Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
MUA M2B2 IDR 03
Adaptive immune regulation pt. 1
| Term | Definition |
|---|---|
| Circulating B cells that have not encountered antigen are known as | naive B cells |
| Co-expression of IgD and IgM is regulated by | RNA processing |
| Ig that feedback inhibits B cell activation | IgG |
| FcyRIIB (CD32) | found in B cells, DC, mast cells, Neutrophills, Macrophages: Feedback INHIBITS Bcells and inflammation |
| FcyRI (CD 64) | on macrophages, neutrophils, eosinophils: Phagocytosis activation |
| FcyRIIA (CD32) | on macrophages, neutrophils, eosinophils, platelets: inefficient Phagocytosis activation |
| FcyRIIIA (CD16) | binds IgG on NK cells for antibody dependent cell cytotoxicity |
| FceRI | binds IgE on Mast cells, basophils, eosinophils for degranulation. Enhanced by IL5 from Th2 cells |
| Functions of complement pathway | phagocytosis, cytolysis, inflammation |
| lymphocytes may be activated to proliferate and differentiate | immunogenic antigen |
| lymphocytes that are functionally inactivated or killed | tolerogenic antigen |
| Types of Peripheral T cell tolerance | cell-intrinsic anergy, suppression by regulatory T cells, deletion (apoptotic cell death) |
| Tcell Anergy | recognizes antigen without strong costimulation, may lose their ability or be blocked by CTLA-4 |
| Tcell suppression by reg.T cells | self recognizing T cell in thymus stimulated by FoxP3 and IL2 |
| T cell Apoptosis | pro-survival IL2 secreted usually, without co-stimulation self antigen recognition may lead to expression of death receptors and their ligands, such as Fas and Fas ligand (FasL), |
| Central tolerance | If the self antigen is recognized weakly (with low avidity), the B cell reduces antigen receptor expression and becomes functionally unresponsive. If binds strongly = apoptosis |
| Peripheral Tolerance | mature B cell recognizes a self antigen without T cell help is functionally inactivated and becomes incapable of responding to that antigen (anergy), or dies by apoptosis (deletion), or its activation is suppressed by engagement of inhibitory receptors. |
| B cells can shut off antibody production via | antibody feedback where antibody bound to antigen inhibits further antibody production with FcyRIIB |
| BAFF | is a B cell–activating cytokine that may be involved in switching to IgA, especially in T-independent responses. |
| B cell switching to IgA | TGFB, BAFF |
| B cell switching to IgE | IL4 |
| B cell switching to IgG | INF-y |
Created by:
splashgreen
Popular USMLE sets