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Reproductive 2

UWORLD + FA Reproductive (Male/Female), Childbirth, Pregnancy

QuestionAnswer
HPV infection affects affects the ________________________. Epithelial BASAL Cervical cells.
Cervical Intraepithelial Neoplasia (CIN) lesions are classified as __________________ and ____________________. Low-grade; High-grade
Invasion beyond the lower 1/3 of cervical epithelium due to HPV infection. High-grade CIN lesion.
What is koilocytic changes are seen with and its malignancy association? HPV causes Perinuclear Vacuolization; does not reflect any malignant or premalignant conditions.
What are common Androgen-receptor binding inhibitors (antiandrogens)? FLUTAMIDE, Cyproterone, and Spironolactone
What is the MoA of androgen-receptor binding inhibitors? Competitive inhibitors of Testosterone receptors
What kind of drugs are co-administered in the treatment of Prostate cancer? 1. Long-acting Continuous GnRH agonist 2. Androgen-receptor binding inhibitors
The use of a long-acting continuous GnRH agonist causes __________________________ in the treatment of Prostate cancer. 1. Decreased metastasis risk 2. REduction in size
What is the reason for of the co-administration of GnRH agonists and antiandrogens in treating Prostate cancer? Constant GnRH therapy cause a transient elevation of LH and FSH release (before desensitization), which are prevented with anti androgenic.
Created by: rakomi
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