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Lukemia/lymphoma (CLL/SLL) Chronic lymphocytic leukemia/small lymphocitic lymphoma
Lymphoma Cause of Death End-organ failure, critical structure obstruction, tumor complications
WHO Classification of lymphoid malignancies (prevalence) Non-Hodgkin's (B-cell,70%; T-cell/NK-cell, 20%) Hodgkin's (10-20%)
Blood Smear for Non-Hodgkin's (general, indolent vs. aggressive) Homogeneous tumor cell population, small mature (indolent). Large and immature, various states of mitosis (aggressive)
Blood Smear for Hodgkin's Heterogeneous cell population, majority benign cells, lymphoma cells are bi nucleated (Reed-Sternberg Cells), background cells are benign,
Age distribution Hodgkin's vs. Non-Hodgkin's Hogdkin's is bimodal (25 vs. >50). Non-Hodgkin's (>50)
Lymphoma staging 1. Single side of diaphragm. 2. Multipule one side of diaphragm. 3. Both sides of diaphragm. 4. Dissiminated. For B add fever (37.5) weight loss (10%), night sweat.
Diagnosis tools for Hodgkin's Morphology, immunophenotyping, genetic tensing, clinical data, immunohistochemistry, cytogenetics
Follicle; including zones. Marginal, mantel, germinal (dark, light, apical light)
B-cell maturation process Lymphoblasts, virgin B-cell (prefollicular). Centroblasts -> centrocytes -> secondary B blasts (Follicular) Plasma cells or memory B cells (Postfollicular).
Neoplasms of precursor, pre-GC, GC, post-GC Precursor: ALL Pre-GC: CLL/SLL, Mantle cell GC: Follicular, Burkitt, DLBCL, Hodgkin's Post GC: Marginal & MALT, lymphoplasmacytic (LPL), some CLL/SLL, some DLBCL, plasma cell myeloma
Indolent vs. aggressive Indolent: Small cell lymphocytic, follicular, marginal zone, mucosa associated lymphoid tissue, splenic, nodal Aggressive: Diffuse large cell, mantle cell
CLL/SLL (age, distribution, T or B, blood smear, indolent vs. aggressive) Older adults >50years (65% of all lymphoma, up to 10% of general population, 90% of cLPD). B-cell (common), T-cell uncommon, small mature B lymphocytes (clonal), present as leukemia or lymphoma, indolent.
CLL/SLL clinical course (platelet/neutrophil/RBC, organ involvement, immunoglobulin suppression vs proliferation vs. clonal, transformation to...) anemia, neutropinea, thrombocytopnia, spleen/lymph enlargement, immunoglobulin suppression, autoimmune hemolytic anemia, transform to prolymphocytic leukemia (PLL; similar to ALL) or high grade lymphoma (richter's transformation)
Created by: otterstetter