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Endocrinology 1.2

UWORLD Endocrine Signaling Pathways

FLAT ChAMP mnemonic of hormones that use cAMP
FSH, LH, TSH, CRH, hCG, ADH (V2-receptor), MSH, PTH, calcitonin, GHRH, glucagon, histamine (H2 receptor) cAMP
Calcitonin uses: cAMP
Glucagon uses: cAMP
FSH and LH use ________________ as second messenger signaling pathway. cAMP
What hormones use cGMP? BNP, ANP, and EDRF (NO)
Think of vasodilators!! cGMP
In cases the blood volume stretches the fibers of the myocardium, the atria and ventricles, secrete _________ and _______, respectevely, which use ________ as second mesenger. cGMP
Nitric Oxide is also known as: EDRF
EDRF or NO uses cGMP
cGMP associated with NO, BNP, ANP
GOAT HAG mnemonic for hormones using IP3
GnRH, Oxytocin, ADH (V1 receptor), TRH, Histamine (H1 receptor), Angiotensin II, and Gastrin, use _________. IP3
_______ is used by ADH ___ receptor and Histamine ____ receptor. IP3; V1; H1
cAMP has the -______ receptors, and IP3 has the -_____ receptors, for ADH and Histamine. 2; 1
ATT II uses ________. IP3
Which GI hormone used the IP3 signaling pathway? Gastrin
Mnemonic used for intracellular receptors PET CAT on TV
Use intracellular receptors: Progesterone, Estrogen, Testosterone, Cortisol, Aldosterone, T3/T4, Vitamin D
Vitamin D has an _________________________ receptor Intracellular receptor
Cortisol, Estrogen and T3 use an ______________________ receptor Intracellular receptor
Sex hormone, Testosterone and Estrogen, use what type of second messenger system? Intracellular receptor
MAP kinase pathway is related to the: Receptor Tyrosine Kinase
Which hormones use the receptor tyrosine kinase? Insulin, IGF-1, FGF, PDGF, and EGF
Growth factors use which signaling pathway? Receptor Tyrosine Kinase
Insulin uses the ____________________________. Receptor Tyrosine Kinase
Glucagon uses _______________ and Insulin uses ___________________. cAMP; Receptor Tyrosine Kinase
The JAK/STAT pathway is associated with which signaling pathway? NON-receptor Tyrosine Kinase
Which hormones use the NON-receptor Tyrosine Kinase pathway? Prolactin, Immunomodulators (cytokines IL-2, IL-6, INF), GH, G-CSF, Erythropoietin, Thrombopoietin.
Cytokine that aids in activation of NK cells, uses which signaling pathway? IL-2 uses the NON-receptor Tyrosine Kinase
During pregnancy the elevated level of progesterone inhibit the release of ________________, endocrine hormone, responsible for milk letdown. Prolactin; NON-receptor Tyrosine Kinase
Patient complains of increasing hat size, and last year had to buy new wedding ring since it was to small. What is the most common Dx? any signaling pathway relation? Patient has Acromegaly, most likely by Pituitary adenoma. It produces excessive GH in adults. The GH uses the NON-receptor Tyrosine Kinase Pathway.
Created by: rakomi