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RNA Virus(sect.4.7)

HIV Antiviral Drug Classes

QuestionAnswer
Nucleoside analogs (nukes) block reverse transcriptase. makes a DNA copy of the RNA genome
Non-nucleoside analogs (non-nukes) block reverse transcriptase (in a different way)
Protease inhibitors block viral protease
Integrase inhibitors block viral intergrase, viral DNA is not inserted into chromosome; several in clinical trials, none currently FDA approved
Fusion inhibitors T-20 prevents viral entry; latest drug, injected
How many Antiretroviral drugs are approved by the FDA 19
What is the average monthly cost >1,200
They must be taken on a strict time schedule
Do they have any side effects Yes, SEVERE
Do they work for everyone? NO
What are the side effects of anitviral drugs Liver damage/failure. Diabetes. Lipodystrophy, abnormal accumulation of fat in back and abdomen, and sunken in face. High fat concentration in blood. Bone loss and heart attacks. Hallucinations, vivid dreams and rashes
What are the obstacles to vaccine development HIV constantly changes, HIV only infects humans; there is no animal model. Don't know what part of HIV to target. Don't know what an effective ammune response to HIV is and how to stimulate that.
Created by: mdnlght
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