click below
click below
Normal Size Small Size show me how
Opiates, Barbs,Benzo
Pharm: CNS drugs 1
Question | Answer |
---|---|
name 7 opiates | morphine, fentanyl, codeine, heroin, methadone, meperidine, dextromethorphan |
mechanism of action of opiates | open K+ channels, close Ca2+ channels (decreased synaptic transmission) |
opiate for cough suppression | dextromethorphan |
opiate for diarrhea | loperamide, diphenoxylate |
pinpoint pupils is s/e of what drugs? | opiates |
what 2 drugs treat opiate toxicity? | naloxone, naltrexone |
mechanism of butorphanol (it's in opiate class of drugs) | partial agonist at mu (therefore induces withdrawal if pt is taking a regular agonist), full agonist at kappa receptors |
name the opiates at these 3 receptors: mu, kappa, delta | mu=morphine, kappa=dynorphin, delta=enkephalin |
Tramadol (tram it all) mechanism? | very weak opioid agonist, also blocks serotonin and NE reuptake (tram it all in) |
thiopental is what type of drug? | barbiturate; used as an anesthetic induction agent |
affect of barbs on GABAa receptors? | increase duration (barbiDURATE) of Cl- channel opening |
which increases P450? barbs or benzo? | barbiturates |
benzodiazepines affect GABAa how? | increase Cl- channel frequency (FREzodiazpines) |
which benzos are used for status epilepticus? | lorazepam and diazepam |
short acting benzodiazepines? | TOM thumb is short! triazolam, oxazepam, midazolam <---all have highest addiction potential |
which one has less risk of resp depression/coma? benzo or barbs? | benzos |
how do you treat OD of benzos vs OD of barbs? | benzo's actually have a drug: flumazenil (comp antagonist at GABA receptor), barb's you treat the symptoms |
what do you use to treat alcohol withdrawal (delerium tremens)? | benzodiazepenes |