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Hemotology
Lymphomas
| Term | Definition |
|---|---|
| Lukemia/lymphoma (CLL/SLL) | Chronic lymphocytic leukemia/small lymphocitic lymphoma |
| Lymphoma Cause of Death | End-organ failure, critical structure obstruction, tumor complications |
| WHO Classification of lymphoid malignancies (prevalence) | Non-Hodgkin's (B-cell,70%; T-cell/NK-cell, 20%) Hodgkin's (10-20%) |
| Blood Smear for Non-Hodgkin's (general, indolent vs. aggressive) | Homogeneous tumor cell population, small mature (indolent). Large and immature, various states of mitosis (aggressive) |
| Blood Smear for Hodgkin's | Heterogeneous cell population, majority benign cells, lymphoma cells are bi nucleated (Reed-Sternberg Cells), background cells are benign, |
| Age distribution Hodgkin's vs. Non-Hodgkin's | Hogdkin's is bimodal (25 vs. >50). Non-Hodgkin's (>50) |
| Lymphoma staging | 1. Single side of diaphragm. 2. Multipule one side of diaphragm. 3. Both sides of diaphragm. 4. Dissiminated. For B add fever (37.5) weight loss (10%), night sweat. |
| Diagnosis tools for Hodgkin's | Morphology, immunophenotyping, genetic tensing, clinical data, immunohistochemistry, cytogenetics |
| Follicle; including zones. | Marginal, mantel, germinal (dark, light, apical light) |
| B-cell maturation process | Lymphoblasts, virgin B-cell (prefollicular). Centroblasts -> centrocytes -> secondary B blasts (Follicular) Plasma cells or memory B cells (Postfollicular). |
| Neoplasms of precursor, pre-GC, GC, post-GC | Precursor: ALL Pre-GC: CLL/SLL, Mantle cell GC: Follicular, Burkitt, DLBCL, Hodgkin's Post GC: Marginal & MALT, lymphoplasmacytic (LPL), some CLL/SLL, some DLBCL, plasma cell myeloma |
| Indolent vs. aggressive | Indolent: Small cell lymphocytic, follicular, marginal zone, mucosa associated lymphoid tissue, splenic, nodal Aggressive: Diffuse large cell, mantle cell |
| CLL/SLL (age, distribution, T or B, blood smear, indolent vs. aggressive) | Older adults >50years (65% of all lymphoma, up to 10% of general population, 90% of cLPD). B-cell (common), T-cell uncommon, small mature B lymphocytes (clonal), present as leukemia or lymphoma, indolent. |
| CLL/SLL clinical course (platelet/neutrophil/RBC, organ involvement, immunoglobulin suppression vs proliferation vs. clonal, transformation to...) | anemia, neutropinea, thrombocytopnia, spleen/lymph enlargement, immunoglobulin suppression, autoimmune hemolytic anemia, transform to prolymphocytic leukemia (PLL; similar to ALL) or high grade lymphoma (richter's transformation) |
Created by:
otterstetter