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Rush Nursing Pharm1

Pharm test #1 flashcards

What happens in response to alpha1 activation? Vasoconstriction of blood vessels, and mydriasis. (dilation of pupil).
Where are alpha2 receptors? Alpha2 receptors are on the presynaptic terminal of neurons that secrete NE.
What happens in response to alpha2 activation? Inhibits NE release. Little therapeutic significance.
Where are beta1 receptors? Heart, kidney.
What happens in response to beta1 activation? Increased rate, contraction, renin release in kidney
Where are beta2 receptors? Bronchi, arterioles, uterus, liver, skeletal muscle.
What is the response to beta2 activation? Bronchi dilate, liver increases glycogenolysis, skeletal muscle contracts, uterus relaxes, arterioles dilate.
What happens to ACh? It is destroyed by acetylcholinesterase, which lives on the surface of the postjunctional cell.
What are the 2 substances that ACh-ase breaks ACh into? Choline and acetate.Choline is taken back up for reuse.
What happens to NE? It is taken back up by presynaptic neuron.
Where are alpha1 receptors? Eyes, blood vessels, bladder, prostatic capsule.
What would a cholinesterase inhibitor do? Keep ACh from breaking down.
What are some cholinesterase inhibitors? Insectisides such as organophosphates.
What would be symptoms of organophosphate poisoning? Bronchoconstriction, profuse salivary and gastric secretions, laryngospasm.
Created by: rushstudent