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Lecture 8: Comp Phys

Comparative Physiology USD Fall 2018 Dr. Kenneth Renner

What is anterograde transport? transport from the cell body to the terminal
What are examples of things that undergo anterograde transport? NT, vescicles, enzymes
What is retrograde transport? transport from the terminal to the cell body
What are examples of things that undergo retrograde transport? recycled componented to be reused
Presynaptic terminal has a ________ _________. excitable membrane
What happens at the excitable membrane of the presynaptic terminal? an AP opens VgCa channels open, Ca2+ enters and vescicles are present filled with NT
What does Ca2+ initiate after it enters the presynaptic terminal? it initiates a series of membrane events which results in vescicle docking with presynaptic membrane
What happens after vescicle docking at the presynpatic membrane? exocytosis of vescicular content (NT) into the synaptic cleft
What are the possible fates of NT during synapse? 1. they can bind to postsynaptic receptor 2. they can be taken up & degrated by glial cells 3. taken back into presynaptic terminal & recycled 4. bind to presynaptic reeptor to regulate further release 5.they can diffuse away
What is the function of glial cells at the synapse? NT uptake, degredation, and ion balance
What are the two types of anterograde transport? Fast type and slow type
Fast type anterograde transport is ____ dependent. ATP
What is the rate of faste type anterograde transport? ~400 mm/day
What is the speed of slow type anterograde transport? flows at the rate of axoplasmic flow
Created by: kenzigustafson
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