
25. Selective IgA deficiency no heavy chain class switching, low IgA, Sinopulmonary infections and UTIs, B cell defect
26. X linkes Agammaglobulinemia BTK defect, No CD19, no B cell, no Ig
27. Hyper IgM syndrome CD40L deficiency, NEMO deficiency, AID deficiency for class switching, T cell defective cant stimulate B cell class switch, high IgM
28. NEMO Deficiency (X-linked hypohidrotic ectodermal dysplasia) defect on IKBKG gene, cant activate NK-kB pathway, high IgA or IgM other Ig low, have thickened skin, conical teeth, absence of sweat glands, and thin, sparse hair
29. Activation-induced Cytidine Deaminase (AID) Deficiency class switching gene, only IgM
30. Common Variable Immune Deficiency (CVID) normal B cells, no plasma cells inability to produce antibodies in response to polysaccharide vaccines
31. C1, C2, C2 deficiency SLE and pyogenic infections
32. C3 deficiency severe pyogenic infections, SLE, glomulnephritis
33. Late complement deficiency sepsis, meningitis, disseminated gonococcal infections
34. C1 esterase inhibitor deficiency recurrent angioedema
35. DAF, CD55, CD59 deficiency nocturnal hemoglobulinemia
36. PIGA gene provides instructions for making a protein called phosphatidylinositol glycan class A, mutation causes Paroxysmal nocturnal hemoglobinuria (PNH)
Created by: splashgreen



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards