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Adrenergic Drugs

Adrenergic Agonist AKA sympathomimetics. Stimulate the SNS and mimic the effects of SNS endogenous neurotransmitters (catecholamines) norepinephrine, epinephrine, and dopamine.
Adrenergic Receptors Receptor sites for the catecholamines norepinephrine, and epinephrine. Adrenergic drugs bind to these sites and responses are produced when the sites are either stimulated or blocked.
Alpha-Adrenergic Receptors (1 & 2) (Sub-types 1 and 2) Type 1 - postsynaptic location (located on the actual tissue, muscle, or organ). Type 2- presynaptic location. Controls the release of neurotransmitters.
Beta-Adrenergic Receptors (1 & 2) (Sub-types 1 and 2...3) Type 1- (1 HEART) located on the heart. Type 2- (TWO LUNGS) located on the smooth muscle fibers of bronchioles, arterioles, and visceral organs.
Alpha-Adrenergic Agonist Response (1 & 2) Vasoconstriction, and CNS stimulation. 1- Relaxation of GI smooth muscle, contraction of uterus/bladder, male ejaculation, pupil dilation (contraction of pupillary muscles). 2- Usually reverses sympathetic acvtivity (not a great significance).
Beta-Adrenergic Agonist Response (1 & 2) 1- ^ Renin secretion. Cardiac stimulation. ^ force of contraction, ^heart-rate, ^ AV node electrical impulse. 2- Bronchial, GI, and uterine (beta-3 detrusor) smooth muscle relaxation. Liver glycogenolysis (glycogen to glucose= ^ energy). 3- ^ Bladder Cap.
Dopaminergic Receptor + Response Stimulated only by dopamine, cause vessels of renal, mesenteric, coronary, and cerebral arteries to dilate. (^ Blood flow to these tissues).
Positive Inotropic Effect (Beta1) Increased force of contraction.
Positive Chronotropic Effect (Beta1) Increased heart rate.
Positive Dromotropic Effect (Beta1) Increased conduction of cardiac electrical nerve impulses through AV node.
Bronchodilators (Beta2) Adrenergic drugs that treat asthma/bronchitis. Usually end in -ol. Albuterol, formoterol, levalbuterol, metaproterenol, pirbuterol, salmeterol. Also Ephedrine (a/b), Epinephrine (a/b), Terbutaline (b2) (stops premature labor too).
Nasal Decongestants (Alpha1) Adrenergic drug that constricts dilated arterioles and reduce nasal blood flow which decreases congestion. Little to no Beta-receptor effect. Usually end in -ine. Ephedrine (a/b), naphazoline, oxymetazoline, tetrahydrozoline, phenylephrine.
Opthalmics (Alpha1) Adrenergics applied to the eye surface. Cause arteriolar vasoconstriction. Ephedrine (a/b), naphazoline, tetrahydrozoline, phenylephrine.
Mydriasis (Alpha/Beta2 or both) Responsible for pupil dilation and treatment of open-angle glaucoma. Reduces intraocular pressure. Epinephrine, dipivefrin.
Overactive Bladder (Beta3) Relaxes detrusor muscle during storage phase of bladder fill cycle, which leads to increased bladder storage capacity. Mirabegron.
Cardiovascular (Vasoactive Symphathomimetics) (Alpha/Beta) Vasoconstrictive/Vassopressive. Support cardiovascular system during failure or shock. Dobutamine, dopamine, ephedrine, epinephrine, midodrine, norepinephrine, phenylphrine. Fenoldopam (D1 dopamine receptor).
Ends in "-ol" Usually Beta. Relax (loose).
Ends in "-ine" Usually Alpha. (Sometimes both). Contract (tighten).
Adrenergic Contraindications Allergies/Hypertension
Created by: proulxh631