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Ctytokines

Med3

what is. where fromwhere go. for what
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others Th cells; Costimulates activation
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others B cells; Promotes maturation and clonal expansion
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others NK cells; Enhances activity
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others Endothelial cells; Increases expression of ICAMs
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others Macrophages and neutrophils; Chemotactically attracts
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others Hepatocytes; Induces synthesis of acute- phase proteins
Interleukin (IL)-1; Monocytes, macrophages, B cells, dendritic cells, endothelial cells, others Hypothalamus; Induces fever
IL-2; Th cells Antigen-primed Th and CTLs; Induces proliferation, enhances activity
IL-3; Th cells, NK cells Hematopoietic cells (myeloid); Supports growth and differentiation
IL-4; Th2 cells Antigen-primed B cells; Costimulates activation
IL-4; Th2 cells Activated B cells; Stimulates proliferation and differentiation, induces class switch to IgE
IL-5; Th2 cells and mast cells Bone marrow cells; Induces eosinophil differentiation
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells Proliferating B cells; Promotes terminal differentiation into plasma cells
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells Plasma cells; Stimulates Ab secretion
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells Myeloid stem cells; Helps promote differentiation
IL-6; Monocytes, macrophages, Th2 cells, bone marrow stromal cells Hepatocytes; Induces synthesis of acute- phase proteins
IL-7; Bone marrow, thymic stromal cells Lymphoid stem cells; Induces differentiation into progenitor B and T cells
IL-8; Macrophages, endothelial cells Neutrophils; Chemokine, induces adherence to endothelium and extravasation into tissues
IL-10; Th2 cells, TReg cells Macrophages; Suppresses cytokine production by Th1 cells
IL-11; Bone marrow stroma Bone marrow; 􏰀 increase platelet count
IL-12; Macrophages, B cells Activated CD8+ cells; Acts synergistically with IL-2 to induce differentiation into CTLs
IL-12; Macrophages, B cells NK and LAK cells and activated Th1 cells; Stimulates proliferation
IL-13; Th2 cell B cells; Induces isotype switch to IgE
IL-17; Th17 cells Fibroblasts, endothelial cells, macrophages; Increases inflammation. Attracts PMNs, induces IL-6, IL-1, TGFβ, TNFα, IL-8
IL-18; Macrophages IFN-g synthesis; NK cells, Th cells, IFN-g synthesis
Interferon-α (type I); Leukocytes Uninfected cells; Inhibits viral replication
IL-22; Th17 Endothelium; Stabilizes endothelial barrier, induces secretion of microbials
Interferon-β (type I); Fibroblasts Uninfected cells; Inhibits viral replication
Interferon-g (type II); Th1, CTLs, NK cells Macrophages; Enhances activity
Interferon-g (type II); Th1, CTLs, NK cells Many cell types; Increases expression of classes I and II MHC
Interferon-g (type II); Th1, CTLs, NK cells Proliferating B cells; Induces class switch to IgG2a, blocks IL-4–induced class switch to IgE and IgG1
Interferon-g (type II); Th1, CTLs, NK cells Th2 cells; Inhibits proliferation
Interferon-g (type II); Th1, CTLs, NK cells Phagocytic cells; Mediates effects important in DTH, treatment for CGD
Transforming growth factor-β; Platelets, macrophages, lymphocytes, mast cells Proliferating B cells; Induces class switch to IgA
Tumor necrosis factor-α; Macrophages, NK cells Tumor cells; Has cytotoxic effect
Tumor necrosis factor-α; Macrophages, NK cells Inflammatory cells; Induces cytokine secretion, causes cachexia of chronic inflammation
Tumor necrosis factor-β; Th1 and CTL Tumor cells; Has cytotoxic and other effects, like TNF-α
Tumor necrosis factor-β; Th1 and CTL Macrophages and neutrophils; Enhances phagocytic activity
Granulocyte colony- stimulating factor (G-CSF); Macrophages and Th cells Bone marrow granulocyte precursors; Induce proliferation, used clinically to counteract neutropenia following ablative chemotherapy
Granulocyte– macrophage colony-stimulating factor (GM-CSF); Macrophages and Th cells Bone marrow granulocyte and macrophage precursors; Induces proliferation- used clinically to counteract neutropenia following ablative chemotherapy
Created by: JustinCo
 

 



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