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Lecture 8: Comp Phys
Comparative Physiology USD Fall 2018 Dr. Kenneth Renner
| Question | Answer |
|---|---|
| What is anterograde transport? | transport from the cell body to the terminal |
| What are examples of things that undergo anterograde transport? | NT, vescicles, enzymes |
| What is retrograde transport? | transport from the terminal to the cell body |
| What are examples of things that undergo retrograde transport? | recycled componented to be reused |
| Presynaptic terminal has a ________ _________. | excitable membrane |
| What happens at the excitable membrane of the presynaptic terminal? | an AP opens VgCa channels open, Ca2+ enters and vescicles are present filled with NT |
| What does Ca2+ initiate after it enters the presynaptic terminal? | it initiates a series of membrane events which results in vescicle docking with presynaptic membrane |
| What happens after vescicle docking at the presynpatic membrane? | exocytosis of vescicular content (NT) into the synaptic cleft |
| What are the possible fates of NT during synapse? | 1. they can bind to postsynaptic receptor 2. they can be taken up & degrated by glial cells 3. taken back into presynaptic terminal & recycled 4. bind to presynaptic reeptor to regulate further release 5.they can diffuse away |
| What is the function of glial cells at the synapse? | NT uptake, degredation, and ion balance |
| What are the two types of anterograde transport? | Fast type and slow type |
| Fast type anterograde transport is ____ dependent. | ATP |
| What is the rate of faste type anterograde transport? | ~400 mm/day |
| What is the speed of slow type anterograde transport? | flows at the rate of axoplasmic flow |
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