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Micro-Final Exam
Question | Answer |
---|---|
the science that studies when and where diseases occur and how they are transmitted | epidemiology |
study of disease | pathology |
term for cause of disease---microbial/autoimmune/etc? (ex: mosquito bite/Malaria) | etiology |
development of the disease; disease progression (ex: kidney failure, seizures, mental confusion) | pathogenicity |
microbes invading and overcoming the body defenses; start to see the symptoms | infection |
the body is out of balance, not functioning normally; homeostasis out of balance | disease |
competes with transient pathogenic microbes for resources helping to prevent infection; can be supplemented with probiotics, prebiotics can be harmful | resident flora (resident microbiota) |
how normal microbiota becomes opportunistic | relocation (E. coli moves from lower to upper GI), allowed to overgrow, weakened immune system, poor nutrition, stress |
not spread from host to host (ex: rabies---have to be bit by wild animal to get disease) | non-communicable |
can be spread from host to host (ex: common cold, flu) | communicable |
period of time when the disease is most easily and rapidly spread | contagious |
whole number (ex: how many people total? how many people in a month?); number of occurrences | incidence |
percentage of incidence per some other condition | prevalence |
random increases in incidence; only occur occasionally | sporadic |
rapid increase in incidence in a short amount of time | epidemic |
epidemic that is world wide | pandemic |
can always be found (more prevalent) in that group/area (race, geographic region) | endemic |
fast onset, short duration | acute |
slow onset, long duration | chronic |
between acute and chronic | subacute |
disease has an acute onset, then a long dormant period before disease occurs again | latent |
disease/infection limited to a small area of the host body (ex: sinus infection, fungal infection of toe) | local disease/infection |
involves multiple organ systems (ex: sepsis) | systemic |
occurred in one area, but disease involved multiple organ systems (ex: cancer) | focal infection/disease |
infection in the blood stream | septic/sepsis |
pathology that caused initial symptoms (ex: Grandma breaks hip) | primary pathology |
another pathology after/or as a result of the primary (ex: get hip surgery and get infection) | secondary pathology |
predisposing factors of secondary pathology | weakened immune system, illness, poor nutrition, stress, age, procedure |
contracted in a clinical facility | nosocomial, HAI |
***disease progression curve: stage 1 | incubation stage period; infection but no S/Sx |
***disease progression curve: stage 2 | prodromal (malaise); general discomfort (malaise) but no specific S/Sx |
***disease progression curve: stage 3 | disease stage; peak, get treatment |
***disease progression curve: stage 4 | convalescence; recovery period, stands but body is still healing |
directly transmitted from another host | direct transmission |
transmitted by fomite; water borne, food borne, airborne (droplet) | indirect transmission |
location where the microbe can frequently be found | reservoir |
something that carries the microbe/disease from one host to another | vector |
not usually new diseases; rapid increase in infections; potential to mutate and rapidly increase | emerging |
catalog all the characteristics of the disease and etiology | descriptive epidemiology |
work with the number; track incidence and prevalence | analytical (statistical) epidemiology |
research; field research | experimental epidemiology |
USA -- CDC; global -- WHO; state and local -- health departments | epidemiology agencies |
portals of entry for microbes | skin/parenteral, respiratory, digestive, urogenital |
term for # of microbes to make 50% of subjects sick | ID50 (Infectious dose at 50%) |
term for # of microbes to kill 50% of subjects | LD50 (lethal dose at 50%) |
degree of damage caused by a microbe to its host | virulence |
most common portal of entry | respiratory |
T or F? Portal of exit usually same as portal of entry. | True |
how does virus adhere to host cell? | antigen receptors |
how does bacteria/protozoa adhere to host cell? | surface proteins or sugars |
ways microbes avoid phagocytosis | biofilms/capsules, hide in mucous, hide in the phagocytes (Mycobacterium-- Acid fast -- Waxy lipids) |
an infectious microbe alters the proteins or carbohydrates on its surface and thus avoids a host immune response | antigen variation |
beta hemalytic enzyme that breaks down clots | coagulase |
enzyme that breaks down collagen | collagenase |
enzyme that absorbs iron to cause the body to increase RBC production, and decrease WBC production; shutting of immune system (immunosuppressed) | siderophores |
enzymes damage cell structure, producing wastes, cell rupture through reproduction, production of exotoxins | direct cell damage |
cell damage caused by endotoxins, using host nutrients | indirect cell damage |
effects of cell damage caused by viruses | cytopathic effects |
C. diff | bacteria, digestive |
Brucellosis | bacteria, digestive |
Hepatitis C | virus, skin |
Epstein-Barr | virus, digestive |
MRSA | bacteria, skin |
Rabies | virus, skin |
E. coli | bacteria, digestive |
Bordetella pertussis (Whooping cough) | bacteria, resp. |
Ebola | virus, skin |
Chlamydia | bacteria, urogenital |
Mycobacterium tuberculosis | bacteria, resp. |
Plasmodium (malaria) | protozoa, skin |
Candidiasis (Candida albicans) | fungus, urogenital |
prokaryotic domain and kingdom | Domain-Prokarya, Kingdom-bacteria |
process of bacterial growth/cell division | binary fission |
time it takes for the entire population to double | generation time |
bacterial standard growth curve steps | lag, log, stationary, death |
physical growth requirements of bacteria | temp, pH, osmotic pressure |
chemical growth requirements of bacteria | carbon source, N/H/P/S, O2, growth factors (signal growth phase to start or stop), vitamins/minerals/other trace elements |
prokaryotic cell shape: round, circular, oval | coccus/cocci |
prokaryotic cell shape: linear, rod-shaped | bacillus |
prokaryotic cell shape: spiral with one bend | vibrio |
prokaryotic cell shape: spiral with one complete turn | spiral |
prokaryotic cell shape: spiral with many turns (worm-like) | spirillium/spirocheate |
prokaryotic cell arrangement: no arrangement | spirals always have no arrangement |
prokaryotic cell arrangement: diplo | 2; coccus, bacillus |
prokaryotic cell arrangement: tetrads | 4; cocci |
prokaryotic cell arrangement: sarcinae | cube-like (8); cocci |
prokaryotic cell arrangement: strepto | chain; coccus, bacillus |
prokaryotic cell arrangement: staphylo | cluster; coccus |
prokaryotic cell arrangement: pallisades | stacked back to back like bookends; bacillus |
prokaryotic cell with one flagella | monotrichous |
prokaryotic cell with flagella at each pole | amphitrichous |
prokaryotic cell with clump of flagella at one pole | lophotrichous |
prokaryotic cell with flagella all over | peritrichous |
prokaryotic extracellular appendage found only on spirochetes | axial filaments |
prokaryotic extracellular appendage used for attachment to surfaces | fimbriae |
prokaryotic extracellular appendage used for attachment to other bacteria for transfer of DNA | pili |
prokaryotic "sugar coat" that protects prokaryote from the immune system and can also help prokaryote stick to surfaces (capsule, biofilm) | glycocaylax |
what makes up the prokaryotic cell wall? | peptidoglycans and lipids |
part of the prokaryotic cell that is a selectively permeable membrane | plasma membrane |
part of the prokaryotic cell that contains cytosol and other intracellular components | plasma membrane |
part of the prokaryotic cell that moves; it's the location of genetic material at any given time | nucleoid |
part of the prokaryotic cell responsible for protein synthesis | 70s ribosomes |
part of the prokaryotic cell that holds extra chromosomal DNA accumulated from other prokaryotes | plasmid |