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Endocrinology 1.2
UWORLD Endocrine Signaling Pathways
| Question | Answer |
|---|---|
| FLAT ChAMP | mnemonic of hormones that use cAMP |
| FSH, LH, TSH, CRH, hCG, ADH (V2-receptor), MSH, PTH, calcitonin, GHRH, glucagon, histamine (H2 receptor) | cAMP |
| Calcitonin uses: | cAMP |
| Glucagon uses: | cAMP |
| FSH and LH use ________________ as second messenger signaling pathway. | cAMP |
| What hormones use cGMP? | BNP, ANP, and EDRF (NO) |
| Think of vasodilators!! | cGMP |
| In cases the blood volume stretches the fibers of the myocardium, the atria and ventricles, secrete _________ and _______, respectevely, which use ________ as second mesenger. | cGMP |
| Nitric Oxide is also known as: | EDRF |
| EDRF or NO uses | cGMP |
| cGMP associated with | NO, BNP, ANP |
| GOAT HAG | mnemonic for hormones using IP3 |
| GnRH, Oxytocin, ADH (V1 receptor), TRH, Histamine (H1 receptor), Angiotensin II, and Gastrin, use _________. | IP3 |
| _______ is used by ADH ___ receptor and Histamine ____ receptor. | IP3; V1; H1 |
| cAMP has the -______ receptors, and IP3 has the -_____ receptors, for ADH and Histamine. | 2; 1 |
| ATT II uses ________. | IP3 |
| Which GI hormone used the IP3 signaling pathway? | Gastrin |
| Mnemonic used for intracellular receptors | PET CAT on TV |
| Use intracellular receptors: | Progesterone, Estrogen, Testosterone, Cortisol, Aldosterone, T3/T4, Vitamin D |
| Vitamin D has an _________________________ receptor | Intracellular receptor |
| Cortisol, Estrogen and T3 use an ______________________ receptor | Intracellular receptor |
| Sex hormone, Testosterone and Estrogen, use what type of second messenger system? | Intracellular receptor |
| MAP kinase pathway is related to the: | Receptor Tyrosine Kinase |
| Which hormones use the receptor tyrosine kinase? | Insulin, IGF-1, FGF, PDGF, and EGF |
| Growth factors use which signaling pathway? | Receptor Tyrosine Kinase |
| Insulin uses the ____________________________. | Receptor Tyrosine Kinase |
| Glucagon uses _______________ and Insulin uses ___________________. | cAMP; Receptor Tyrosine Kinase |
| The JAK/STAT pathway is associated with which signaling pathway? | NON-receptor Tyrosine Kinase |
| Which hormones use the NON-receptor Tyrosine Kinase pathway? | Prolactin, Immunomodulators (cytokines IL-2, IL-6, INF), GH, G-CSF, Erythropoietin, Thrombopoietin. |
| Cytokine that aids in activation of NK cells, uses which signaling pathway? | IL-2 uses the NON-receptor Tyrosine Kinase |
| During pregnancy the elevated level of progesterone inhibit the release of ________________, endocrine hormone, responsible for milk letdown. | Prolactin; NON-receptor Tyrosine Kinase |
| Patient complains of increasing hat size, and last year had to buy new wedding ring since it was to small. What is the most common Dx? any signaling pathway relation? | Patient has Acromegaly, most likely by Pituitary adenoma. It produces excessive GH in adults. The GH uses the NON-receptor Tyrosine Kinase Pathway. |
| IGF-1 | Receptor tyrosine kinase |
| FGF | Receptor tyrosine kinase |
| PDGF | Receptor tyrosine kinase |
| EGF | Receptor tyrosine kinase |
| Inulin | Receptor tyrosine kinase |
| G-CSF | Non-receptor tyrosinase kinase |
| Erythropoietin | Non-receptor tyrosinase kinase |
| Thrombopoietin | Non-receptor tyrosinase kinase |
| Prolactin | Non-receptor tyrosinase kinase |
| Cytokines | Non-receptor tyrosinase kinase |
| IL-1, IL-6, IFN | Non-receptor tyrosinase kinase |
| Growth Hormone | Non-receptor tyrosinase kinase |
| BNP and ANP | cGMP |
| EDRF | cGMP |
| Nitric Oxide | cGMP |
| Progesterone | Intracellular receptor |
| Estrogen | Intracellular receptor |
| Testosterone | Intracellular receptor |
| Cortisol | Intracellular receptor |
| Aldosterone | Intracellular receptor |
| T3 and T4 | Intracellular receptor |
| Vitamin D | Intracellular receptor |
| GnRH | IP3 |
| Oxytocin | IP3 |
| ADH (V1- receptor) | IP3 |
| TRH | IP3 |
| Histamine (H1-receptor) | IP3 |
| Angiotensin II | IP3 |
| Gastrin | IP3 |
| FSH | cAMP |
| LH | cAMP |
| TSH | cAMP |
| CRH | cAMP |
| hCG | cAMP |
| ADH (V2-receptor) | cAMP |
| MSH | cAMP |
| PTH | cAMP |
| Calcitonin | cAMP |
| Histamine (H2-receptor) | cAMP |
| Glucagon | cAMP |
| GHRH | cAMP |
Created by:
rakomi
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