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CD Makers


what is. whose got itwhat's it do
CD2 (LFA-2); T cells, thymocytes, NK cells Adhesion molecule
CD3; T cells, thymocytes Signal transduction by the TCR
CD4; Th cells, thymocytes, monocytes, and macrophages Coreceptor for TCR-MHC II interaction, receptor for HIV
CD8; CTLs, some thymocytes Coreceptor for MHC class I–restricted T cells
CD14; Monocytes, macrophages, granulocytes Binds LPS
CD16 (Fc receptor); NK cells, macrophages, neutrophils Opsonization in Antibody Dependent Cell-Mediated Cytotoxicity (ADCC)
CD18; Leukocytes Cell adhesion molecule (missing in leukocyte adhesion deficiency)
CD19; B cells Coreceptor with CD21 for B-cell activation (signal transduction)
CD20; Most or all B cells Unknown role in B-cell activation
CD21 (CR2); Mature B cells Receptor for complement fragment C3d, forms coreceptor complex with CD19, Epstein-Barr virus receptor
CD25; Activated Th cells and TReg Alpha chain of IL-2 receptor
CD28; T cells T-cell receptor for costimulatory molecule B7
CD34; Precursors of hematopoietic cells, endothelial cells in HEV Cell–cell adhesion, binds L-selectin
CD40; B cells, macrophages, dendritic cells, endothelial cells Binds CD40L, role in T-cell–dependent B cell, macrophage, dendritic cell and endothelial cell activation
CD56; NK cells Cell adhesion
CD152 (CTLA-4); Activated T cells Negative regulation: competes with CD28 for B7 binding
Created by: JustinCo