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Micro 3 Exam

Adaptive Immune System April 12th

B-cell Immunoglobulin rearrangements occur early in ___ precursor development.
variety BCR/Antibody Variability: Gene rearrangements and allelic exclusions allow for generation of...
B-cell Each ___ expresses only one immunoglobulin specificity.
V and J Light chains and their variable regions: We get rearrangement of ___ and ___ genes
DNA level Light chain rearrangement occurs at what level?
2 regions How many regions for gene rearrangement are there?
VDJ recombinase; random Rearrangement of light chain genes is facilitated by ___ and this happens at ___?
mRNA level Uniting variable and constant regions of light chains occurs at the what level?
Translated into a single polypeptide.​ On light chains at the mRNA level, VJ segment is spliced to constant mRNA and then whathappens?​
DNA VJ joining in the light chain occurs at what level?
V, D, and J At the heavy chains of immunoglobulins/ antibodies, the variable regions: have the rearrangement of which three genes?
first DJ is formed ___, then VDJ is formed by removal of intervening DNA.
VDJ recombinase Heavy chain variability is facilitated by? and happens at random.
permits permeability of blood vessels TNF-alpha
3 regions Heavy chain rearrangement of V, D, and J genes occurs at how many regions?
mRNA VDJ splicing to the constant regions occurs at the ___ level just like light chains. ​
random combinations Antigen binding variability is determined by ___ of light and heavy chain variable regions and millions of combos are possible.
monomeric IgM or IgD Unstimulated B-cells display what isotypes on their cell surface?
Isotype Switching Stimulation of B-cells leads to a change in isotype but not specificity. This is called...
SINGLE B -cells only produce how many isotypes at a time?
IgG and IgM Which isotypes activate the complement?
IgA Which isotypes are secreted into the mucus membrane?
IgE Which isotypes are bound to the surface of cells (mast cells and basophils)?
pyretic (fever inducer) bc it raises body temperature IL-6 is a
IgM The initial antibody response is dominated by what isotype?
reserve memory B-cell Not all B-cells are become plasma cells bc some are kept as a?
C region With the correct cytokine signals, memory B cells undergo further rearrangement with ___ region genes generating new isotype.​
human leukocyte antigen (HLA). MHC is also known as?
Major Histocompatibility Complex (MHC) MHC III are complement components of?
transplantation MHC matching is critical during?
β2​ MHC 1 molecules are co-dominantly expressed in association with?
nucleated cells​ MHC 1 molecules are found on the surface of all what cell types?
is formed between α1 and α2 that binds an 8-9 aa peptide.​​ In MHC 1 molecules, a cleft is formed between?
DCs, macrophages, and B-cells.​ MHC ll molecules are normally expressed on what cells?
HLA gene in cis and trans MHC II molecules α and β combine only from the same
is formed between α1 and β1 that binds an 18-20 aa peptide.​ In MHC II molecules, a cleft is formed between?
MHC I and are intracellular antigens CD8+ T-cells interact with ___ and are ___?
MHC II and are extracellular antigens CD4+ T-cells interact with ___ and are ___?
Created by: 576937752774223