Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
hemo 10-25
16,17,18,19,Mergey
| Question | Answer |
|---|---|
| AML,MO | ACUTE MYELOGENOUS WITHOUT MATURATION, UNDIFFERENTIATED BLASTS |
| AML,M1 | ACUTE, MYELOGENOUS WITH MINIMAL MATURATION,PRODOMINANCE OF MYELOBLASTS,AUER ACUTE MYELOGENOUS WITH MINIMAL MATURATION,PROMINANCE OF MYEOBLASTS,WITH MINIMAL MATURATION. AUER RODS,SOME PROMYELOCYTES AND PSEUDO |
| AML,M2 | ACUTE MYELOGENOUS WITH MATURATION,MYEOBLASTS PREDOMINATE.SOME NMATURE BEYOND PROMYELOCYTE. AUER RODS MOST COMMON TYPE OF AML, MYEOBLAST PROMINANT |
| AML,M3 | ACUTEN PROMYELOCYTE IS PREDOMINANT CELL. MYELOBLASTS AND MYELOCYTES PRESENT.AUER RODS &DIC. UNCOMMON |
| AML,M4 | ACUTE MYELOMONOCYTIC,EARLY MYELOGENOUS CELLS AND 20% MONOCYTIC. BLASTS HAVE INDENTED AND CONVULUTED NUCLEI.AUER RODS % PSEUDO PELGER HUET.SECOND MOST COMMON GRANULOCYTES. ADULTS OVER 50 |
| AML,M5 | ACUTE MONOCYTIC, A TYPE : PREDOMINATELY MONOBLASTS. b types: PROMONOCYTES AND MONOCYTES. UNCOMMON |
| EL,M6 | ACUTE ERYTHOLEUKEMIA, ERYTHROBLASTS WITH MEGALOBLASTOID CHANGES & OTHER DYSPLASTIC FEATURES,MYEOBLASTS AND PROMYELOCYTES. AUER RODS ARE PRESENT. GRANULOCYTES,MONOCYTES |
| MegL,M7 | ACUTE MEGAKARYOBLASTIC, PROLIFERATION OF MEGAKARYOBLASTS AND ATYPICAL MEGAKARYOCYTES.MEGAKARYOCYTES FRAGMENTS MAY BE SEEN IN PERIPHERAL BLOOD. UNCOMMON |
| L1 | SMALL CELL HOMOGENOUS,SMALL LYMPHOBLASTS WITH SCANTY CYTOPLASM. ROUND NUCLEI WITH OCCASIONAL CLEFTING,HOMOGENOUS CHROMATIN, INCONSPICUOUS NUCLEOLI, MOST COMMON IN CHILDREN |
| L2 | LARGE CELL HETEROGENOUS, HETROGENOUS LARGE LYMPHOBLASTS WITH NUCLEAR CLEFTING AND INDENTATION. FOUND IN OLDER CHILREN AND ADULTS |
| L3 | BURKITT TYPE,L3N SECONDARY TO BURKITT. UNIFORM POPULATION OF LARGE LYMPHOBLASTS WITH DEEPLY,BAOSOPHILIC CYTOPLASM,VACUOLES, AND ROUND TO OVAL NUCLEI WITHOUT INDENTATIONS. |
| T lymphocytes | SURVIVE MONTHS TO YEARS |
| B-LYMPHOCYTES | SURVIVE A FEW DAYS |
| Lymphopoiesis | BONE MARROW AND THYMUS |
| SECONDARY TISSUE | Lymphs, spleen and Peyer’s patch in the intestine |
| LYMPHOCYTE RECIRCULATION | Lymphs move between the blood and lymphoid tissue |
| SUBGROUPS OF LYMPHOCYTES | T CELLS,B CELLS |
| LYMPHOCYTES ARE PRODUCED IN THE | Lymphopoiesis: Bone Marrow and ThymusSecondary Tissue: Lymphs, spleen and Peyer’s patch in the intestine |
| LYMPHOBLASTS | Size: 15-20microns N:C: 4:1 Shape: round or ovalNucleoli: 1-2 Chromatin: delicateCytoplasm: medium blue, dark rim, no granules |
| PROLYMPHOCYTE | Size: 15-18microns N:C: 4or3:1 Shape: oval & may be indentedNucleoli: 0-1 Chromatin: Sl. condensedCytoplasm: medium blue with thin dark rim |
| MATURE LYMPHOCYTE | Size: 6-9 17-20 N:C: 2:1 Shape: round/ovalNucleoli: 0 Chromatin: dense/clumpedCytoplasm: may have granules |
| VARIANT OR REACTIVE LYMPHOCYTE | ATYPICAL LYMPHOCYTES. DOWNEY CELLS,REACTIVE OR TRANSFORMED LYMPHOCYTES,LYMPHOCYTOID OR PLASMACYTOID LYMPHOCYTES AND VIROCYTES.THESE CELLS MAY BE FOUND IN INFEC MONO, VIRAL PONEUMONIA, AND VIRAL HEPITITIS. |
| CHARACTERISTICS OF VARIANT LYMPHOCYTES | Increased sizeNucleus enlargedLobulated, clefts, notches, foldsFine to granular chromatin1-3 nucleoliFoamy or vacuolated cytoplasmGray to light blue to dark cytoplasm colorGranules present |
| CYTOKINE | CHEMICAL MESSANGER/MIF migration inhibition factorMigration in delayed type hypersensitivity reactionIL-2 T cell growth factorStimulates T cell proliferationChemotactic FactorAttracts granulocytes to the affected areasIL-1 Activates T cel |
| WHAT CELL IN THE LYMPHOCYTIC SERIES RELEASES ANTIBODIES | B CELL |
| WHAT IS WHOOPING COUGH | B. PERTUSIS: INFLAMMATION OF THE ENTIRE REPIRATORY TRACT(COLD AND COUGH WITH NECK AND BACK PAIN) TOTAL WBC COUNT INCREASED AND SMALL MATURE LYMPHS-CHARACTERISTIC COUGH |
| DESCRIBE HIV | HIV/AIDS- LASTS MAY MONTHS TO YEARS- S&S- MILD CHRONIC LYMPHADENOPATHY-FLU LIKE SYMPTOMS, NEUROLOGICAL COMPLAINTS/EXTREME WEIGHT LOSS-MALIGNANT KAPOSI SARCOMA- HERPES VIRUSES-PNEUMOCYSTIS-CRYPTOSPORIDIA,H. capsulatum |
| CHARACTERISTICS OF SLE | CLASSIC MODEL OF AN AUTOIMMUNE DISORDER- INVOLVES JOINTS,CONNECTIVE TISSUE,COLLAGEN VASCULAR TISSUE DISORDERS |
| SIGNS AND SYMPTOMS OF SLE | WEIGHT LOSS-FEVER-MALAISE-ARTHRALGIA AND ERYTHEATOSUS-EVENTUALLY KIDNEY INVOLVEMENT |
| LAB TESTS FOR SLE | ANTIBODIES-LE PREP, ANA |
| INFECTIOUS MONONUCLEOSIS | SIGNS AND SYMPTOMS-USUALLY ASYMPTOMATIC-EXTREME FATIGUE- SORE THROAT-FEVER-CHILLS-MALAISE-CERVICAL LYMPHADENOPATHY |
| HOW IS INFEC MONO DIAGNOSED | ANTIBODY OR AGGLUTINATION(horse erythrocytes) |
| LAB CHARACTERISTICS OF INFEC MONO | MONONUCLEAR CELLS; TYPICAL RELATIVE LYMPHOCYTOSIS FROM 60-90% VARIANT 5-30%- ANTI- i CLINICALLY SIGNIFICANT ANTIBODY ASSOCIATTED WITH INFEC MONO |
| CMV IS | MEMBER OF THE HERPES VIRUS FAMILY-TRANSMITTED ORAL, RESPIRATORY, AND VENEREAL ROUTES- ORGAN AND BLOOD TRANSPLANTS(IN UTERO) |
| CMV IS FATAL TO | CHILDREN AND IMMUNOCOMPRIMISED PTS-ADULTS ARE ASYMPTOMATIC |
| CMV CAN BE DIAGNOSED BY | URINE OR BLOOD:CHARACTERISTIC LEUKOCYTOSIS/SL. LYMPHOCYTOSIS AND ABNORMAL LIVER FUNCTION |
| SIGNS AND SYMPTOMS OF CMV | SORE THROAT-FEVER CHILLS-PROFOUND MALAISE-MYALGIA |
| TOXOPLASMOSIS gondii TISSUE COCCIDIA | HUMAN INFECTIONS ARE COMMON AROUND THE WORLD. DEFINITIE HOST-HOUSE CAT/TRANSFUSIOB ASSOCIATED TRANSMISSION: LEUKOCYTE CONCENTRATES/AT RISK- IMMUNOCOMPRIMISED AND CORTICOSTEROID USERS. IN UTERO TRANS= PROBLEMS. |
| IF LEFT UNTREATED IN NEWBORNS T. GONDII | CAN CAUSE- CHORIORENTINITIS-UNILATERAL BLINDNESS AND NEURO PROBLEMS |
| SYMPTOMS OF T. gondii | ASYMPTOMATIC OR CAN MIMIC INFEC MONO |
| WHAT IS THE LAB DATA FOR T gondii | SEROLOGIC DIAGNOSIS OF ELEVATED ANTIBODIES,INCREASE VARIANT LYMPHS, IT IS DIFFICULT TO CULTURE |
| INFECTIOUS MONO IS CAUSED BY | EBV AND BURKITT'S LYMPHOMA TUMOR OF THE LYMPHOID TISSUE |
| HOW IS INFEC MONO TRANSMITTED | BY CLOSE OROPHARYNGEAL SECREATIONS |
| WHEN DOES A PERSON BECOME IMMUNE TO INFEC MONO | AFTER PRIMARY EXPOSURE-90% OF ADULTS DEMONSTRATE ANTIBODIES |
| INFECTIOUS MONO IS USUALLY A MINOR ILLNESS EXCEPT FOR | IMMUNOCOMPRIMISED PTS |
| GENERAL CHARACTERISTICS OF LEUKEMIA | ANEMIA-BLEEDING, INFILTRATIOIBN BY CELLULAR ELEMENTS. TOTAL WBC COUNT- INCREASED AND DECREASED. THROMBOCYTOPENIA.70 % OF ADULT PTS DIE FROM INFECTION-DEATH OCCURS WITHIN 3MNTHS IF UNTREATED.REMISSION-90%CHILDREN, 70%ADULTS.BEST-HANCE-AGGR. TRTMNT 1ST DIAG |
| CATAGORIES OF LEUKEMIA | ACUTE NONLYMPHOBLASTIC (MYELOGENOUS)LEUKEMIAS ANLL. ACUTE LYPHOBLASTIC LEUKEMIAS-ALL |
| WHAT IS THE FAB CLASSIFICATION BASED ON | MORPHOLOGICAL CHARACTERISTICS,PERIPHERAL BLOOD SMEAR,CYTOCHEMICAL STAINING, MOLECULAR ANALYSIS AND FLOW CYTOMETRY |
| GENERAL CHARACTERISTICS OF MYELOID NEOPLASMS | NEOPLASTIC DISEASES IN WHICH A CLONAL ABNORMAL STEM CELL OVERTAKES NORMAL MARROW ELEMENTS AND FILLS THE MARROW WITH ABNORMAL HEMATOPIOESIS-MAY BE EFFECTIVE,INEFFECTIVE-BLASTIC |
| ACUTE NONLYMPHOBLASTIC LEUKEMIAS | AML-MO-NOT OTHERWISE CLASSIFIED IN OTHER GROUPS.INCREASE IN THE # OF CELLS IN THE BM AND ARREST IN MATURATION.UNDIFFERENTIATED BLASTS. |
| AML-M1 | ACUTE MYELOBLASTIC LEUKEMIA W/O MATURATION-SYMPTOMS RESEMBLE INFECTION-ANEMIA AND THROMBOCYTOPENIA. PREDOMINANCE OF MYEOBLASTS. |
| LEUKMIA VERSES LYMPHOMA | MYELOGENOUS OR LYMPHATIC CELLS. LYMPHOMA-LYMPHOCYTES ONLY-LYMPH NODES OR BONE TISSUE. |
| CLASSIFICATION OF LEUKEMIAS | 1. ACUTE OR CHRONIC MYELOGENOUS 2. ACUTE OR CHRONIC MONOCYTIC 3.ACUTE OR CHRONIC MYELOCYTIC 4.ACUTE OR CHRONIC LYMPHOCYTIC.EOSINOPHILIC,BASOPHILIC,STEM CELL |
| TREATMENT OPTIONS FOR LEUKEMIA | RADIATION-ADRENOGLUCOCORTICOSTEROIDS-ANTIFOLATE-OTHER DRUGS |
| FACTORS OR CAUSES OF LEUKEMIAS | ONCOGENES-ENVIRONMENTAL EXPOSURE-CHEMICAL AND DRUG EXP-INFECTIOUS AGENTS |
| ONCOGENE | SINGLE MUTATION,DAMAGE TO DNA OF CRITICAL GENE IN CELL-ALTERED VERSIONS OF NORMAL CELLS |
| PROTO-ONCOGENES | REGULATE GROWTH IN NORMAL CELLS-PRECURSER OF ONCO GENES |
| MOST COMMON TYPE OF LEUKEMIA IN CHILDREN | ACUTE LYMPHOBLASTIC LEUKEMIA-ALL |
| LYMPHOMA | TUMOR OF THE LYMPHNODES |
| LIFE THREATENING COMPLICATIONS OF CHEMO | INFECTION, BLEEDING, LEUKEMIC INFILTRATION OF ORGANS,METABOLIC ABNORMALITIES,HYPERLEUKOCYTOSIS |
| ACUTE MYELOGENOUS LEUKEMIA FAB-1 | ALTHOUGH A TRANSLOCATION HAS BEEN OBSERVED IN AML(FAB-1)IT IS NOT A SPECIFIC MARKER.ERYTHROBLASTIC LEUKEMIA(FAB-6)A SPECIFIC MARKER HAS NOT BEEN IDENTIFIED |
| ACUTE MYELOGENOUS LEUKEMIA FAB-2 | APPROX. 10% OF PATIENTS WITH FAB M2 HAVE TRANSLOCATION BTWEEN THE LONG ARMS OF CHROMOSOMES 8&21-ASSOCIATED WITH GOOD RESPONSE TO THERAPY AND IMPROVED SURV. . TRANSLOCATION THAT IS COUPLED WITH 1 SEX CHROMOSOME,PROGNOSIS POOR |
| THEB 8;21 ABNORMALITY IS THE MOST FREQUENTLY CHROMOSOMAL ALTERATION FOUND IN | CHILDREN WITH AML FAB-2 |
| ACUTE PROMYELOCYTE LEUKEMIA FAB-M3 | IN 40% OF PTS WITH APL FAB M3 A RECIPROCAL TRANSLOCATION OF 15&17 HAVE BEEN OBSERVED IN BM CELLS.ONLY SEEN IN PTS WHO HAVE FAB M3. |
| ACUTE MYELOMONOCYTIC LEUKEMIA M4 | ALTERATION OF CHROMOSOME 16 HAS BEEN DETECTED IN PTS SUFFERING FROM ACUTE MYELOMONCYTIC LEUKEMIA.MAY BE A DELETION TYPE OF DEFECT. |
| ACUTE MONOBLASTIC LEUKEMIA M5 | TRANSLOCATION OR DELETIONS OF THE LONG ARM OF CHROMOSOME 11 COMMON.REARRANGEMENT OF LONG ARMS OF CHROMOSOME 11 IS FREQ. ASSOC. WITH CHROMOSOME 9 OR 19. NO SPECIFIC MARKERS HAVE BEEN IDENTIFIED |
| ACUTE LYMPHOBLASTIC LEUKEMIAS ARE | 90% OF LEUKEMIAS FOUND IN CHILDREN |
| SIGNS AND SYMPTOMS OF ALL | FATIGUE,FEVER, INFEC,HEADACHE, NAUSEA, VOMITTING,BONE&JOINT PAIN, TISSUE INFILTRATION |
| SIGNS AND SYMPTOMS OF ACUTE LYMPHOBLASTIC LEUKEMIA | LEUKOCYTE COUNT ELEVATED- MOSTLY BLASTS AS WELL AS LYMPHOCYTES AND SMUDGE CELLS-CURE RATE HAS GREATELY IMPROVED |
| METHODS OF CELLULAR IDENTIFICATION | SUDAN BLACK B-MYELOPEROXIDASE-PERIODIC ACID SCHIFF (PAS)- NAPHTHOL AS-D CHLOROACTE (NASDCA)ESTERASE,LAP,ACID PHOSPHOTASE WITH OR W/O TARTARIC ACID INHIB. |
| SUDAN BLACK B STAIN | DETECT CELLULAR LIPIDS NOT IDENTIFIED BY WRIGHT STAIN- LIPIDS ABSORB THE PIGMENT-POSITIVE-GRANULOCYTIC LEUKEMIA-STAINING BETTER WITH MORE MATURE NEUTROPHILS-MONO VARIABLE-LTMPH-NEG/DIFF-ALL FR- AML |
| MYELOPEROXIDASE STAIN | IS FOUND IN THE GRANULES OF MYELOID AND MONOCYTOID CELLS-POSITIVE REACTION PRODUCE BLACK PRECIPITATE-POS FOR MYELOID AND MONOCYTOID-PARALELLS SUDAN BLACK B REACTIONS-DIFF- AML AND ACUTE MONCYTIC FROM ALL |
| PERIODIC ACID SCHIFF (PAS) | POS-GLYCOGEN AND GLYCOL CONTAINING CARB.(STAINS MAGENTA PURPLE)2 STEPS-1. OXIDATION(PERIOEDIC ACID)2.SCHIFF STAIN. POS-NEUTROPHILIC GRAN-MEGAKARYOCYTES/BLASTS,ERYTHROCYTES IN ERYTHROLEUKEMIA M6. FOUND IN NEUTROPHILS(HIGH ENERGY USE) |
| ESTERASE STAIN | DIFF NEUTROPHILIC GRANULOCYTES AND MONOCYTIC CELL LINES-NASDCA POS IN GRANULOCYTIC LINEAGE-PROMONOS AND MATURE MONOS MAY BE POS-MONOBLAST-NEG/WEAKLY POS OR NEG FOR GRANULOCYTES/POS FOR ALL OTHER CELLS |
| PHOSPHATE STAINS | ALKALINE PHOSPHATE/BLUE OR VIOLET ST REFLECT THE SITES OF GRANULOCYTIC ALK. PHOS ACT. DIFF CML FROM LEUKEMOID REAC-BACT INFECT-PREG |
| PHOSPHATE STAINS 2 | ACID PHOSPHOTASE- MAROON PRECIPITATE AT CELLULAR SITES OF ACID PHOS. ACT./MONOS STAIN MORE INTENSE THAN NEUTROPHILS/DIFF ALL/T CELLS STAIN INTENSE/B CELLS POS OR NEG |
| CYTOCHEMICAL STAIN DISTINGUISH CHEMICAL COMPOSITION OF CELLS | THROUGH THE USE OF COLOR REACTION |
| ACUTE LYMPHOBLASTIC LEUKEMIAN IS CHARACTERIZED BY | by a proL. of immaT. lymphoid cells,lymphoblasts,which doN'T mat into normal lymphS. Mat. lymph help the body fight infec.Instead, the body manuf. large #'S of lymphoblasts that crowd out healthy white and RBC'S and plTS, making the body less able to fig |
| SUBTYPE MO CCONSISTS OF | UNDIFF MYELOID BLASTS |
| UNIQUE CHARACTERICS OF M1-M4 | THE POSSESION OF GRANULOCYTIC DIFFERENTIATION WITH VARYING DEGREES OF MATURATION |
| M4 REPRESENTS | A COMBINATION OF MYELOGENOUS AND MONOCYTIC LEUKEMIAS |
| M5 IS DESIGNATED CATAGORIES FOR | MONOCYTIC LEUKEMIAS WITH ADDITIONAL SUBCATAGORIES |
| M6 CATAGORY IS RESERVED FOR | ERYTHROLEUKEMIAS AN ABNORMALITY OF BOTH ERYTHROCYTIC AND MYELOGENOUS CELL LINES |
| M7 IS THE DESIGNATION FOR | MEGAKARYOCYTIC LEUKEMIAS |
| NMONOCLONAL ANTIBODIES ARE HELPFU; IN | CLASSIFICATIONS OF ACUTE LEUKEMIAS |
Created by:
wannabeaclt
Popular Biology sets