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Opiates, Barbs,Benzo

Pharm: CNS drugs 1

name 7 opiates morphine, fentanyl, codeine, heroin, methadone, meperidine, dextromethorphan
mechanism of action of opiates open K+ channels, close Ca2+ channels (decreased synaptic transmission)
opiate for cough suppression dextromethorphan
opiate for diarrhea loperamide, diphenoxylate
pinpoint pupils is s/e of what drugs? opiates
what 2 drugs treat opiate toxicity? naloxone, naltrexone
mechanism of butorphanol (it's in opiate class of drugs) partial agonist at mu (therefore induces withdrawal if pt is taking a regular agonist), full agonist at kappa receptors
name the opiates at these 3 receptors: mu, kappa, delta mu=morphine, kappa=dynorphin, delta=enkephalin
Tramadol (tram it all) mechanism? very weak opioid agonist, also blocks serotonin and NE reuptake (tram it all in)
thiopental is what type of drug? barbiturate; used as an anesthetic induction agent
affect of barbs on GABAa receptors? increase duration (barbiDURATE) of Cl- channel opening
which increases P450? barbs or benzo? barbiturates
benzodiazepines affect GABAa how? increase Cl- channel frequency (FREzodiazpines)
which benzos are used for status epilepticus? lorazepam and diazepam
short acting benzodiazepines? TOM thumb is short! triazolam, oxazepam, midazolam <---all have highest addiction potential
which one has less risk of resp depression/coma? benzo or barbs? benzos
how do you treat OD of benzos vs OD of barbs? benzo's actually have a drug: flumazenil (comp antagonist at GABA receptor), barb's you treat the symptoms
what do you use to treat alcohol withdrawal (delerium tremens)? benzodiazepenes
Created by: jsad