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Lecture 5: Comp Phys

Comparative Physiology USD Fall 2018 Dr. Kenneth Renner

Transport that doesn't require energy passive transport
What does passive transport require? eithera concentration gradient and/or an electrical gradient across the cell as a driving force
What are the three routes of passive transport? diffusion of lipid soluble substances, carrier mediated transport, and diffusion through aqueous channels
What is diffusion of lipid soluble substances? passive transport where substances dissolve in the lipid bilayer
What does diffusion of lipid soluble substances depend on? number of hydrogen bonds broken from H2O and substance solubility
What does the graph of diffusion of lipid soluble substances look like? positive linear graph
What is diffusion through aqueous channels? ions passing through a channel/ pore and they bounce on the channel walls transporting across a resistance
What does the graph of diffusion through aqueous channels look like? the graph has a positive linear slope until a certain point then the slope decreases
Why does the slope of the graph for diffusion through aqueous channels decrease? because the channels have more resistance when the extracellular concentration gets high enough
What is carrier-mediated transport? carriers used to transport substances
What does the graph of carrier-mediated transport? positive, linear slope until a certain point it stops increasing
Why does the carrier-mediated transport graph taper off? all carriers become saturated when in high concentrations of substances being transported
What are the 4 criteria for carrier-mediated transport? 1.tranport is saturable 2. transport is selective 3. inhibited by competitive inhibition 4.no direct expenditure of energy
What are 3 forms of passive carrier-mediated transport? uniport, symport, antiport
Explain uniport passve carrier-mediated transport? transport of a molecule from one side of the membrane to the other
How does the glucose uniport system work? active site binds glucose which induces a confirmation bringing glucose inside
Explain the symport system? uses the electrical and/or chemical gradient to drive transport of another substance in the same direction
Explain amino acid transport sodium is the driving force because of its electrical and chemical gradient. amino acid is being transported against its gradient. Na and a.a. are bound at the same time and the driving force for Na+ overcomes the counteracting a.a. and both transport
Created by: kenzigustafson