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Drug Reactions

FA Review

QuestionAnswer
Coronary Vasospasms are caused by: Cocaine, Amphetamines, Sumatriptan, Ergot Alkaloids
What mnemonic is used to remember drugs that may cause Coronary Vasospasms? CASE: Cocaine Amphetamine Sumatriptan Ergot Alkaloids
Cutaneous Flushing Vancomycin, Adenosine, Niacin, Ca2+ channel blockers, Echinocandins, Nitrates
What is Red man syndrome? Rate-dependent infusion reaction to VANCOMYCIN causing widespread pruritic erythema.
What is the treatment for Red man Syndrome? Diphenhydramine pretreatment and slower infusion rate of Vancomycin
Dilated Cardiomyopathy is associated with: Anthracyclines (Doxorubicin, Daunorubicin)
How is anthracycline-induced DMC prevented? by using Dexrazoxane
What specific effect have those drugs that cause Torsades de Pointes? Prolong QT interval
What drugs are associated with development of Torsades de Pointes? -antiarrhythmics (class IA and III) -antibiotics (macrolides) - antipsychotics (haloperidol) -antidepressants (TCSs) -antiemetics (ondansetron)
Adrenocortical insufficiency is due to: HPA suppression secondary to glucocorticoid withdrawal
What drugs may induce Diabetes Insipidus? Lithium and Demeclocycline
Side effect of SERMs? Hot flashes
What are common SERMs? Tamoxifene, Clomiphene, and Raloxifene
Hyperglycemia: Tacrolimus, Protease inhibitors, Niacin, HCTZ, and Corticosteroids
What is the clinical presentation of Hyperprolactinemia? Hypogonadism (infertility, amenorrhea, erectile dysfunction) and galactorrhea (more common in men)
What drugs are associated with the development of Hyperprolactinemia? - Typical antipsychotics (haloperidol) -Atypical antipsychotics (quetiapine) - Metoclopramide -Methyldopa
Hyperthyroidism is a drug reaction to: Lithium and Amiodarone
Hypothyroidism is seen as SE of: Amiodarone, Sulfonamides, and Lithium
Which drugs are associated with the development of SIADH? Carbamazepine, Cyclophosphamide, and SSRIs
Macrolides are associated with what GI drug reactions? Acute cholestatic hepatitis and Jaundice
Diarrhea is often a SE to the use of any of the following: 1. Acamprosate 2. Antidiabetic agents (acarbose, metformin, pramlintide) 3. Colchicine 4. Cholinesterase inhibitors 5. Lipid-lowering agents (ezemtibide, orlistat) 6. Macrolides (erythromycin) 7. Quinidine 8. SSRIs
What drugs are associated with "focal to massive hepatic necrosis"? Halothane, Amanita phalloides (death cap mushroom), Valproic acid, and Acetaminophen
Death cap mushroom Amanita phalloides
Hepatitis is an adverse drug reaction to: Rifampin, Isoniazid, Pyrazinamide, Statins, and Fibrates
What two medications used in TB treatment are associated with the development of Hepatitis? Rifampin and Isoniazid
Which lipid lowering agents are associated with Hepatotoxicity (hepatitis)? Fibrates and Statins
Pancreatitis: Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)
What are the diuretics that may cause Pancreatitis? Furosemide and HCTZ
Pill-induced Esophagitis is seen with use of: Bisphosphonates, ferrous sulfate, NSAIDs, Potassium chloride, tetracyclines
What drugs are associated with Pseudomembranous colitis? Ampicillin, cephalosporins, clindamycin, and Fluoroquinolones
Antibiotics, such as ______, _______, ________, and ____________, predispose to superinfection by _________________________, which manifested by ______________________. Ampicillin, Cephalosporins, Clindamycin, and Fluoroquinolones; Resistant C difficile; Pseudomembranous colitis
Agranulocytosis is associated with: Clozapine, Carbamazepine, PTU, Methimazole, Colchicine, and Ganciclovir
Aplastic anemia may be induced by adverse effects of: Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, and PTU
What are two SE effects shared by PTU and Methimazole? Agranulocytosis and Aplastic anemia
What drugs yield produce a Direct Coombs-positive hemolytic anemia? Penicillin, methyldopa, and Cephalosporins
Eosinophilia + Systemic symptoms is seen with: Allopurinol, anticonvulsants, antibiotics, and sulfa drugs
What is DRESS? Potentially fatal delayed hypersensitivity reaction. Latency period (2-8 weeks) followed by fever, morbilliform skin rash, and frequency multiorgan involvement
Gray baby syndrome is caused by ____________________. Chloramphenicol
What are the associated drugs with the development of hemolysis in G6PD deficiency? Isoniazid, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
Megaloblastic anemia is produced by: Hydroxyurea, Phenytoin, Methotrexate, and Sulfa drugs
What drugs may develop Thrombocytopenia? Heparin, Vancomycin, and Linezolid
Thrombotic complications are seen with: - Combined oral contraceptives (OCPs) - Hormone replacement therapy - SERMs
Drug-induced lupus is seen with the use of: Methyldopa, Sulfa drugs, Hydralazine, Isoniazid, Procainamide, Phenytoin, and Etanercept
Fat redistribution is an adverse reaction seen with: Protease inhibitors and Glucocorticoids
Gingival hyperplasia Cyclosporine, Ca2+ channels blockers, Phenytoin
Hyperuricemia (Gout) is caused as side effect of: Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
Myopathy is seen with: Statins, Fibrates, niacin, colchicine, daptomycin, hydroxychloroquine, INF-a, penicillamine, and glucocorticoids
Osteoporosis is an adverse effect of: Corticosteroids, depot medroxyprogesterone acetate, GnRH agonists, aromatase inhibitors, anticonvulsants, heparin, PPIs
Photosensitivity Sulfonamides, Amiodarone, Tetracyclines, and 5-FU
Rash (Stevens-Johnson syndrome) is caused by: 1. Antiepileptic drugs (especially Lamotrigine) 2. Allopurinol 3. Sulfa drugs 4. Penicillin
What is the main and most drastic SE of Lamotrigine? Stevens-Johnson syndrome
What kind of antibiotics cause teeth discoloration? Tetracyclines
Tendon and cartilage damage is seen with ___________________ improper use. Fluoroquinolones
What drugs can cause Cinchonism? Quinidine and Quinine
What is the clinical presentation of Cinchonism? Tinnitus, hearing/vision loss, psychosis, and cognitive impairment.
Parkinson-like syndrome is a SE of : Antipsychotics, Reserpine, and Metoclopramide
Peripheral neuropathy: Phenytoin, Vincristine/Vinblastine and Paclitaxel
What can cause Pseudotumor cerebri? Growth hormones, Tetracycline, and Vitamin A
What are common drugs that may cause SEIZURES? Isoniazid (vitamin B6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, and Enflurane
Tardive dyskinesia is caused by: Antipsychotics and Metoclopramide
Topiramate visual disturbance is ---> Blurred vision/diplopia, haloes
Digoxin visual disturbance --------> Yellow-tinged vision
Isoniazid visual disturbance is ------> Optic neuropathy/ color vision changes
What drug is associated with bilateral visual field defects? Vigabatrin
What category of medications may cause a Blue-tinged vision? PDE-5 inhibitors
Ethambutol is associated with: Color vision changes
What can cause Fanconi Syndrome? Cisplatin, Ifosfamide, expired tetracyclines, and tenofovir
Hemorrhagic cystitis is a common SE of: Cyclophosphamide and Ifosfamide
What drugs are associated with INTERSTITIAL NEPHRITIS? Penicillins, Furosemide, NSAIDs, PPIs, and sulfa drugs.
How cyclophosphamide-induced hemorrhagic cystitis prevented? Coadministration with Mesna
Dry cough is often presented with the use of _________________. ACE inhibitors
Which drugs are associated with the development of Pulmonary fibrosis? MTX, Nitrofurantoin, Carmustine, Bleomycin, Busulfan, and Amiodarone.
What drugs are associated with an ANTIMUSCARINIC drug reaction? Atropine, TCAs, H1-blockers, and antipsychotics
Disulfiram-like reaction is seen with: 1st-generation sulfonylureas, Procarbazine, certain Cephalosporins, Griseofulvin, Metronidazole
Nephrotoxicity/Ototoxicity is seen with: Loop diuretics, Aminoglycosides, cisplatin, Vancomycin, amphotericin B
Created by: rakomi