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Exam 3 Micro

Innate and adaptive immunity pt 3

Where T-cells get trained. First lymphoid organ to develop. Sit of thymic education for T-cells. Primary Organ: THYMUS
Self MHC. promotes thymocytes with receptors that interact with self MHC. eliminates those that cannot. Thymus: Positive Selection
Self epitopes. Cells that cannot be selected out undergo apoptosis. Eliminates thymocytes that react against self epitopes. Thymus: Negative Selection
Site of B-cell development & maturity. Self recognition of early cells leads to apoptosis. Primary Organ: BONE MARROW
programmed cell death & non-inflammatory in nature Apoptosis
clears blood and concentrates blood borne antigens and microbes.​ Secondary Organ: SPLEEN
Separate for the circulatory system. They filter lymph fluid and are sites for mixing of dendritic cells, monocytes and lymphocytes (antigen presenting cells).​ Secondary Organ: LYMPH NODES
sites other than lymph nodes where lymphocytes and antigen presenting cells mix. Secondary Organ: MUSCOSAL-ASSOCIATED LYMPHOID TISSUE (MALT)
additional circulatory system outside of the cardiovascular system that carries leukocytes (WBCs), cell debris and lymph fluid Secondary Organ: LYMPHATIC CIRCULATORY SYSTEM
Bone Marrow This organ is the site of development of B-cells
T-cell undergoes apoptosis if they bind to self antigens The negative selection of T-cells is in the thymus. What is the key feature of negative selection?
T-cells undergo apoptosis if they can't bind to MHC What is the key feature of positive selection?
give rise to leukocytes​(WBCs) Cells of the innate immune system​: Pluripotent hematopoietic stem cells...
Defense against microbes. Classified by morphology. Specialized roles in the immune response. What are the 3 jobs of the Leukocytes (WBCs)?
for Phagocytosis​ Cells of the innate immune system: Myeloid lineage cells - Agranular Leukocytes: Monocytes and Macrophages
In Circulation Monocytes are for...
Tissue Resident. Professional antigen presenting cells. Macrophages are...
for Phagocytosis, Macropinocytosis, Professional Antigen Presenting cells. Myeloid lineage cells- Agranular Leukocytes: Dendritic cells
a sea urchin Dendritic cells look like...
Most numerous leukocyte. Release granules containing antimicrobial factors. Myeloid lineage cells - Granular Leukocytes: Neutrophils (polymorphonuclear leukocytes-PMNs)
Histamine, leukotrienes, proteases and pro-inflammatory cytokines​. Allergic reactions​. Found in circulation. Myeloid lineage cells - Granular Leukocytes: Basophils
Histamine, leukotrienes, proteases, and pro-inflammatory cytokines​. Allergic reactions​. Found in tissues. Myeloid lineage cells - Granular Leukocytes: Mast cells
Important in helminth (worms) responses​. Granule contain various proteins that are proinflammatory and toxic. Myeloid lineage cells - Granular Leukocytes: Eosinophils
Mast, PMNs, Eosinophils. Granular leukocytes include
Macrophages. Monocytes. Dendritic cells. Agranular leukocytes include
Mast cells These granular cells are tissue specific and can release histamine and various other pro-infammatory proteins
innate and adaptive immune systems Dendritic cells are the bridge between
B cells ( B lymphocytes)​: Each B cell is specific and produces only one type of antibody that recognizes only one epitope.​ Uses antibody as receptor. B cell receptor (BCR)​ Lymphoid cells lineage: B-cells
differentiated B-cells. Antibody factories. Plasma cells
recognize MHC ll and are T helper cells. Lymphoid lineage: T-cells(T lymphocytes) = CD4 + T-cells
recognize MHC l. Cytotoxic T-cells. Kills cells infected with intracellular bacteria and viruses. Lymphoid lineage: T-cells(T lymphocytes) = CD8 + T-cells
CD4 The majority of all T-cell group types are...
Lack CD3, TCR and BCR​. Kill virally infected cells and tumor cells.​Granules contain perforin and granzyme. Lymphoid lineage: Natural Killer Cells
Similar to NK cells but express TCR. Natural Killer T Cells
They give rise to all leukocyes. What is the significance of pluripotent hematopoietic stem cells?
Created by: 576937752774223



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