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Exam 3 Micro
Innate and adaptive immunity pt 3
| Definition | Term |
|---|---|
| Where T-cells get trained. First lymphoid organ to develop. Sit of thymic education for T-cells. | Primary Organ: THYMUS |
| Self MHC. promotes thymocytes with receptors that interact with self MHC. eliminates those that cannot. | Thymus: Positive Selection |
| Self epitopes. Cells that cannot be selected out undergo apoptosis. Eliminates thymocytes that react against self epitopes. | Thymus: Negative Selection |
| Site of B-cell development & maturity. Self recognition of early cells leads to apoptosis. | Primary Organ: BONE MARROW |
| programmed cell death & non-inflammatory in nature | Apoptosis |
| clears blood and concentrates blood borne antigens and microbes. | Secondary Organ: SPLEEN |
| Separate for the circulatory system. They filter lymph fluid and are sites for mixing of dendritic cells, monocytes and lymphocytes (antigen presenting cells). | Secondary Organ: LYMPH NODES |
| sites other than lymph nodes where lymphocytes and antigen presenting cells mix. | Secondary Organ: MUSCOSAL-ASSOCIATED LYMPHOID TISSUE (MALT) |
| additional circulatory system outside of the cardiovascular system that carries leukocytes (WBCs), cell debris and lymph fluid | Secondary Organ: LYMPHATIC CIRCULATORY SYSTEM |
| Bone Marrow | This organ is the site of development of B-cells |
| T-cell undergoes apoptosis if they bind to self antigens | The negative selection of T-cells is in the thymus. What is the key feature of negative selection? |
| T-cells undergo apoptosis if they can't bind to MHC | What is the key feature of positive selection? |
| give rise to leukocytes(WBCs) | Cells of the innate immune system: Pluripotent hematopoietic stem cells... |
| Defense against microbes. Classified by morphology. Specialized roles in the immune response. | What are the 3 jobs of the Leukocytes (WBCs)? |
| for Phagocytosis | Cells of the innate immune system: Myeloid lineage cells - Agranular Leukocytes: Monocytes and Macrophages |
| In Circulation | Monocytes are for... |
| Tissue Resident. Professional antigen presenting cells. | Macrophages are... |
| for Phagocytosis, Macropinocytosis, Professional Antigen Presenting cells. | Myeloid lineage cells- Agranular Leukocytes: Dendritic cells |
| a sea urchin | Dendritic cells look like... |
| Most numerous leukocyte. Release granules containing antimicrobial factors. | Myeloid lineage cells - Granular Leukocytes: Neutrophils (polymorphonuclear leukocytes-PMNs) |
| Histamine, leukotrienes, proteases and pro-inflammatory cytokines. Allergic reactions. Found in circulation. | Myeloid lineage cells - Granular Leukocytes: Basophils |
| Histamine, leukotrienes, proteases, and pro-inflammatory cytokines. Allergic reactions. Found in tissues. | Myeloid lineage cells - Granular Leukocytes: Mast cells |
| Important in helminth (worms) responses. Granule contain various proteins that are proinflammatory and toxic. | Myeloid lineage cells - Granular Leukocytes: Eosinophils |
| Mast, PMNs, Eosinophils. | Granular leukocytes include |
| Macrophages. Monocytes. Dendritic cells. | Agranular leukocytes include |
| Mast cells | These granular cells are tissue specific and can release histamine and various other pro-infammatory proteins |
| innate and adaptive immune systems | Dendritic cells are the bridge between |
| B cells ( B lymphocytes): Each B cell is specific and produces only one type of antibody that recognizes only one epitope. Uses antibody as receptor. B cell receptor (BCR) | Lymphoid cells lineage: B-cells |
| differentiated B-cells. Antibody factories. | Plasma cells |
| recognize MHC ll and are T helper cells. | Lymphoid lineage: T-cells(T lymphocytes) = CD4 + T-cells |
| recognize MHC l. Cytotoxic T-cells. Kills cells infected with intracellular bacteria and viruses. | Lymphoid lineage: T-cells(T lymphocytes) = CD8 + T-cells |
| CD4 | The majority of all T-cell group types are... |
| Lack CD3, TCR and BCR. Kill virally infected cells and tumor cells.Granules contain perforin and granzyme. | Lymphoid lineage: Natural Killer Cells |
| Similar to NK cells but express TCR. | Natural Killer T Cells |
| They give rise to all leukocyes. | What is the significance of pluripotent hematopoietic stem cells? |
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