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Ctytokines
Med3
what is. where from | where go. for what |
---|---|
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others | Th cells; Costimulates activation |
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others | B cells; Promotes maturation and clonal expansion |
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others | NK cells; Enhances activity |
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others | Endothelial cells; Increases expression of ICAMs |
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others | Macrophages and neutrophils; Chemotactically attracts |
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others | Hepatocytes; Induces synthesis of acute- phase proteins |
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others | Hypothalamus; Induces fever |
IL-2; Th cells | Antigen-primed Th and CTLs; Induces proliferation, enhances activity |
IL-3; Th cells, NK cells | Hematopoietic cells (myeloid); Supports growth and differentiation |
IL-4; Th2 cells | Antigen-primed B cells; Costimulates activation |
IL-4; Th2 cells | Activated B cells; Stimulates proliferation and differentiation, induces class switch to IgE |
IL-5; Th2 cells and mast cells | Bone marrow cells; Induces eosinophil differentiation |
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells | Proliferating B cells; Promotes terminal differentiation into plasma cells |
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells | Plasma cells; Stimulates Ab secretion |
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells | Myeloid stem cells; Helps promote differentiation |
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells | Hepatocytes; Induces synthesis of acute- phase proteins |
IL-7; Bone marrow, thymic stromal cells | Lymphoid stem cells; Induces differentiation into progenitor B and T cells |
IL-8; Macrophages, endothelial cells | Neutrophils; Chemokine, induces adherence to endothelium and extravasation into tissues |
IL-10; Th2 cells, TReg cells | Macrophages; Suppresses cytokine production by Th1 cells |
IL-11; Bone marrow stroma | Bone marrow; increase platelet count |
IL-12; Macrophages, B cells | Activated CD8+ cells; Acts synergistically with IL-2 to induce differentiation into CTLs |
IL-12; Macrophages, B cells | NK and LAK cells and activated Th1 cells; Stimulates proliferation |
IL-13; Th2 cell | B cells; Induces isotype switch to IgE |
IL-17; Th17 cells | Fibroblasts, endothelial cells, macrophages; Increases inflammation. Attracts PMNs, induces IL-6, IL-1, TGFβ, TNFα, IL-8 |
IL-18; Macrophages | IFN-g synthesis; NK cells, Th cells, IFN-g synthesis |
Interferon-α (type I); Leukocytes | Uninfected cells; Inhibits viral replication |
IL-22; Th17 | Endothelium; Stabilizes endothelial barrier, induces secretion of microbials |
Interferon-β (type I); Fibroblasts | Uninfected cells; Inhibits viral replication |
Interferon-g (type II); Th1, CTLs, NK cells | Macrophages; Enhances activity |
Interferon-g (type II); Th1, CTLs, NK cells | Many cell types; Increases expression of classes I and II MHC |
Interferon-g (type II); Th1, CTLs, NK cells | Proliferating B cells; Induces class switch to IgG2a, blocks IL-4–induced class switch to IgE and IgG1 |
Interferon-g (type II); Th1, CTLs, NK cells | Th2 cells; Inhibits proliferation |
Interferon-g (type II); Th1, CTLs, NK cells | Phagocytic cells; Mediates effects important in DTH, treatment for CGD |
Transforming growth factor-β; Platelets, macrophages, lymphocytes, mast cells | Proliferating B cells; Induces class switch to IgA |
Tumor necrosis factor-α; Macrophages, NK cells | Tumor cells; Has cytotoxic effect |
Tumor necrosis factor-α; Macrophages, NK cells | Inflammatory cells; Induces cytokine secretion, causes cachexia of chronic inflammation |
Tumor necrosis factor-β; Th1 and CTL | Tumor cells; Has cytotoxic and other effects, like TNF-α |
Tumor necrosis factor-β; Th1 and CTL | Macrophages and neutrophils; Enhances phagocytic activity |
Granulocyte colony- stimulating factor (G-CSF); Macrophages and Th cells | Bone marrow granulocyte precursors; Induce proliferation, used clinically to counteract neutropenia following ablative chemotherapy |
Granulocyte– macrophage colony-stimulating factor (GM-CSF); Macrophages and Th cells | Bone marrow granulocyte and macrophage precursors; Induces proliferation- used clinically to counteract neutropenia following ablative chemotherapy |