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DNA Viruses (sect.1)

Small Pox Virus

QuestionAnswer
Small pox History Samll Pox was world wide in scope, 15 M people infected annually, 2 M died with millions more left disfigured and sometimes blind, 1796-Jenner used cowpox to vac., 1977-Last natural case occured in Samalia, 1980-Smallpox declared eradicated
Small pox Characteristics Largest and most complex virus known, Complex brick-shaped virion, trans. does not occur until onset of rash, by then most are in bed with high fever and malaise, Mortality rate 20-30%, Often fatel disease that results from infection with the variola viru
Small pox Diagnosis Mostly confused with Chicken pox, All Small pox lesions should be at the same stage of development, Chicken pox lesions at different stages-new lesions appear in crops every few days.
Small pox Vaccine Routine vac. in the Us stopped in 1972, Bifurcated(dbl-pronged) needle used to scratch in live virions, Durration of imm. unknown, Assume us pop. is highly susceptible, Encephalitis complication occurs 1 in 30K children and 1 in 200K in adults,
Vac. Cont. Vaccine is helpful postexposure within 4 days, Complications can be severe, but if a person has definitely been in contact with small pox risk is negligible
Small pox Primary Vaccination site reaction In a successful take, a large, scablike develops at the infection site, where it leaves a permanent scar approx. 1 cm
Small pox as a biological weapon Small pox is stable in aerosol form, Stable on surfaces-24 hrs if not exposed to UV lilght, Stable on linens, cloths for extended periods, spreads from person to person by; aerosol expelled from the respiratory system, direct contact
Small pox as a biological weapon ( cont) Fomites: contaminated clothing, ** no known animal or insect resovoir
Created by: mdnlght
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