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Micro Exam 3

Adaptive Immune System April 15th

DefinitionTerm
Th1 - INF-γ, IL-12​ Th2- IL-4, IL-10​ Cytokines are both in the innate and adaptive systems. They are crucial to in leukocyte development via...
leukocyte migration Chemokines stimulate what?
Bind Ig motifs and extracellular matrix​. Strengthen contact between leukocytes and other cells.​ Adhesion Molecules: INTEGRINS function to do what jobs?
Aid newly differentiated lymphocytes to migrate to lymph nodes.​ Initial binding steps lead to diapedesis (crossing blood vessel).​ Limited to their distribution in the body. Adhesion Molecules: SELECTINS and ADDRESSINS function to do what jobs?
Selectin - L-selectin ​ An example of a selectin is?
Addressin - GlyCAM-1​ An example of an addressin is?
Six (6) polypeptides associated with the TCR​. Transduces transmembrane signaling when TCR engaged.​ Signaling cascade initiates T-cell responses. Cluster of Differentiation of Molecules: CD3 roles include...
Single chain Ig supergene family.​ Expressed on 2/3 of mature T cells.​ CD4 recognize the nonpeptide binding domains of MHC II.​ Cluster of Differentiation of Molecules: CD4 roles include...
CD4 Cells expressing ___ are known as T-helper cells (Th) cells.
CD4 & CD8 Which molecules are associated with intracellular kinases and synergized with the TCR for T-cell activation?
Two chain cell surface molecule​. Homo or heterodimer (αα or αβ)​. Expressed by about 1/3 of mature T cells. CD8 is a...
CD8 recognizes and attaches at the nonpeptide binding portion of MHC I bc it is a coreceptor. CD8+ T cells only recognized pMHC I.​ CD8 recognizes what?
Known as cytotoxic T (Tc) and suppressor T (Ts) cells​. CD8 molecules are known as what?
IL-4 : the driving force of allergic responses This cytokine is important in differentiation of Th2 responses.
diapedesis, rolling motion through blood vessel, and tighter binding to other cells Selectins and Addressins play a role in?
Increase in expression During an inflammatory response, you would expect adhesion molecules such as integrins, selectins, and addressins to?
Membrane bound​. Associated with CD3 to initiate signaling.​ T-cell receptors are:
CAN NOT bind soluble eptiopes T-cell receptors CAN NOT do this.
Recognize epitopes when presented in MHC molecules (peptide-MHC, pMHC). T-cell receptors can recognize epitopes when presented in what molecules?
a variable and constant region domain. Each TCR polypeptide chain contains what 2 structural components?
Variable domains In T-cell receptors, these domains together with the complementarity-determining regions (CDRs) interact with pMHC.
Intracellular antigens. CD8+ T-cells interact with MHC-I and are ___ antigens.
Extracellular antigens. CD4+ T-cells interact with MHC-II and are ___ antigens.
MHC I or II A TCR requires this molecule to sense peptide epitopes.
Epitope T-cell receptors are ___ specific like immunoglobulins?
T-cell Heterodimers​ are αβ​ and γδ​, which are only expressed on one type of cell. Which cell is it?
1 variable and 1 constant Each polypeptide of a T-cell receptor has __ variable region and __ constant region.
Deletions, Inversions, and Junctional diversity. DNA rearrangement of TCRs include/TCR diversity: (3)
deoxynucleotidyl transferase (TdT) What enzyme does the addition and removal of nucleotides by deoxynucleotides?
14 and 7 T-cell receptor gene clusters are found on which 2 chromosomes?
Light chains α and γ. Heavy chain β and ​δ.​ T-cell diversity includes:
3 million How many αβ variable region possible recombinations are there?
600 How many γδ variable region possible recombinations are there?
random rearrangement of V(D)J genes through deletion and inversion What level of T-cell diversity is the FIRST level?
Tdt transferase which creates junctional diversity What level of T-cell diversity is the SECOND level?
Deletion of intervening mRNA joins V(D)J with C regions. C regions = constant regions During T-cell diversity, deletion does this.
Unique specificity T-cells randomly generate TCRs with this special feature.
NO isotype switching. NO somatic hypermutation. T-cells DO NOT undergo subsequent changes like immunoglobulin genes. They don't do the following:
TdT transferase This enzyme is responsible for junctional diversity.
FIRST level What level of T-cell diversity do recombination activating genes (Rag-1 or Rag-2 recombinases) occur?
TdT transferase. This enzyme(s) is important for junctional diversity by adding or subtracting nucleotides during V(D)J recombination.
Created by: 576937752774223