Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how


Adaptive immune regulation pt. 1

Circulating B cells that have not encountered antigen are known as naive B cells
Co-expression of IgD and IgM is regulated by RNA processing
Ig that feedback inhibits B cell activation IgG
FcyRIIB (CD32) found in B cells, DC, mast cells, Neutrophills, Macrophages: Feedback INHIBITS Bcells and inflammation
FcyRI (CD 64) on macrophages, neutrophils, eosinophils: Phagocytosis activation
FcyRIIA (CD32) on macrophages, neutrophils, eosinophils, platelets: inefficient Phagocytosis activation
FcyRIIIA (CD16) binds IgG on NK cells for antibody dependent cell cytotoxicity
FceRI binds IgE on Mast cells, basophils, eosinophils for degranulation. Enhanced by IL5 from Th2 cells
Functions of complement pathway phagocytosis, cytolysis, inflammation
lymphocytes may be activated to proliferate and differentiate immunogenic antigen
lymphocytes that are functionally inactivated or killed tolerogenic antigen
Types of Peripheral T cell tolerance cell-intrinsic anergy, suppression by regulatory T cells, deletion (apoptotic cell death)
Tcell Anergy recognizes antigen without strong costimulation, may lose their ability or be blocked by CTLA-4
Tcell suppression by reg.T cells self recognizing T cell in thymus stimulated by FoxP3 and IL2
T cell Apoptosis pro-survival IL2 secreted usually, without co-stimulation self antigen recognition may lead to expression of death receptors and their ligands, such as Fas and Fas ligand (FasL),
Central tolerance If the self antigen is recognized weakly (with low avidity), the B cell reduces antigen receptor expression and becomes functionally unresponsive. If binds strongly = apoptosis
Peripheral Tolerance mature B cell recognizes a self antigen without T cell help is functionally inactivated and becomes incapable of responding to that antigen (anergy), or dies by apoptosis (deletion), or its activation is suppressed by engagement of inhibitory receptors.
B cells can shut off antibody production via antibody feedback where antibody bound to antigen inhibits further antibody production with FcyRIIB
BAFF is a B cell–activating cytokine that may be involved in switching to IgA, especially in T-independent responses.
B cell switching to IgA TGFB, BAFF
B cell switching to IgE IL4
B cell switching to IgG INF-y
Created by: splashgreen



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards